Lymph node density as an independent prognostic factor in node‐positive patients with tonsillar cancer

Park, Jun‐Ook; Joo, Young‐Hoon; Cho, Kwang-Jae; Kim, Min-Sik

doi:10.1002/hed.24074

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…HPV status of tonsil cancer was provided but not analysed separately. As well as in the presented study, Park et al23 could prove LNR (>0.05) and ECS to be significant predictors of prognosis of OS in univariate analysis. In multivariate analysis, LNR did not reach the level of significance (P=.059) to predict OS 23.…”

supporting

confidence: 79%

“…As well as in the presented study, Park et al23 could prove LNR (>0.05) and ECS to be significant predictors of prognosis of OS in univariate analysis. In multivariate analysis, LNR did not reach the level of significance (P=.059) to predict OS 23. This aspect might be due to less importance of occurrence and extent of locoregional metastasis of HPVpositive OPSCC in accordance to our study.…”

supporting

confidence: 79%

“…Park et al . reviewed a cohort of 64 patients with tonsillar cancer regarding prediction of prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…In univariate and multivariate analyses, LNR could be shown to be a significant predictor of OS with a cut-off LNR of 0.0909 and 0.1. 14 Park et al23 reviewed a cohort of 64 patients with tonsillar cancer regarding prediction of prognosis. HPV status of tonsil cancer was provided but not analysed separately.…”

mentioning

confidence: 99%

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The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

Meyer

Meinrath

Seehawer

et al. 2017

Clinical Otolaryngology

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supporting

confidence: 79%

supporting

confidence: 79%

“…Park et al . reviewed a cohort of 64 patients with tonsillar cancer regarding prediction of prognosis.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

Meyer

Meinrath

Seehawer

et al. 2017

Clinical Otolaryngology

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“…Cervical nodal status with primary head and neck malignancy has vital prognostic significance demanding workup and thorough management of cervical nodal disease. 11,12 RND was the most widely used procedure to deal with neck metastasis, however this has been widely debated. RND, which was popularized by Dr. Hayes Martin 6 , involves enblock removal of lateral neck nodes with superficial and deep layers of deep cervical fascia, including submandibular, deep cervical, supraclavicular and posterior triangle nodes and lymphatics along with sternomastoid muscle, internal jugular vein and accessory nerve 7 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy/ Validity of Neck Dissection and Radiotherapy for Cervical Nodal Disease - Clinicopathological Analysis

Umar

Ahmed

Saqulain

2019

JIMDC

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Objective: To analyze treated head and neck malignancies with reference to frequency of cervical metastases and frequency of nodal recurrence following neck dissection and/ or radiotherapy for cervical metastases.Patients and Methods: This observational prospective study was conducted at ENT Department, Pakistan Institute of Medical Sciences, Islamabad over a period of 16 months. Study population was comprised of 15 cases of either gender and any age, with treated head and neck primary who developed metastatic neck disease and were included through non-probability sampling technique. Patients with primary site recurrence or distant metastases were excluded from the study. They were treated with neck dissection, radiotherapy or both for neck disease and followed up for a 1 year. Clinical data including age, gender, site and histopathology of treated primary tumor, nodal involvement both clinical and histopathological, treatment and post treatment result were recorded. Data was collected, tabulated and analyzed using Microsoft excel worksheet.Results: Out of total 15 cases, 17% patients were with N1 disease, 33% patients with N2a disease, and 50% were with N2b disease. Total 3 (20%) patients received radiotherapy (2 being unfit for surgery and 1 due to refused consent) and 12 (80%) patients underwent surgery. Out of these 12, 3 underwent RND, 7 MRND and 2 SND. Total 20% (3) developed recurrence.Conclusion: Combination of RND or MRND and radiotherapy is highly effective in controlling neck disease in controlled primary tumors.

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Prognostic value of lymph node ratio versus American Joint Committee on Cancer N classification for surgically resected human papillomavirus‐associated oropharyngeal squamous cell carcinoma

2021

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Background We compared prognostic values of lymph node ratio (LNR) and AJCC 8 N classification in surgically resected human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (OPSCC). Methods Using the National Cancer Database, we identified patients with HPV‐associated OPSCC from 2010 to 2016 who underwent definitive surgical resection. Patients were analyzed by nodal grouping (LNR, N stage) and adjuvant radiation therapy(RT). Primary endpoint was overall survival. Results We identified 4166 patients. Survival analysis showed significant improvement for LNR≤6% versus >6% (5 year OS% 92.7% vs. 83.7%, p < 0.001). N classification demonstrated good prognostic ability (5 year OS% for pN0, pN1, pN2 were 91.3%, 90.1%, 78.8%, p < 0.001), but poor separation among stages (compared to pN0: pN1 HR 1.40 [95% CI 0.63, 3.09], p = 0.41; pN2 HR 2.50 [95% CI 1.08, 5.81], p = 0.033). RT improved survival in the LNR > 6% group (5 year OS% 85.4% vs. 74.9%, p < 0.001; HR 0.41 [95% CI 0.28, 0.58], p < 0.001). Conclusions LNR should be considered an adjunct category in future staging systems for HPV‐associated OPSCC.

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Lymph node density as an independent prognostic factor in node‐positive patients with tonsillar cancer

Abstract: Lymph node density might be useful as an independent predictor of survival in patients with tonsillar cancer and positive lymph nodes. © 2015 Wiley Periodicals, Inc. Head Neck 38: E705-E711, 2016.

Cited by 7 publications

References 22 publications

The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

Efficacy/ Validity of Neck Dissection and Radiotherapy for Cervical Nodal Disease - Clinicopathological Analysis

Prognostic value of lymph node ratio versus American Joint Committee on Cancer N classification for surgically resected human papillomavirus‐associated oropharyngeal squamous cell carcinoma

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