Lymph Node Metastases from Laryngeal and Pharyngeal Carcinomas: Calculation of Burden of Metastasis and its Impact on Prognosis

Jakobsen, John; Hansen, Olfred; Jørgensen, Karsten; Bastholt, Lars

doi:10.1080/028418698430467

Cited by 49 publications

(29 citation statements)

References 20 publications

(30 reference statements)

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“…We found a high incidence of nodal metastases (61%), which has also been observed in other studies (20,21). This contrasts with the more moderate incidence of onethird in carcinomas of the oral cavity and 3% of the glottic larynx.…”

Section: Discussioncontrasting

confidence: 54%

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Johansen

Grau²,

Overgaard

2000

Acta Oncologica

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Section: Discussioncontrasting

confidence: 54%

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Johansen

Grau²,

Overgaard

2000

Acta Oncologica

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“…In another study among early tongue carcinoma patients, the recurrence rate after elective neck dissection vs. observation was 9% and 47%, respectively (17). Thus, active treatment of the neck seems warranted (26,27). During follow up, only two of the patients treated with curative intent presented with distant metastases as the only site of disease (Fig.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

et al. 2003

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“…The presence of cervical lymph node metastases is an important prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC) as this significantly worsens the treatment outcome [1][2][3][4][5][6][7][8]. Radiological imaging plays an increasingly important role in accurate assessment of the lymph node status of the neck.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy and additional value of diffusion-weighted imaging for discrimination of malignant cervical lymph nodes in head and neck squamous cell carcinoma

et al. 2009

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Introduction The aim was to determine the diagnostic accuracy and additional value of diffusion-weighted imaging for detection of malignant lymph nodes in head and neck squamous cell carcinoma.Methods Two hundred nineteen lymph nodes, predominantly smaller than 10 mm (95.4%), in 16 consecutive patients were evaluated at 1.5 T. Lymph nodes were evaluated for maximum short axial diameter, morphological criteria, and apparent diffusion coefficient (ADC) values (b=0 and b=1,000 s/mm 2 ). Sensitivity, specificity, positive and negative predictive values as well as diagnostic odds ratios (DORs) and areas under the curves (AUCs) of ROC curves were calculated for the various magnetic resonance imaging (MRI) criteria individually and in combination. Histological examination of lymph nodes in the neck dissection specimen was the gold standard to determine malignant involvement. Results The optimal ADC threshold was 1.0×10 −3 mm 2 /s. Using this cutoff point, sensitivity and specificity were 92.3% and 83.9%, respectively. When used in combination with size and morphological criteria, ADC value <1.0× 10 −3 mm 2 /s was the strongest predictor of presence of metastasis (DOR=97.6). A model which added ADC values to the other MRI criteria performed significantly better than a model without ADC values: AUC=0.98 versus AUC=0.91 (p=0.036). Conclusion In this study, with predominantly small lymph nodes, the ADC criterion is the strongest independent predictor of presence of metastasis. The use of ADC values in combination with the other MRI criteria significantly improves the discrimination between malignant and benign lymph nodes.

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Lymph Node Metastases from Laryngeal and Pharyngeal Carcinomas: Calculation of Burden of Metastasis and its Impact on Prognosis

Cited by 49 publications

References 20 publications

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

Diagnostic accuracy and additional value of diffusion-weighted imaging for discrimination of malignant cervical lymph nodes in head and neck squamous cell carcinoma

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