Inhibitive effect of purple sweet potato leaf extract and its components on cell adhesion and inflammatory response in human aortic endothelial cells

Chao, Pi-Yu; Huang, Ya‐Ping; Hsieh, Wen-Bin

doi:10.4161/cam.23649

Cited by 53 publications

(46 citation statements)

References 42 publications

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“…This result is in contrast with Chao et al. who showed that pretreatment with a phenolic‐rich extract from purple sweet potato leaf extract (100 μg/mL) lowered TNF‐α‐induced monocyte adhesion to human aortic endothelial cells. In a previous study, Chang et al.…”

Section: Discussioncontrasting

confidence: 96%

Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment

Bò

Roursgaard

Porrini

et al. 2016

Molecular Nutrition Food Res

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Section: Discussioncontrasting

confidence: 96%

Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment

Bò

Roursgaard

Porrini

et al. 2016

Molecular Nutrition Food Res

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“…It was reported that the isolated anthocyanins inhibit the progress of atherosclerotic injury and enhancements of oxidative status and vascular adhesion molecule-1 in mice [23]. The leaves extract purple I. batatas showed inhibitive effect on cell adhesion and inflammatory mediation in endothelial cells of human aorta [24]. Hence; it is probable that the enhancement of endothelial dysfunction effect of MGE may be referred to its bioactive phenolic secondary metabolites as anthocyanins, flavonoids, and other flavonoids derivatives content [7].…”

Section: Discussionmentioning

confidence: 99%

“…With respect to inflammatory markers CRP, TNF-α and IL-10 in control and different treated groups; CRP and TNF-α levels in hyperlipidemic diabetic rats recorded percentage increase reached to 85.93 and 50.99%, respectively, while significant decrease in IL-10 (49.86%) as compared to normal control rats. It was suggested that, inflammations have a crucial intermediary role in pathogenesis Type 2 diabetic, thereby inflammatory mechanisms can lead to joining diabetes with a number of commonly coexisting conditions [1,17,24]. TNF-α has been demonstrated as a marker of insulin resistance [2].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Aly

Abd‐Alla²,

Ali³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research in bioinformatics focuses on pharmacological effects of morning glory and necklace pod ethanolic extracts (MGE and NPE) on some biochemical parameters in high fat diet-induced hypercholesterolemia and streptozotocin-induced hyperglycemia in rats.Methods: Compared to atorvastatin; an anti-hypercholesterolemic (HC) and glibenclamide; an antidiabetic drug. Endothelium activation markers of soluble vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 were determined using enzyme-linked immunosorbent assay. Creatinine, urea, and inflammatory biomarkers; C-reactive protein (CRP) and pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin (IL)-10 levels were also measured in serum of different therapeutic groups.Results: Significant decrease in ICAM-1 level with MGE and NPE supplemented to normal rats as compared to untreated control with percentages decrease 17.80 and 12.00% was observed. Insignificant change was detected in VCAM-1 level. Profound amelioration in CRP, total urea and creatinine levels by NPE treatment. Creatinine, urea, CRP, and TNF-α level were significantly increased in hyperglycemic (HG)-HC rats. However, IL-10 level showed a significant decrease. Meanwhile, histopathological investigation of the kidney and heart was carried out. Image recognition system for kidney and heart images was developed to diagnose their diseases. Tested extract attenuated creatinine, urea, CRP, and TNF-α level. Hyperglycemia and hypercholesterolemia linked kidney disorders were relieved. Conclusion:In vivo oral administration with each extract declared suppression of cytokines mediated inflammation, vascular function leading to infiltration reduction of renal macrophage together with lowering in kidney indices and ameliorate renal tissues architectures in HG-HC rats.

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“…In light of the strong interplay between inflammation, age-associated diseases and longevity (Baylis et al 2013; Chung et al 2009; Demartinis et al 2006; Franceschi 2007; Vasto et al 2007) or inflammaging, as aptly coined by Franceschi and colleagues (Franceschi et al 2000) it is of particular interest that the sweet potato (including the leaves) has been shown to have significant anti-inflammatory properties (Chao et al 2013; Hwang et al 2001; Shan et al 2009; Wang et al 2010; Zhang et al 2009) as well as strong anti-oxidant effects (Dini et al 2006; Hou et al 2001; Hwang et al 2001; Johnson & Pace 2010; Kano et al 2005;; Zhang et al 2009). - Although human interventional studies and clinical trials are necessary to confirm the promising preliminary work in vivo and in vitro, it should also be noted that sweet potatoes are also good sources of B vitamins, including folate, thiamine, riboflavin, and vitamin B6.…”

Section: Differences Between the Traditional Okinawan And Japanese Dietsmentioning

confidence: 99%

Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet

Willcox

Scapagnini

Willcox

2014

Mechanisms of Ageing and Development

202

121

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The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes), green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods, lean meats, fruit, medicinal garnishes and spices, tea, alcohol are also moderately consumed. Many characteristics of the traditional Okinawan diet are shared with other healthy dietary patterns, including the traditional Mediterranean diet, DASH diet, and Portfolio diet. All these dietary patterns are associated with reduced risk for cardiovascular disease, among other age-associated diseases. Overall, the important shared features of these healthy dietary patterns include: high intake of unrefined carbohydrates, moderate protein intake with emphasis on vegetables/legumes, fish, and lean meats as sources, and a healthy fat profile (higher in mono/polyunsaturated fats, lower in saturated fat; rich in omega-3). The healthy fat intake is likely one mechanism for reducing inflammation, optimizing cholesterol, and other risk factors. Additionally, the lower caloric density of plant-rich diets results in lower caloric intake with concomitant high intake of phytonutrients and antioxidants. Other shared features include low glycemic load, less inflammation and oxidative stress, and potential modulation of aging-related biological pathways. This may reduce risk for chronic age-associated diseases and promote healthy aging and longevity.

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Inhibitive effect of purple sweet potato leaf extract and its components on cell adhesion and inflammatory response in human aortic endothelial cells

Cited by 53 publications

References 42 publications

Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment

Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet

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