Lyme disease

Bhate, Chinmoy; Schwartz, Robert A.

doi:10.1016/j.jaad.2010.03.047

Cited by 30 publications

(5 citation statements)

References 148 publications

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“…The Centers for Disease Control and Prevention (CDC) proposed a two-step approach for serological testing in order to identify active disease or past infections. An ELISA or immunofluorescent antibody test (IFA) is recommended as the first-line test, after which western blot (WB) is required as a second-line confirmatory test ( 6 , 7 , 8 ). The IgM and/or IgG antibodies occur in only 20–50% of patients in the early localized stage.…”

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confidence: 99%

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Cora¹,

Kaklıkkaya²,

Topbaş³

et al. 2017

Balkan Med J

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Background:Lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in Turkey even though studies on its seroprevalence are limited.Aims:To determine the seroprevalence of Lyme borreliosis in part of north-eastern Tur-key (in the city of Trabzon), and to identify possible relationships between seropositivity and various factors such as location, gender, age group, occupation, income, and educational level.Study Design:Retrospective cross-sectional study.Methods:A total of 884 blood samples collected from provincial and district health centers serving a population of about 800,000 were included in this study. ELISA was used to determine the anti-Borrelia IgG antibody levels in the samples. Samples that yielded positive results by ELISA were further subjected to western blot (WB).Results:IgG antibodies were found in 128 samples (14.5%). Statistical analysis revealed significant differences between age groups and educational levels in terms of the incidence of seropositivity, whereas location, gender, occupational group and income level had no effect (p<0.001, p<0.001, p=0.948, p=0.645, p=0.131, p=0.080 respectively).Conclusions:The risk of contracting Lyme borreliosis in Trabzon is high, and necessary measures need to be taken to avoid the spread of disease.

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confidence: 99%

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Cora¹,

Kaklıkkaya²,

Topbaş³

et al. 2017

Balkan Med J

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“…Importantly, about 10-20% of patients (especially those who are diagnosed later), following appropriate antibiotic treatment, may have persistent or recurrent symptoms and are considered to have "post-treatment Lyme disease syndrome" [13]. In some cases, other microorganisms may be cotransmitted through the tick bite [8,12,14]. Patients found to have coinfections should be treated with appropriate therapies.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, for uniformity, a 14-day course of therapy is advised for all of the first-line oral agents [11]. Doxycycline is generally preferred since it has the advantage of being also effective for treatment of human granulocytic anaplasmosis and Borrelia lonestari and Borrelia miyamotoi infections (but not for babesiosis), which may occur simultaneously with early LD; however, it is contraindicated in children <8 years of age and during pregnancy or lactation [11,14,16]. Cefuroxime axetil is usually considered as a second-line treatment because of its cost [14].…”

Section: Introductionmentioning

confidence: 99%

“…Doxycycline is generally preferred since it has the advantage of being also effective for treatment of human granulocytic anaplasmosis and Borrelia lonestari and Borrelia miyamotoi infections (but not for babesiosis), which may occur simultaneously with early LD; however, it is contraindicated in children <8 years of age and during pregnancy or lactation [11,14,16]. Cefuroxime axetil is usually considered as a second-line treatment because of its cost [14]. Two small studies found that doxycycline (100 mg twice-daily) and amoxicillin (500 mg three times a day, plus probenecid at the same dose), both administered for ten days in one study and for three weeks in another, had a comparable efficacy in the treatment of early localized LD [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Therapy of Lyme Disease

Trevisan¹,

Errichetti²,

Meo³

et al. 2016

TODJ

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Borrelia burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Antibiotic selection, dose and route of administration, and duration of therapy for Lyme disease depend on the patient's clinical manifestations and stage of disease, age, pregnancy status, as well as the presence of other concomitant diseases and/or allergies. Despite an appropriate antibiotic therapy, about 10-20% of patients may show persistent or recurrent symptoms ("post-treatment Lyme disease syndrome").In the present paper we will briefly discuss the post-exposure prophylaxis, before going on to talk over the current therapeutic approach regarding the management of Lyme disease according to the stage of disease/clinical manifestations. Finally, we will discuss the main treatment-related phenomenon, the Jarisch-Herxheimer reaction, and the treatment modalities for special categories of patients, namely pregnant women, subjects suffering from post-treatment Lyme disease syndrome, possible Borrelia-associated skin manifestations, coinfections and Baggio-Yoshinary syndrome.

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“…The case definition has become more complex as more knowledge has been gained regarding disease symptom expression and testing specificity and validity [10]. Specificity of testing, complexity of required testing, and the absence of laboratory markers early in LD onset also contribute to inadequate diagnosis of LD, thus affecting LD incidence [11,12]. The deficient knowledge of LD incidence rates may also be attributed to misdiagnosis of symptoms or the lack of recognition of late development of symptoms by providers [13,14].…”

Section: Introductionmentioning

confidence: 99%

Provider Knowledge, Attitudes, and Practices Regarding Lyme Disease in Arkansas

Hill

Holmes

2014

J Community Health

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Lyme disease (LD), a vector-borne disease, causes illness for many individuals in the United States. All of the conditions for the promulgation of LD are present in one Southern state in the United States; yet this state reports lower numbers of LD than adjacent states. The purpose of this study was to determine associations between this Southern state's primary care providers' knowledge and attitudes regarding the diagnosis and reporting of LD. A quantitative, cross-sectional study was conducted via a mailed questionnaire by the Arkansas Department of Health to 2,693 primary care providers. Respondents were 660 primary care providers from all regions of this state. Secondary data were analyzed using descriptive, Chi square, and logistic regression techniques. Analysis results included the following: a correct response rate of 59.1 % for symptom recognition, of 46.2 % for knowledge of recommended testing processes, and of 78.9 % for knowing LD is a reportable disease. These results compared to the expected norm were significant in every area with p values of .000. Specialty, region, and years of practice were found to be confounding influences in a number of assessment areas.

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Lyme disease

Cited by 30 publications

References 148 publications

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Therapy of Lyme Disease

Provider Knowledge, Attitudes, and Practices Regarding Lyme Disease in Arkansas

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