Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

Surviving Hypopharynx–Larynx Carcinoma in the Era of IMRT

“…Outcome in locoregionally advanced laryngeal carcinoma (LC) and particularly in hypopharyngeal carcinoma (HC) after conventional radiation techniques is known for modest disease control (1)(2)(3)(4)(5)(6) and considerable treatment-related late toxicity (7)(8)(9)(10)(11)(12)(13)(14)(15). Our previous data on early outcome in our first consecutive 29 HC patients treated with simultaneously integrated boost (SIB) intensity-modulated radiotherapy (IMRT) (included in this recent analysis) showed encouraging results (16).…”

IMRT in Hypopharyngeal Tumors

“…In historical HC series, the 3-to 5-year disease-specific survival rates range from ~ 40 up to 70% [2,3,6,11,15,17,18,20,21,24,26,27,30]; Garden et al [8] found a 2-year LC of 89% and 77% for HC stage T1 and T2, respectively, in 82 HC patients; Nakamura et al [23] reported a 5-year disease-specific survival of 90% in 43 stage I/II HC patients.…”

“…Locoregional disease control rates of approximately 40-70% [2,3,6,11,15,17,18,20,21,24,26,27,30] or even less [4,9,13] are reported for hypopharyngeal cancer (HC) patients receiving three-dimensional conventional radiation therapy (3DCRT) ± chemotherapy, while late-term dysphagia rates range between 40% and 75% in the majority of published articles [1,6,19,20,28]. The main challenge in conventional irradiation of HC is an appropriate dose coverage mainly to the dorsal aspect of the tumor and the boost planning target volume (PTV1), respectively, which is often close to or overlaps the spinal cord in the lateral-beam projection used for 3DCRT.…”

Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity

“…There has been only a moderate improvement over the past few decades (Platz et al, 1985;De Vicente et al, 2001;Gourin and Johnson, 2001;Schmelzeisen, 2002;Luukkaa et al, 2003). Tumours spread into the adjacent regions and all therapeutic interventions may detract from the patients aesthetic appearance.…”