Lycopene supplementation attenuates western diet-induced body weight gain through increasing the expressions of thermogenic/mitochondrial functional genes and improving insulin resistance in the adipose tissue of obese mice

Wang, Jia; Suo, Yao; Zhang, Jinlei; Zou, Qianhui; Tan, Xiao Di; Tian, Yuan; Liu, Zhigang; Liu, Xuebo

doi:10.1016/j.jnutbio.2019.03.008

Cited by 40 publications

(30 citation statements)

References 41 publications

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“…Focusing on adipose tissues, early studies showed that ATRA, as well as β-carotene and other provitamin A carotenoids, increases uncoupling protein 1 (UCP1) and, thus, the capacity for energy expenditure through enhanced BAT thermogenic function (186) . More recently, fucoxanthin (224) , β-cryptoxanthin (225) , lycopene (226) , ATRA (227,228) and retinal (209) have been shown to stimulate WAT oxidative capacity and features of WAT browning, which may also contribute to greater energy expenditure. Effects in adipose tissues most likely result from the combination of direct action of the carotenoids/ retinoids in these tissues and their systemic effects.…”

Section: Carotenoids and Obesitymentioning

confidence: 99%

Mechanistic aspects of carotenoid health benefits – where are we now?

et al. 2021

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Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain related diseases and some types of cancer. However, intervention trials with isolated carotenoid supplements have mostly failed to confirm the postulated health benefits. It has thereby been speculated that dosing, matrix and synergistic effects, as well as underlying health and the individual nutritional status plus genetic background do play a role. It appears that our knowledge on carotenoid-mediated health benefits may still be incomplete, as the underlying mechanisms of action are poorly understood in relation to human relevance. Antioxidant mechanisms – direct or via transcription factors such as NRF2 and NF-κB - and activation of nuclear hormone receptor pathways such as of RAR/RXR or also PPARs, via carotenoid-metabolites, are the basic principles which we try to connect with carotenoid-transmitted health benefits as exemplified with described common diseases including obesity/diabetes and cancer. Depending on the targeted diseases, single or multiple mechanisms of actions may play a role. In this review and position paper, we try to highlight our present knowledge on carotenoid metabolism and mechanisms translatable into health benefits related to several chronic diseases.

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Section: Carotenoids and Obesitymentioning

confidence: 99%

Mechanistic aspects of carotenoid health benefits – where are we now?

et al. 2021

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“…Several comorbidities were concomitantly reduced, such as glucose tolerance, insulin sensitivity and steatosis [45]. We and others have confirmed this beneficial effect of lycopene and/or tomato powder rich in lycopene in a DIO mice model on adiposity, glucose homeostasis, adipose tissue and liver inflammation and steatosis [46,47,48,49].…”

Section: Carotenoids And/or Metabolites Are Involved In Body Weighmentioning

confidence: 69%

“…The browning of white adipose tissue has been proposed as a putative mechanism controlling energy homeostasis and insulin sensitivity [104]. Recently, an AMPK-mediated effect on adipocyte browning and mitochondrial biogenesis was demonstrated for zeaxanthin [105] and for lycopene [49]. We reported similar mitochondrial biogenesis, induction of oxidative phosphorylation (OXPHOS) and adipocyte browning in adipocytes incubated with ATRA [106], whereas fucoxanthin and its metabolite fucoxanthinol were inefficient in inducing adipocyte browning [107].…”

Section: Carotenoids And/or Metabolites Impact Adipocyte Biology Imentioning

confidence: 99%

Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects

2019

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This review summarizes current knowledge on the biological relevance of carotenoids and some of their metabolites in obesity management. The relationship between carotenoids and obesity is considered in clinical studies and in preclinical studies. Adipose tissue is a key organ in obesity etiology and the main storage site for carotenoids. We thus first describe carotenoid metabolism in adipocyte and adipose tissue and the effects of carotenoids on biological processes in adipose tissue that may be linked to obesity management in in vitro and preclinical studies. It is also now well established that the brain is strongly involved in obesity processes. A section is accordingly devoted to the potential effect of carotenoids on obesity via their direct and/or adipose tissue-driven indirect biological effects on the brain.

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“…Accordingly, lycopene is a lipophilic antioxidant with an open straight-chain hydrocarbon consists of mainly 11 conjugated and 2 non-conjugated double bonds, which can interrupt the chain reaction of lipid peroxidation and to quench peroxyl radicals [6]. Similarly supported by Wang et al [7], lycopene illustrated a protective effect by the inhibition of lipogenesis and improvement of insulin resistance in the obese mice.…”

Section: Introductionmentioning

confidence: 89%