Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

Govoni, Verônica Mollica; Pigoli, C.; Sueiro, Felipe Augusto Ruiz; Zuliani, F; Silva, Thayná O da; Quitzan, Juliany Gomes; Laufer-Amorim, Renée; Grieco, Valeria; Fonseca‐Alves, Carlos Eduardo

doi:10.5455/ovj.2021.v11.i4.3

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…In addition to the evaluation of tumor invasion, other relevant histopathological information was obtained from each case. Papillary infiltrative UC was considered the most prevalent histological subtype in this study, agreeing with the results of Govoni et al 54 . Regarding tumor differentiation, 20 cases (95%) in this study were classified as conventional UC, while only one case was classified as divergent UC.…”

Section: Discussionsupporting

confidence: 93%

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Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Rangel,

Linhares,

de Oliveira

et al. 2023

Sci Rep

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Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.

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Section: Discussionsupporting

confidence: 93%

“…Recently, lymphatic invasion has been proposed as a relevant negative prognostic factor for canine UC 54 . In the present study, only four cases showed lymphatic invasion and due to this small sample size, it is difficult to determine whether this feature affected the OS of the dogs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Rangel,

Linhares,

de Oliveira

et al. 2023

Sci Rep

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“…Canine BUCs can invade adjacent tissues and organs, such as the ureter, prostatic urethra, and prostate gland, and moreover, the tumor can spread by means of vascular and lymphatic vessels [ 12 , 21 , 22 ]. Lymphatic invasion has recently been proven to be a significant negative prognostic factor [ 10 ]. However, metastases may occur with or without the observation of vascular invasion in the primary neoplasm [ 12 , 14 ].…”

Section: Canine Bucs: Histological Descriptionmentioning

confidence: 99%

“…Bladder urothelial carcinoma (BUC) is an important human disease worldwide, with more than 400,000 new cases per year [ 8 , 9 ]. Dogs with invasive BUCs were recently proposed as a “large animal” model for the study of their human counterparts because they show similar morphology and metastasis locations [ 10 ]. Moreover, BUCs comprise 1.5–2% of all naturally occurring cancers in dogs—a rate similar to that reported in humans [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Grading Systems for Canine Urothelial Carcinoma of the Bladder: A Comparative Overview

Brambilla

Govoni²,

Cavalca³

et al. 2022

Animals

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The relationship between tumor morphology and clinical behavior is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based on standardized parameters to predict patient prognosis. Dogs with bladder urothelial carcinoma (BUC) were recently proposed as a “large animal” model for the study of human BUCs due to the similar morphology and metastasis locations. BUC grading systems are consolidated in human medicine, while in veterinary medicine, the BUC grading systems that have been proposed for canine tumors are not yet applied in routine diagnostics. These latter systems have been proposed, decade by decade, over the last thirty years, and the reason for their scarce application is mainly related to a lack of specific cutoff values and studies assessing their prognostic relevance. However, for any prognostic study, reliable grading is necessary. The aim of the present article was to give an overview of the BUC grading systems available in both human and veterinary pathology and provide an extensive description and a critical evaluation to support veterinary researchers in the choice of possible grading systems to apply in future studies on canine BUCs.

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“…In a previous study, our research group identified an association between lymphatic invasion and poor prognosis in canine UC ( 33 ). Because some of the samples used were also used in this study, we did not associate survival with lymphatic invasion to avoid data duplication.…”

Section: Discussionmentioning

confidence: 93%

Caveolin-1, GATA-3, and Ki67 expressions and their correlation with pathological findings in canine bladder urothelial carcinoma

et al. 2022

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The bladder urothelial carcinoma (UC) represents ~2% of malignant neoplasms in dogs and is a therapeutic challenge in veterinary medicine. Although it is considered the most common bladder cancer in dogs, few previous studies have investigated different markers that correlate with clinical and pathological parameters. Therefore, this study aimed to evaluate Caveolin-1, GATA-3, and Ki67 immunostaining in canine UC samples to evaluate their correlations with histopathological variables. Thirty tumor samples were obtained, and Caveolin-1, GATA-3, and Ki67 expression was assessed by immunohistochemistry and associated with pathological factors by univariate and multivariate analyses. Among the histopathological findings, lymphatic invasion was identified in 53.33% of the tumors, and the mean mitotic count (MC) was 31.82 ± 26.26. Caveolin-1 showed mild-to-high cytoplasmic expression in neoplastic cells, whereas GATA-3 showed mild-to-high nuclear expression. The Ki67 expression revealed a mean of 24.14 ± 16.88% positive cells. In the univariate analysis, no association was found between each marker and the pathological findings. On the other hand, in multivariate analysis, we identified a positive correlation between GATA-3 and MC and a negative correlation between Caveolin-1 and MC. Moreover, lymphatic invasion was positively correlated with histological type and grade, and negatively correlated with MC. In addition, the histological type was positively correlated with the histological grade. Overall, our results indicate that Caveolin-1 and GATA-3 expression could be promising markers for bladder UC aggressiveness.

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Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

Cited by 4 publications

References 25 publications

Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Grading Systems for Canine Urothelial Carcinoma of the Bladder: A Comparative Overview

Caveolin-1, GATA-3, and Ki67 expressions and their correlation with pathological findings in canine bladder urothelial carcinoma

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