Lymphatic Drainage in Prostate Carcinoma assessed by Lymphoscintigraphy and SPECT/CT: Its importance for the Sentinel Node Procedure

Bonilla-Damiá, A. de; Brouwer, O.R.; Meinhardt, W.; Valdés-Olmos, R.A.

doi:10.1016/j.remnie.2012.04.001

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…The most frequent drainage site was the common iliac region (31 %), followed by the internal iliac (20 %), the obturator fossa (18 %), the external iliac (15 %), and the promontory/presacral area (6 %) [125]. A similar presacral SLN rate (5.4 %) was found in another study concerning 18 patients with prostate cancer of intermediate prognosis; in this series also para-aortic (5.4 %), pararectal (5.4 %), and paravesical (3.6 %) SLNs were found outside the area of extended pelvic lymphadenectomy [126]. In the operating room, innovations in the SLN procedure for prostate cancer have been illustrated in recent years by the use of portable gamma camera to facilitate laparoscopic SLN biopsy [4] and the incorporation of robot-assisted SLN procedures [60].…”

Section: Urological Malignanciessupporting

confidence: 86%

Radioguided Surgery: Novel Applications

Olmos¹,

Orsini²,

Giammarile³

et al. 2016

Nuclear Oncology

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A few years ago, the concept guided intraoperative scintigraphic tumor targeting (GOSTT) was introduced to encompass the whole spectrum of basic and advanced nuclear medicine procedures required for providing a roadmap for radioguided surgery. This concept included the use of interventional nuclear medicine imaging to depict targets to be resected by radioguided surgery. With the incorporation of SPECT/CT and PET/CT, three-dimensional roadmaps to guide surgical procedures became possible. On the other side, new intraoperative portable imaging devices (gamma cameras and other tools) were added to conventional modalities such as gamma probes and blue dye. More recently, the development of hybrid tracers integrating radioactivity and fluorescence in one single signature has enabled the additional use of near-infrared cameras. All these advances have facilitated the extension of radioguided sentinel lymph node biopsy procedures from the classical applications in cutaneous melanoma and breast cancer to other fields such as oral cavity, gastrointestinal, urological, and gynecological malignancies. At present, three GOSTT working models can be defined in relation to radiotracer administration: intralesional without tracer migration for occult lesion localization, intralesional with tracer migration for occult lesion localization and sentinel lymph node biopsy, and systemic to enable excisional biopsy of primary lesions and recurrences as well as isolated regional and distant metastases. The latter is probably the field with the largest potential due to the continuous introduction of new PET and SPECT tracers. Novel modalities like luminescence detection and tracked image-guided navigation will further reinforce the role of GOSTT and radioguided intervention procedures.

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Section: Urological Malignanciessupporting

confidence: 86%

Radioguided Surgery: Novel Applications

Olmos¹,

Orsini²,

Giammarile³

et al. 2016

Nuclear Oncology

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“…While it is generally accepted that a limited nodal dissection removes the obturator package and the standard dissection additionally involves dissection of the external iliac nodes, there is no standardization or universally accepted operative template regarding the extended lymph node dissection. In these situations, often, urologists will dissect the obturator, external iliac, hypogastric (internal iliac) and common iliac nodes; however, additional nodes in presacral, paraaortic, pararectal and paravesical regions can be involved and dissected as illustrated in lymphoscintigraphic studies of the prostate . These studies have confirmed the lymphatic drainage of the prostate to be unique and that different nodal groups can be affected independently of each other with authors reporting that up to 40% of lymph nodal involvement (LNI) can be missed with a limited node dissection alone …”

Section: Discussionmentioning

confidence: 99%

Extended pelvic lymph node dissection for clinically localized prostate cancer: a West Australian experience

Picardo

Vivian

2015

ANZ Journal of Surgery

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“…106 The SLN rate outside the lymphadenectomy area increases in patients previously treated with radiotherapy or surgery for prostate cancer to an 80% in comparison with a 34% for untreated patients. 107,108…”

Section: Prostate Cancermentioning

confidence: 99%

Using lymphoscintigraphy as a prognostic tool in patients with cancer

Vidal-Sicart¹,

Olmos²

2016

RRNM

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Early detection of metastatic involvement of lymph nodes is one of the greatest difficulties faced by the physicians. In the last few centuries, the lymphatic system has become an important field of interest in oncology. The lymphatic system functions in two opposing ways in cancer: defense against circulating tumor cells, and, on the other hand, a route for metastasis and a site of tumor growth when the defense mechanism fails. The significant impact of lymphatic dissemination on the staging, treatment, and outcome of solid cancers has stimulated investigations aimed at gaining more insight into several aspects of the lymphatic system. Its application in oncology has evolved in the last 50 years fostered by the recognition of the relationship of lymph node metastases to prognosis in several types of malignant tumors. Lymphatic mapping also offers the opportunity for repetitive studies undertaken for evaluation of the patient during follow-up, thereby offering early evidence of recurrence of the disease. More recent and widespread applications of lymphoscintigraphy form the basis for biopsy of the sentinel lymph node in patients with solid cancers. This article reviews the applications of lymphoscintigraphy in the current diverse oncologic clinical indications for the assessment of secondary lymphedema related to oncologic treatments and sentinel lymph node lymphatic mapping.

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Lymphatic Drainage in Prostate Carcinoma assessed by Lymphoscintigraphy and SPECT/CT: Its importance for the Sentinel Node Procedure

Cited by 5 publications

References 19 publications

Radioguided Surgery: Novel Applications

Radioguided Surgery: Novel Applications

Extended pelvic lymph node dissection for clinically localized prostate cancer: a West Australian experience

Using lymphoscintigraphy as a prognostic tool in patients with cancer

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