Lymph Nodes

Chang, Karen L.; Arber, Daniel A.; Weiss, Lawrence M.

doi:10.1016/b978-1-4160-3966-2.00041-2

Cited by 5 publications

(8 citation statements)

References 438 publications

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“…There is a polymorphous cellular background which is comprised predominantly of small round lymphocytes but histiocytes, eosinophils, plasma cells, neutrophils and fibroblast are also seen. These background cells show no cellular atypia 14. The biopsy of mediastinal mass from our patient also revealed heterogenous cellular infiltrate, comprising of small lymphocytes, plasma cells and histiocytes.…”

Section: Discussionsupporting

confidence: 53%

“…The diagnosis of classic HL is made by identification of Reed–Sternberg cells (R–S cells) and variants (Hodgkin cells) in a characteristic cellular milieu 14. Thus, attention to the atypical cells as well as to the background non-neoplastic cells is necessary for the appropriate histologic diagnosis of HL.…”

Section: Discussionmentioning

confidence: 99%

“…The paranucleolar chromatin is clear, and the nuclear membrane is thick. Various picturesque terms like ‘owl’s eye or pennies on a platter’ are used to describe different appearances of R–S cells 14. Mononuclear variants are similar to classic R–S cells but have single nucleus and a large eosinophilic nucleolus.…”

Section: Discussionmentioning

confidence: 99%

“…Results of testing for CD3 are almost always negative in R–S cells. Using only these five markers (CD15, CD30, CD45/45RB, CD20, CD3), one can resolve most (>90%) cases of classic HL 14. The major difference between classical and lymphocyte predominant HL is R–S cells are CD15+ and CD30+ in classical HL and they are CD15−, CD30− and CD20+ in lymphocyte predominant HL 9.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Rizvi¹,

Zaman

Zaidi

et al. 2012

Case Reports

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Rizvi¹,

Zaman

Zaidi

et al. 2012

Case Reports

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“…1,2 These proliferations can histologically mimic malignant lymphoma, especially classical Hodgkin lymphoma (CHL), and lead to erroneous diagnoses. 1,2 These proliferations can histologically mimic malignant lymphoma, especially classical Hodgkin lymphoma (CHL), and lead to erroneous diagnoses.…”

mentioning

confidence: 99%

Variable Expression of B-cell Transcription Factors in Reactive Immunoblastic Proliferations

Treetipsatit

Rimzsa

Grogan

et al. 2014

American Journal of Surgical Pathology

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Reactive immunoblastic proliferations can histologically mimic classical Hodgkin lymphoma (CHL), and show diffuse CD30 expression in large cells. The lack of expression of CD15 in a subset of CHL further complicates their separation from immunoblastic proliferations. Loss of expression of B-cell transcription factors is frequently exploited in making a diagnosis of CHL; however, the staining patterns of B-cell transcription factors in immunoblastic proliferations have not been extensively studied. Thirty-three cases of reactive immunoblastic proliferations were evaluated using a panel of immunohistochemistry for CD30, CD15, CD20, CD3, κ, λ, CD45RB, MUM1, PAX5, OCT2, and BOB.1, as well as Epstein-Barr virus (EBV)/EBV-encoded ribonucleic acid in situ hybridization. A newly developed dual-color chromogenic in situ hybridization technology for detection of κ/λ mRNAs was also used. The majority of immunoblasts expressed CD30 in 14 of 33 (42%) cases; none expressed CD15. Loss or weak expression of at least 1 transcription factor in B immunoblasts, most commonly PAX5, was noted in 24 of 29 (83%) cases. A polytypic light chain expression pattern was detected by immunohistochemistry in 14 of 22 (63.6%) cases and by dual-color chromogenic in situ hybridization in 9 of 10 (90%) cases studied. EBV-encoded ribonucleic acid was detected in 8 of 33 (24.2%) cases, 5 of which were clinically unrelated to infectious mononucleosis. We conclude that B-cell transcription factors can show loss or weak expression in a significant proportion of reactive immunoblastic proliferations, and, therefore, staining for B-cell transcription factors together with CD30 should be interpreted with caution before a diagnosis of CHL is made.

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Prevalence and Predictors of Bacterial Contamination in Excisional Lymph Node Biopsies

Hergott

Craig

Hornick

et al. 2021

American Journal of Surgical Pathology

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Routine tissue handling exposes lymph node specimens to microbial contamination that can confound microbiological culture results and interfere with diagnosis. The scope and impact of this problem remain poorly understood. We combined over 13 years of lymph node pathology, culture data, and patient records to define the prevalence, predisposing factors, microbiology, and clinical management of false-positive lymph node cultures at a large academic medical center. Nearly one third (31.9%) of 216 cultured lymph nodes yielded bacterial growth. Approximately 90% of positive bacterial cultures grew 1 of 2 common skin-resident taxa—coagulase-negative Staphylococcus and Cutibacterium acnes—with well-documented predispositions for contamination in other clinical settings. Lymph nodes excised from axillary, cervical, and inguinal regions yielded higher positive culture rates than nodes excised from the mediastinum, suggesting proximity to the skin surface may increase contamination risk. Accordingly, cultures from thoracoscopic pulmonary resections displayed contamination rates over 5-fold lower than those from percutaneously accessed lymph nodes. Lymph nodal tissue allocated for culture in the operating room yielded unexpectedly high contamination rates, significantly higher than cultures sent from the frozen section processing area. A significant minority of contamination events were noted in the clinical record and prompted antibiotic therapy on multiple occasions. Collectively, our results illuminate the risk factors contributing to bacterial contamination and argue that routine lymph node bacterial cultures provide minimal clinical benefit for adult patients. This widespread bacterial contamination also warrants cautious implementation of increasingly sensitive molecular microbiology tools for excised tissues.

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Lymph Nodes

Cited by 5 publications

References 438 publications

Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Variable Expression of B-cell Transcription Factors in Reactive Immunoblastic Proliferations

Prevalence and Predictors of Bacterial Contamination in Excisional Lymph Node Biopsies

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