Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ

Microbial transformation of the diterpene mulin‐11,13‐dien‐20‐oic acid by Mucor plumbeus

“…[26] To the best of our knowledge, this is the first report of tyrosol production by M. plumbeus. Tyrosol was reported to prevent NF-κB, IRF-1 (Interferon regulatory factor-1) and STAT-1α (Signal transducer and activator of transcription-1α) activation and pro-inflammatory genes, [27] not to exert cytotoxic effects on cells derived from the buccal mucosa [28] and act as a hydroxyl radical scavenger and antioxidant. [29,30] The diterpenes described in Apiaceae have very unusual skeletons that have been found only in Azorella, Mulinum, and Laretia genus.…”

Inhibitive effect of purple sweet potato leaf extract and its components on cell adhesion and inflammatory response in human aortic endothelial cells

“…1,12,13 In RAW 264.7 macrophages induced by gliadin and IFN-γ, quercetin decreased inducible NOS (iNOS) activity. 30 Moreover, consumption of PSPL for 7 d reduced exercise-induced oxidative damage and pro-inflammatory cytokine secretion. 31 Further studies will be undertaken to evaluate the effects of PSPLE and its components on the levels of ROS generated in an in vivo model of atherogenesis.…”

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

“…Moreover, the inflammatory signaling induced by LPS and TNF cytokines is mediated via ROS-dependent signaling [128]. Several studies have demonstrated that lycopene can inhibit NF-kB signaling [129,130]. Lycopene, for instance, can inhibit nuclear localisation and DNA binding of NF-kB complex, as well as reducing macrophage activation [129].…”