Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model

Ardawi, M. S. M.; Badawoud, Mohammed H.; Hassan, Sherif; Rouzi, Abdulrahim A.; Ardawi, Jumanah M.S.; AlNosani, Nouf M.; Qari, Mohammed H.; Mousa, Shaker A.

doi:10.1016/j.bone.2015.10.017

Cited by 53 publications

(49 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, Iimura et al, [44] showed that lycopene intake by ovariectomized rats facilitates the increase of bone mineral density and bone strength. This was in consistent with Ardawi et al, [45] , who stated that, in an ovariectomized mice model, lycopene can help against the loss of bone mass, that primarily suppressed bone turnover to restore bone strength and microarchitecture, improving bone biomechanical properties with an increase in both antioxidant enzyme activity and osteoblast activity.…”

Section: Discussionsupporting

confidence: 89%

Histological Study of the Possible Protective Effect of Lycopene on Glucocorticoid-Induced Osteoporosis in Adult Male Albino Rat

Tawfik¹,

Salah

2019

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Osteoporosis is one of the most commonly occurring bone diseases characterized by decrease in bone mass and increase bone resorption leading to fractures, severe pain and deformities. Glucocorticoid-induced osteoporosis results from long-term and high dose use. Lycopene is an unsaturated carotenoid that gives tomatoes and other fruits their red color. It was reported that it is a natural antioxidant and was associated with the prevention of many chronic diseases and cancers. Aim of Study: This work was performed to study the possible protective effect of lycopene against glucocorticoidinduced osteoporosis in adult male albino rat. Material and Methods: 40 adult male albino rats were used that divided equally into four main groups: Group I (control group) was subdivided equally into two subgroups (I-A & I-B), Group II received lycopene orally 30mg/kg once daily for 8 weeks, Group III received prednisolone orally 20mg/kg once daily for 8 weeks, Group IV concomitantly received lycopene and prednisolone orally once daily at the same previous doses for 8 weeks. At the end of experiment, femur heads of all animals were obtained and processed for histological study and stained with Hematoxylin & eosin, Mallory Trichrome and for scanning electron microscope study. Results: Light microscopic examination revealed structural changes in femur head of Group III in the form of discontinuous thin trabeculae of cancellous bone with apparent faintly stained matrix with multiple pores inside trabeculae associated with minor fractures, wide bone marrow spaces were seen between trabeculae containing abundant clear areas, the endosteal surface showed irregular eroded surface. Regarding Mallory stained sections; they showed decrease collagen fibers contents with their irregular distribution in bone matrix. Scanning electron microscopic specimens showed discontinuous thin and blind ended cancellous bone trabeculae containing some areas of decreased electron density with multiple pores and minor fractures inside them. Wide bone marrow spaces were seen between trabeculae lined with irregular eroded endosteal surface; which revealed the evident of prednisolone induced osteoporosis. Group IV specimens revealed partial preservation

show abstract

Section: Discussionsupporting

confidence: 89%

Histological Study of the Possible Protective Effect of Lycopene on Glucocorticoid-Induced Osteoporosis in Adult Male Albino Rat

Tawfik¹,

Salah

2019

The Medical Journal of Cairo University

View full text Add to dashboard Cite

show abstract

“…Free radicals can oxidize lipids and proteins, thus causing cell damage and altered function [ 97 , 98 ]. Reactive oxygen species suppress differentiation and proliferation of osteoblasts and are significantly involved in osteoclast differentiation and bone resorption [ 99 , 100 ]. Menopause increases oxidative stress; thus, the oxidized microenvironment produced by ROS plays a major role in causing postmenopausal osteoporosis [ 85 , 99 , 101 ].…”

