Lymph node preparation in resected colorectal carcinoma specimens employing the acetone clearing method

Vogel, C.; Kirtil, Tülin; Oellig, Frank; Stolte, Manfred

doi:10.1016/j.prp.2007.08.015

Cited by 35 publications

(46 citation statements)

References 20 publications

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“…The benefit of using an acetone-based clearing method has been proved in colon cancer. Vogel et al showed an average additional identification of 4.4 lymph nodes in comparison to the manual method (38). A recent survey showed that only 43% of pathologists use fat clearing solutions, such as acetic acid (39).…”

Section: Factors Related To Pathological Handling: Procedures For Lymmentioning

confidence: 99%

N staging: the role of the pathologist

Marco¹,

Biondi²,

Ricci³

2017

Transl. Gastroenterol. Hepatol.

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Gastric cancer is the second cause of cancer-related mortality worldwide. Metastases, including lymph nodes ones, heavily influence the prognosis of this disease. The pathological detection of positive lymph nodes is pivotal for an optimal prognostication and clinical management of affected individuals.Several factors influence the pathological investigation of surgical specimens, ultimately affecting the number of retrieved lymph nodes and, with it, the reliability of N staging. The pathologist plays a central role in optimizing this process. Factors influencing lymph node retrieval and analysis will be herein reviewed, together with the procedures adopted for an optimal pathological analysis of lymph nodes in gastric cancer.

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Section: Factors Related To Pathological Handling: Procedures For Lymmentioning

confidence: 99%

N staging: the role of the pathologist

Marco¹,

Biondi²,

Ricci³

2017

Transl. Gastroenterol. Hepatol.

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“…The mean length of colorectal cancer surgical specimens was 28.1 cm (range, 9-118 cm; median, 25 cm). The mean number of lymph nodes recovered from different locations was as follows: cecum (n = 19.3; median, 19), ascending colon (n = 24.6; median, 23), transverse colon (n = 23.4; median, 21), descending colon (n = 19; median, 18), sigmoid and rectosigmoid junction (n = 18.7; median, 16), and rectum (n = 15.4; median, 13). The mean number of total lymph nodes sampled was significantly higher in the ascending and transverse colon and significantly lower in the rectum (P b .0001).…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, Canessa et al [15] showed that the mean number of lymph nodes found in colorectal cancer surgical specimen varies from 12.4 to 73.7 when a fat-clearing technique is used and from 6.2 to 36 with manual dissection alone. Hence, the minimum recommended number of 12 lymph nodes cannot be guaranteed for every colorectal cancer surgical specimen [19]. Indeed, the average number of lymph nodes examined per specimen is often lower than the minimum recommended number, suggesting that a large number of patients with colorectal cancer are staged inadequately [3,17,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the average number of lymph nodes examined per specimen is often lower than the minimum recommended number, suggesting that a large number of patients with colorectal cancer are staged inadequately [3,17,20,21]. In some studies, up to 78% of patients with colorectal cancer have had less than the minimum required number of lymph nodes staged [3], a situation that may require the use of special techniques (such as acetone clearing) to try to reach the minimum required number of lymph nodes [19]. However, do at least any 12 lymph nodes have to be staged no matter what the circumstances?…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nodal staging in colorectal cancer: should distant lymph nodes be recovered in surgical specimens?

et al. 2009

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“…Lymph node assessment is an important prognostic factor in CRC (24). An inverse relationship was found between prognosis and the number of positive lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Effect of neoadjuvant chemoradiation on local control and disease-free survival in locally advanced rectal neoplasms

Kurt¹,

Karğı²,

Tiryaki³

et al. 2015

Turk J Bioch

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Amaç: Lokal ileri rektum kanserlerinde tedavinin temelini cerrahi oluştuşturmakla beraber neoadjuvan kemoradyoterapi (KRT) ile lokal ileri rektum kanserlerinde tümör boyutunda küçülmeye bağlı küratif rezeksiyon ve sfinkter koruyucu cerrahi yapılabilirliğinin arttığı bildirilmiştir. Bu çalışmanın amacı, neoadjuvan KRT aldıktan sonra cerrahi tedavi yapılan hastalarda rekürrens, hastalıksız /hastalıklı sağkalım ve buna etki eden faktörlerin araştırılmasıdır. Sonuç: Hiperfraksiyone RT mezorektumun sınırlarını sterilize eder ve tümör hücre kalıntılarının gelişmesini engeller. Bu durum lokal nüks ihtimalini azaltır ve muhtemelen tümör hücrelerinin uzak organlara giderek metastaz yapmasını da engellemiş olur. Neoadjuvan KRT sonrası yapılacak ideal ameliyat tekniği Total mezorektal eksizyon' dur. Cevaplanması gereken önemli soru ise KRT sonrası ideal ameliyat zamanlamasının ne olduğudurÇalışmamızda olgu sayısının az olması ve takip süresinin kısa olması nedeni ile uzun dönem neoadjuvan kemoradyoterapi uygulanan lokal ileri rektum kanserli hastalarda nüks, sağkalım/ hastalıksız sağkalımın uzun dönem takip sonuçlarının anlaşılması için başka çalışmalara ihtiyaç vardır.Objective: Although surgery comprises the basis for the treatment of locally advanced rectal cancer, the feasibility of curative resection and sphincter-sparing surgery depending on the reduction in tumour size has been reported to increase with neoadjuvant chemoradiation (CRT) in patients with locally advanced rectal cancer. The aim of this study was to investigate recurrence, survival with disease/disease-free survival and factors affecting them in patients who underwent surgery after receiving neoadjuvant CRT. Method: The files of 79 patients aged older than 18 years who were diagnosed with locally advanced rectal cancer and underwent surgery after receiving neoadjuvant CRT between January 2007 and May 2012 were retrospectively analysed in terms of demographics and clinical, radiological and pathological data. Results: A total of 79 patients, among whom 27 (34.2%) were females and 52 (65.8%) were males, were included in the study, and the mean age was 60.82±5 years. The complete regression rate after neoadjuvant CRT was 15.18%. The average follow-up period of the patients was 26 months (range: 3-59 months). During the follow up, tumour recurrence was detected in 28 (35.44%) patients, among whom 12 had local recurrence and 17 had systemic recurrence; the survival rate of the patients was 83.54%. The disease-free survival rate was 72.15%. In most of the patients, stage regression and the reduction of tumour size were achieved. Conclusion: In summary, hyperfractionated radiotherapy sterilises the margins of the mesorectum and prevents the development of tumour cell remnants, thus reducing the likelihood of local recurrence and preventing tumour cells from metastasising to remote organs. The ideal surgical technique after neoadjuvant CRT is total mesorectal excision. The important question is the optimum time for surgery after CRT. Thus, further studi...

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Lymph node preparation in resected colorectal carcinoma specimens employing the acetone clearing method

Cited by 35 publications

References 20 publications

N staging: the role of the pathologist

N staging: the role of the pathologist

Nodal staging in colorectal cancer: should distant lymph nodes be recovered in surgical specimens?

Effect of neoadjuvant chemoradiation on local control and disease-free survival in locally advanced rectal neoplasms

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