Lymphadenopathy of Kimuraʼs Disease

Hui, Pui Wah; Chan, John K. C.; Ng, C.S.; Kung, I. T. M.; Gwi, E.

doi:10.1097/00000478-198903000-00001

Cited by 133 publications

(81 citation statements)

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“…Kimura disease is endemic in Asia, and therefore many cases have been collected and reviewed in Asian countries [1][2][3], while it occurs only infrequently in non-Asian populations [4]. In general, KD tends to affect young adults, with patient age ranging from 1 to 72 years, with a mean age of 32.8 years, and shows a striking male predilection (M:F = 5:1).…”

Section: Discussionmentioning

confidence: 99%

“…In general, KD tends to affect young adults, with patient age ranging from 1 to 72 years, with a mean age of 32.8 years, and shows a striking male predilection (M:F = 5:1). A subcutaneous mass in the head and neck region or a mass in the major salivary glands is the usual presentation, often being associated with regional lymphadenopathy [1][2][3][4][5][6]. Occasionally, lymph node enlargement is the only manifestation.…”

Section: Discussionmentioning

confidence: 99%

“…It characteristically consists of cellular (increased eosinophils and follicular hyperplasia), fibrocollagenous, and vascular (proliferation of the postcapillary venule) components. Other features include eosinophilic microabscesses, eosinophilic folliculolysis, germinal center (GC) necrosis, proteinaceous deposits in GC, polykaryocytes of the Warthin-Finkeldey type within GC, and IgE reticular staining in GC [1,2,4]. Findings may be basically non-specific and may cause some difficulty in making a histological diagnosis, particularly when the tissue sample is small, such as when obtained by biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Yamamoto

Minamiguchi

Watanabe

et al. 2013

Head and Neck Pathol

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Kimura disease (KD) affecting an unusual site is a diagnostic challenge. We report herein the case of a 62-yearold Japanese woman who presented with swelling of the epiglottis, resulting in airway narrowing. Microscopically, biopsied and resected specimens both revealed lymphoid proliferation of a reactive immunophenotype, accompanied by vascular proliferation, eosinophilic infiltration, and stromal sclerosis. Adjunctive immunohistochemistry with immunoglobulin E in addition to laboratory and histological findings led us to seriously consider a diagnosis of KD. The patient underwent surgical removal with postoperative steroid therapy and has no evidence of recurrence. Our experience suggests that KD is potentially fatal as well as showing difficulty in the histological diagnosis when occurring in the upper respiratory tract, such as the epiglottis. A literature review disclosed that our case is the 11th case so far reported in this location, and that KD of the epiglottis did not show any male preponderance, as seen in other places.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Yamamoto

Minamiguchi

Watanabe

et al. 2013

Head and Neck Pathol

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“…[1][2][3][4] The disease typically presents with insidious onset of painless subcutaneous masses with adenopathy in the head and neck region. 3,4,7 The disease usually involves subcutaneous tissues, lymph nodes (periauricular, axillary, and inguinal), 7,8 parotid and submandibular salivary glands, 9 and rarely, oral mucosa. 10 Other unusual sites of involvement include the auricle, 11 scalp, and orbit.…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease: A Diagnostic Challenge

Shetty¹,

Beaty²,

McGuirt

et al. 2002

Pediatrics

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Kimura’s disease is a rare inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. We describe an 11-year-old Asian boy with Kimura’s disease who presented with a chronic left neck mass. The diagnosis was based on the characteristic histopathologic findings after surgical excision in conjunction with peripheral eosinophilia and elevated serum immunoglobulin E levels. Pediatricians in western countries should be aware of the clinical presentation of Kimura’s disease.

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“…[11][12][13] All pathological sections presented similar histopathological features. One pathologist established the diagnosis, which was confirmed by another experienced pathologist on the basis of the following characteristic features: lymphoid tissue follicular proliferation, various degrees of proliferated vasculature and fibrosis as well as the scatter of eosinophils, lymphocytes, and mast cells' infiltration.…”

Section: Methodsmentioning

confidence: 99%

Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease

Chen

Gong

et al. 2017

International Journal of Oral and Maxillofacial Surgery

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Objective To investigate the expressions of interleukin (IL)-21 and phosphorylated extracellular signal regulated kinase 1/2 ( pERK1/2) in Kimura disease (KD) and to correlate the findings with clinical and prognostic variables. Methods Immunohistochemical analysis of IL-21 and pERK1/2 was performed in 18 cases of KD and five gender-and age-matched control samples. Clinical data were extracted and patients followed up for a mean period of 32.1 months.Results After a mean follow-up period of 32.1 months (range 1-102 months), recurrence was diagnosed as the end point for seven patients-that is, a 44% (7/16) cumulative recurrence rate. In comparison with genderand age-matched controls, patients showed strong in situ expressions of IL-21 and pERK1/2, respectively ( p<0.05). Patients with strong IL-21 staining intensity and overexpression of pERK1/2 had a lower recurrence rate than those with moderate staining intensity ( p=0.049, p=0.019, respectively). However, differences were not statistically significant by gender, age, eosinophils, location, multiplicity, laterality, size, duration and primary outbreak. pERK1/2 was the independent prognostic factor ( p=0.020), while age, gender, eosinophils, multiplicity, laterality, size, duration, primary outbreak and expression of IL-21 were not. Conclusions This study suggests that the IL-21/pERK1/ 2 pathway is activated in KD, and pERK1/2 might be considered as a potential prognostic indicator in KD.

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Lymphadenopathy of Kimuraʼs Disease

Cited by 133 publications

References 0 publications

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Kimura’s Disease: A Diagnostic Challenge

Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease

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