Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes

Xia, Jun; Lin, Jianhua; Zhu, Shi-Yong; Du, Zheng-Hai; Guo, Jing-Ao; Han, Zixuan; Li, Jinlong; Zhang, Ying

doi:10.1016/j.etp.2015.12.004

Cited by 29 publications

(18 citation statements)

References 66 publications

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“…As expected, broiler chickens exposed to AFB 1 and simultaneously fed diets supplemented with lycopene mitigated the alterations of AFB 1 -induced serum AST and ALT activities. These results are consistent with prior studies, which indicated that lycopene could play protective effects against liver damage induced by toxic substances including AFB 1 , ochratoxin A, atrazine in rats and mice [16,25,26].…”

Section: Discussionsupporting

confidence: 93%

“…It has been identi ed as a class A nutrient by the United Nations Food and Agriculture Organization (FAO) and WHO [13]. Furthermore, lycopene can alleviate the damages caused by various toxic substances in humans, mice and rats, which might be related to the regulation of CYP450 enzymes and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)mediated phase II detoxi cation and antioxidant systems [10,[14][15][16][17]. Poultry are especially susceptible to AFB 1 [6], and broiler chicken is one of the most common source of animal food all over the world.…”

Section: Introductionmentioning

confidence: 99%

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Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Wan

Yang

et al. 2020

Preprint

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Background Dietary constituents in certain bioactive substances may alleviate the toxicity of aflatoxin B1 (AFB1). Lycopene is a natural bioactive substance with powerful antioxidant, this study investigated whether dietary lycopene supplementation could alleviate AFB1-induced liver damage through inhibiting cytochrome P450 (CYP450) isozymes and improving detoxification and antioxidation with nuclear factor erythroid 2-related factor 2 (Nrf2) activation in broiler chickens. 320 healthy one-day-old male broiler chickens were randomly allotted into five groups and fed basal diet (Control), basal diet with AFB1 and 0, 100, 200 or 400 mg/kg lycopene, respectively. At 42 days of age, 8 broiler chickens per group were sampled.Results Compared to the control group, AFB1-exposed birds had depressed growth performance, hepatotoxicity and oxidative damage. The various lycopene levels prevented AFB1-induced growth depression, decreased activities and mRNA expressions of hepatic CYP450 isozymes, reduced reactive oxygen species and oxidative damage products, improved reduced glutathione (GSH)-dependent detoxification system and antioxidant system. Moreover, lycopene elevated the mRNA expressions of Nrf2 and its target genes, containing glutathione-s-transferase isozymes, GSH synthesis-related enzymes and antioxidases in AFB1-exposed broiler chickens.Conclusions As an effective anti-stress and hepatoprotective antioxidant, lycopene alleviated AFB1-induced liver damage possibly through inhibiting CYP450 isozymes and improving Nrf2-mediated detoxification and antioxidant systems in broiler chickens. Therefore, Lycopene and lycopene-enriched materials could be taken into consideration as effective hepatoprotective and anti-stress additives in poultry, and benefit the resulting food safety.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Wan

Yang

et al. 2020

Preprint

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“…Liver is an essential organ involved in the metabolism of exogenous toxic substance and also a primary target of ATR toxicity. It is known to cause hepatic damage in frogs, fish, birds, pigs, and rodents . The use of histologic and ultrastructural analysis allowed for the damage of target organelle in the microsomes by exposure to ATR .…”

Section: Discussionmentioning

confidence: 99%

“…It is known to cause hepatic damage in frogs, 3 fish, 4 birds, 38 pigs, 39 and rodents. 6,7 The use of histologic and ultrastructural analysis allowed for the damage of target organelle in the microsomes by exposure to ATR. 40 Previous studies reported that ATR exposure showed hepatotoxicity such as fatty change and cellular infiltration in the liver of quail.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have demonstrated that ATR induce hepatotoxicity and affect hepatic metabolism. Chronic ATR exposure results in high accumulative levels in multiple species, including frogs, fish, and rodents . Birds are one of the most important ecological pollution indicators due to their strong sensitivities to environmental pollutants .…”

Section: Introductionmentioning

confidence: 99%

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Activating nuclear xenobiotic receptors and triggering ER stress and hepatic cytochromes P450 systems in quails (Coturnix C. coturnix) during atrazine exposure

Qin

Lin

et al. 2017

Environmental Toxicology

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Atrazine (ATR) is one of the most widely detected contaminant in the ecosystem. Nuclear xenobiotic receptors are activated by herbicides and induce the transcription of CYP450 isoforms involved in xenobiotic metabolism and transport. However, little is known about hepatic nuclear xenobiotic receptors in birds are responsible for ATR-induced hepatotoxicity via regulating the cytochrome P450 enzyme systems (CYP450s). The objective of this study was to investigate the mechanism of ATR hepatotoxicity in quails. For this purpose, male quails were dosed by oral gavage from sexual immaturity to maturity with 0, 50, 250, and 500 mg/kg/day ATR for 45 days. The results showed that ATR exposure caused the hepatotoxicity damage and endoplasmic reticulum (ER) degeneration. It suggested that ER is a target organelle of ATR toxicity in hepatocytes. ATR exposure disrupted the hepatic CYP450s homeostasis. This study also demonstrated that ATR triggered the CYP450 isoforms transcription via activating the hepatic CAR/PXR pathway. The present study provides new insights regarding the mechanism of the ATR-induced hepatotoxicity through activating nuclear xenobiotic receptors and triggering ER stress and hepatic CYP450s in quails.

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Protective effect of lycopene against chemical and natural toxins: A review

et al. 2018

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People are exposed to a number of environmental, occupational, and therapeutic toxic agents which may be natural or man made. These hazardous substances may manifest as direct side effects on the function of organs or indirectly induced alteration of gene expression, cancer‐associated metabolic pathways, and/or alter homeostasis. Lycopene, as a one of the most potent antioxidant, is found in fruits and vegetables. High‐intake of lycopene has been shown to be effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides. Recently, there is growing attention in understanding the mechanisms of the phytochemicals and carotenoids as antioxidative, antiapoptotic, radical scavenging, and chelating agents and their roles in the modulation of inflammatory pathways. This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants. © 2018 BioFactors, 45(1):5–23, 2019

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Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes

Cited by 29 publications

References 66 publications

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Activating nuclear xenobiotic receptors and triggering ER stress and hepatic cytochromes P450 systems in quails (Coturnix C. coturnix) during atrazine exposure

Protective effect of lycopene against chemical and natural toxins: A review

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