Section: Postmenopausal Osteoporosis: a Silent Diseasementioning

confidence: 99%

“…Reactive oxygen species suppress differentiation and proliferation of osteoblasts and are significantly involved in osteoclast differentiation and bone resorption [ 99 , 100 ]. Menopause increases oxidative stress; thus, the oxidized microenvironment produced by ROS plays a major role in causing postmenopausal osteoporosis [ 85 , 99 , 101 ]. Antioxidants are directly involved in the scavenging process of ROS.…”

Section: Postmenopausal Osteoporosis: a Silent Diseasementioning

confidence: 99%

“…More recently, lycopene supplementation in ovariectomized rats was found to significantly alter levels of biomarkers of bone turnover in blood and urine, reducing bone resorption and increasing osteoblast activity. Simultaneously, lycopene treatment increased the enzyme action of glutathione peroxidase, catalase, and superoxide dismutase, and downregulated oxidative stress [ 99 ]. Taken together, these animal studies suggest that lycopene has bone-protective benefits ( Table 3 ).…”

Section: Evidence Of the Effect Of Lycopene On Bone Healthmentioning

confidence: 99%

See 1 more Smart Citation

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

Walallawita

Wolber

Ziv‐Gal

et al. 2020

IJMS

View full text Add to dashboard Cite

Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density, which affects the quality of life of the aging population. Furthermore, disruption of bone microarchitecture and the alteration of non-collagenous protein in bones lead to higher fracture risk. This is most common in postmenopausal women. Certain medications are being used for the treatment of osteoporosis; however, these may be accompanied by undesirable side effects. Phytochemicals from fruits and vegetables are a source of micronutrients for the maintenance of bone health. Among them, lycopene has recently been shown to have a potential protective effect against bone loss. Lycopene is a lipid-soluble carotenoid that exists in both all-trans and cis-configurations in nature. Tomato and tomato products are rich sources of lycopene. Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. However, there are still limited studies that have evaluated the effect of lycopene on the prevention of bone loss in postmenopausal women. Therefore, the aim of this review is to summarize the relevant literature on the potential impact of lycopene on postmenopausal bone loss with molecular and clinical evidence, including an overview of bone biology and the pathophysiology of osteoporosis.

show abstract

“…Osteoporosis is one of the most representative bone metabolism disorders [32]. To evaluate the possible functional significance of TRAF4 in bone metabolism in vivo, we produced OVX rats as an animal model of postmenopausal osteoporosis [33]. The results of both micro-CT (Fig.…”

Section: Traf4 Is Decreased In Bone Sections Of Osteoporotic Rats Andmentioning

confidence: 99%

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

Wang

Xie

et al. 2019

Cell Death Differ

View full text Add to dashboard Cite

TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system. Mesenchymal stem cells (MSCs), which are the primary origin of osteoblasts in vivo, are key cells in bone development; however, whether TRAF4 modulates the osteogenic capacity of MSCs has never been explored. In this study, we demonstrated that TRAF4 positively regulates the osteogenic process of MSCs both in vitro and in vivo. In addition, we further demonstrated that TRAF4 modulates the osteogenic process of MSCs by acting as an E3 ubiquitin ligase to mediate the K48-linked ubiquitination of Smurf2 at the K119 site and cause degradation. Furthermore, TRAF4 was abnormally decreased in bone sections of ovariectomized rat and osteoporosis patients. Taken together, our findings suggest that TRAF4 positively regulates the osteogenic differentiation of MSCs by acting as an E3 ubiquitin ligase to degrade Smurf2. These results emphasize the critical role of TRAF4 in bone formation and could not only improve the clinical use of MSCs in tissue engineering but also clarify the pathogenesis of bone metabolism disorders.

show abstract

Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model

Cited by 53 publications

References 57 publications

Histological Study of the Possible Protective Effect of Lycopene on Glucocorticoid-Induced Osteoporosis in Adult Male Albino Rat

Histological Study of the Possible Protective Effect of Lycopene on Glucocorticoid-Induced Osteoporosis in Adult Male Albino Rat

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

Contact Info

Product

Resources

About