Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

Sandhir, Rajat; Mehrotra, Arpit; Kamboj, Sukhdev Singh

doi:10.1016/j.neuint.2010.07.005

Cited by 138 publications

(76 citation statements)

References 86 publications

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“…It has been previously reported that lycopene has several biological functions in various diseases. Lycopene protects the cell from lipid peroxidation and oxidative DNA damage as a highly efficient antioxidant (8,9). In addition, lycopene exhibits other properties, including antiapoptosis (10), anti-inflammation (11,12), antiamyloid (13), anti-ischemia (14), and antitumor properties (15).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Lei

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. The present study aimed to investigate the neuroprotective effect of lycopene in a mouse model of bilateral common carotid artery occlusion (BCCAO) and the role of the Nrf2/HO-1 signaling pathway. A total of 60 male C57BL/6 mice, aged 12 weeks and weighing 20-24 g, were used in the present study. The mice were randomly assigned to three groups: Control, BCCAO and BCCAO + lycopene. The neurological score was assessed 24, 48 or 72 h following BCCAO. Hematoxylin and eosin staining, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were performed to detect neuronal death and survival. The production of glutathione (GSH) and reactive oxygen species were detected to investigate the oxidative stress. The expression levels of nuclear factor erythroid 2-related factor (Nrf2) and Heme oxygenase-1 (HO-1) were determined by western blotting. Lycopene significantly improved the neurological score in the BCCAO mice. It attenuated neuronal apoptosis, as indicated by TUNEL staining, and attenuated the oxidative stress induced by global ischemia. Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. The present study revealed that lycopene protects the brain from global ischemic injury, which is associated with its antiapoptotic effect and the activation of the Nrf2/HO-1 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Lei

Zhang

et al. 2015

Molecular Medicine Reports

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“…Nuestros datos muestran como el hidroxitirosol recupera los niveles de GSH y reduce el daño oxidativo evaluado como productos de lipoperoxidación. Estos hallazgos acerca del hidroxitirosol están en concordancia con los resultados previos obtenidos en otros estudios experimentales acerca de los efectos de otros polifenoles, como el resveratrol y el licopeno, que tienen capacidad neuroprotectora, con la mejora de la viabilidad mitocondrial, cognición y funciones motoras (35,36).…”

Section: Discussionunclassified

Antioxidant effect of oleic acid and hydroxytyrosol in an experimental model similar to Huntington's disease

Alconchel¹,

Santamarı́a²,

Túnez³

2014

Actual. Med.

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Efecto antioxidante del ácido oleico e hidroxitirosol en un modelo experimental similar a la enfermedad de Huntington ResumenLos radicales libres juegan un papel fundamental en la alteración neuronal que tiene lugar en enfermedades neurodegenerativas y en el envejecimiento cerebral. Se ha asociado la dieta Mediterránea con la reducción del riesgo de padecer enfermedades neurodegenerativas. Objetivos. Este estudio fue diseñado para probar si el ácido oleico y el hidroxitirosol, componentes del aceite de oliva virgen-extra, ejercen un efecto antioxidante protector en el cerebro ante el estrés oxidativo inducido por el ácido 3-nitropropiónico. Métodos. El ácido 3-nitropropiónico se administró intraperitonealmente a una dosis de 20 mg/kg de peso durante cuatro días consecutivos. El ácido oleico (con una dosis del 4% de calorías ingeridas diariamente por el animal) y el hidroxitirosol (2,5 mg/kg de peso en solución acuosa) se administraron durante 14 días a ratas Wistar. Resultados. El ácido 3-nitropropiónico causó un aumento de la peroxidación lipídica y de la actividad de la glutatión peroxidasa, y una reducción en la concentración de glutatión reducido. Los resultados obtenidos además demuestran que el ácido oleico y el hidroxitirosol reducen los niveles de los productos de peroxidación lipídica y bloquean el agotamiento del glutatión reducido en el cerebro tras la administración de ácido 3-nitropropiónico. Conclusión. Tanto el ácido oleico como el hidroxitirosol actúan como potentes antioxidantes frente al estrés oxidativo inducido por el ácido 3-nitropropiónico. AbstractFree radicals play an important role in neuronal alterations during the progression of neurodegenerative disorders and brain aging. Mediterranean-style diet has been associated to a reduction in the risk to develop neurodegenerative disorders. Objectives. This study was designed to test whether oleic acid and hydroxytyrosol, both components of extra-virgin olive oil, exert an antioxidant and protective effect in the brain subjected to oxidative stress induced by 3-nitropropionic acid. Methods. 3-Nitropropionic acid was administered intraperitoneally to animals at a dose of 20 mg/kg for 4 consecutive days. Oleic acid (given at a dose equivalent to 4% of the calories ingested every day per animal) and hydroxytyrosol (2,5 mg/kg, dissolved in aqueoussolution) were administered during 14 consecutive days to Wistar rats. Results. 3-Nitropropionic acid caused increased levels of lipid peroxidation and glutathione peroxidase activity, and a depletion in the concentration of reduced glutathione. Our findings also demonstrate that oleic acid and hydroxytyrosol reduce the levels of lipid peroxidation and prevent the depletion of reduced glutathione in the brain induced by the administration of 3-nitropropionic acid. Conclusion. Both oleic acid and hydroxytyrosol act as potent antioxidants against the oxidative damage induced by 3-nitropropionic acid.

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“…91 In an animal study, a beneficial effect of lycopene supplementation in rotenone-induced Parkinson's disease was demonstrated. 92 Lycopene showed protective effects against myeloid β-induced neurotoxicity in cultured rat cortical neurons 93 , 3-nitropropionic acid-induced mitochondrial oxidative stress, and dysfunctions in nervous system 94 , and trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons. 95 …”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Bacanlı¹,

Başaran²,

Başaran³

2017

tjps

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It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Lycopene, which belongs to the carotenoid family, is the most effective singlet oxygen scavenger in vitro of all the carotenoids. Foods that contain lycopene and related supplements have been reported to prevent chronic diseases including cancer, asthma, and cardiovascular disorders. The aim of the article was to give a brief review of the antioxidant properties and beneficial health effects of lycopene.

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Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

Cited by 138 publications

References 86 publications

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Antioxidant effect of oleic acid and hydroxytyrosol in an experimental model similar to Huntington's disease

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

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