Lymph Flow and Contractile Activity of Mesenteric Lymph Nodes in Rats with Toxic Hepatitis Effects of Antioxidants

Абдрешов, С. Н.; Bulekbayeva, L. E.; Demshenko, G. A.

doi:10.1007/s10517-013-2070-z

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…A slow perfusion rate of 40 μL min −1 was used to mimic the relatively slow lymphatic flow through the tissue. 43 Prior literature has suggested that flow through tissue slices on-chip, improves viability and function of ex vivo slices, compared to traditional perfusion chambers which flow across the tops of tissue slices. 44,45 This supports the use of the track-etched membranes to facilitate flow through the tissue slices.…”

Section: Resultsmentioning

confidence: 99%

Open multi-organ communication device for easy interrogation of tissue slices

Delong

Ross

2023

Lab Chip

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Section: Resultsmentioning

confidence: 99%

Open multi-organ communication device for easy interrogation of tissue slices

Delong

Ross

2023

Lab Chip

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“…In all probability, follicular hyperplasia after the occurrence of inflammation in the abdominal organs of the body is the most common type of lymph node reaction and is characterized by increases in follicles and the expansion of the reproduction centers. This type of lymph node is known to be capable of performing its functions effectively [ 64 , 65 ], and lymph nodes play important roles as active barriers to prevent the spread of pathogens along the lymphatic tract [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Abdreshov,

Demchenko,

Yeshmukhanbet

et al. 2024

Biology

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This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.

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