Lycopene modulates lipid metabolism in rats and their offspring under a high-fat diet

Cao, Chunyu; Sun, Shishuai; Li, Jibo; Song, Chunsheng; Meng, Qiang; Shi, Baoming; Shan, Anshan

doi:10.1039/d1fo01039e

Cited by 11 publications

(11 citation statements)

References 61 publications

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“…The results of this study suggest that dietary LCP increases HDL levels and promotes the metabolism of serum TG and TC. This is similar to the findings of prior studies on rats [ 24 ]. Disorders of lipid metabolism include increased serum levels of TC and TG and decreased levels of HDL [ 42 ].…”

Section: Discussionsupporting

confidence: 92%

“…The addition of LCP to HLD might enhance hepatic lipid metabolism in mice [ 25 , 55 ]. Supplementing maternal meals with LCP may diminish the activity of ACC and FAS in the liver and lower blood lipid levels in rats and their offspring [ 24 ]. In the investigation of broilers, it was observed that LCP could lower the level of blood lipids and the activity of FAS and ACC in the liver [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…The utilization of LCP has been shown to be an effective strategy in mitigating the toxicity associated with its exposure in Nile tilapia ( Oreochromis niloticus ) [ 23 ]. LCP supplementation in HLD-fed rats ( Rattus norvegicus ) decreased hepatic lipid synthesis and lipid levels in both mother and progeny mice [ 24 ]. LCP was discovered in a study on nonalcoholic fatty liver disease to increase the expression of pparα [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Lycopene Alleviates the Adverse Effects of Feeding High-Lipid Diets to Hybrid Grouper (♀Epinephelus fuscoguttatus ×♂E. lanceolatus)

Zhou,

Liu,

et al. 2023

Aquaculture Nutrition

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It has been found that high-lipid diets (HLDs) disrupt lipid metabolism in fish, leading to an excessive accumulation of lipids in various tissues of the fish body. The objective of this study was to investigate if the inclusion of lycopene (LCP) in an HLD may mitigate the adverse consequences of excessive dietary lipid intake in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus). The experimental design incorporated a control group (L0), which was administered a diet consisting of 42% protein and 16% lipid. The diets for groups L1, L2, and L3 were developed by augmenting the control diet with 100, 200, and 400 mg/kg LCP, respectively. The duration of the trial spanned a period of 42 days. The results of the study showed that the weight gain rate (WGR) and protein efficiency ratio (PER) of the three LCP treatment groups (L1, L2, and L3) tended to increase and then decrease, with a significant increase in WGR and PER in L2 ( P < 0.05 ). Visceral somatic index and hepatic somatic index tended to decrease and then increase in all treatment groups, with a significant decrease in L2 ( P < 0.05 ). In serum dietary LCP significantly reduced triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) content and significantly increased high-density lipoprotein (HDL) content ( P < 0.05 ). In the liver, dietary LCP reduced TC, TG, and very LDL levels and improved lipoprotein lipase, hepatic lipase, fatty acid (FA) synthetase, and acetyl-CoA carboxylase activities. The number and area of hepatic lipid droplets decreased significantly with increasing LCP content. In the liver, the addition of appropriate levels of LCP significantly upregulated lipoprotein lipase (lpl) and peroxisome proliferator-activated receptor α (pparα). In summary, dietary LCP improves growth and reduces lipid deposition in the liver of hybrid grouper by increasing lipolytic metabolism and decreasing FA synthesis. Under the experimental conditions, the fitted curve analysis showed that the recommended LCP additions to the high lipid diet for juvenile hybrid grouper were 200–300 mg/kg.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lycopene Alleviates the Adverse Effects of Feeding High-Lipid Diets to Hybrid Grouper (♀Epinephelus fuscoguttatus ×♂E. lanceolatus)

Zhou,

Liu,

et al. 2023

Aquaculture Nutrition

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“…Myricetin significantly promoted GPX activity in high-fat diet(HFD)-fed mice, improved antioxidant capacity in vivo, and downregulated the expressions of adipogenic PPARγ and CEBPα genes in HFD-induced mice [ 25 ]. The addition of antioxidant lycopene can increase liver HSL and ATGL and promote liver lipolysis [ 26 ]. Another antioxidant had similar results in other animals or cells, reduced lipid synthesis and promoted lipolysis [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

Luo

Wen

et al. 2022

Animals

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GPX2 has been recognized as a potential candidate gene for feed efficiency in pigs. This article aimed to elucidate polymorphism of GPX2 associated with feed efficiency and its related molecular mechanism. In this study, seven single nucleotide polymorphisms (SNP) of GPX2 were found among 383 Duroc pigs. In addition, seven SNPs and ALGA0043483 (PorcineSNP60 BeadChip data in 600 Duroc pigs), which are near the GPX2 gene, were identified in one haplotypes block. Furthermore, associated studies showed that the genotype of GPX2 has significant association with weaning weight and 100 kg BF in Duroc pigs. In addition, the AG had no effect when the backfat became thinner, and the FCR and RFI traits had a tendency to decrease in the G3 + TT combination genotype, accompanied by an increase of GPX2 expression in backfat and muscle tissues. At the cellular level, the adipocyte proliferation and ability of adipogenic differentiation were reduced, and the lipid degradation increased in 3T3-L1 when there was overexpression of GPX2. In contrast, overexpression of the GPX2 gene can promote the muscle cell proliferation and myogenic differentiation in C2C12 cells. In other words, GPX2 has the effect of reducing fat deposition and promoting muscle development, and it is a candidate gene for backfat and feed efficiency.

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“…27,28 HMGCR is a rate-limiting enzyme in cholesterol synthesis in the liver. 29 Increased expression of FABP1, CD36, DGAT1, and HMGCR mRNA caused by high lipid levels indicates an increase in adipogenesis and cholesterol accumulation in the liver. While decrease in FABP1, CD36, DGAT1, and HMGCR expression caused by the Quzhi formula indicate that Quzhi formula protects against NASH via active chemicals that targeting these lipid-related genes, inhibiting the activity of transcription factors for lipid synthesis, thus inhibiting lipid accumulation.…”

Section: Chronic Imbalancementioning

confidence: 99%

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling

Wu¹,

Wu²,

Shen³

et al. 2022

J Clin Transl Hepatol

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Background and Aims:The Quzhi formula, a Chinese medicine compound prescription, relieves nonalcoholic steatohepatitis (NASH) symptoms. This study aimed to explore the mechanism of the Quzhi formula against NASH. Methods: A choline-deficient, L-amino acid-defined, high-fat diet induced a NASH mouse model and a free fatty acid-induced mouse hepatocyte cell model were used to evaluate the function of Quzhi formula in vivo and in vitro. Network pharmacology and molecular docking technology were performed to uncover the possible protective mechanisms of the Quzhi formula against NASH. Key factors in liver lipid metabolism and endoplasmic reticulum (ER) stress pathway were evaluated to verify the mechanism. Results: The positive contribution of the Quzhi formula on NASH was confirmed in vivo and in vitro. Abnormal accumulation of lipid in the liver and inflammatory responses were significantly decreased by the Quzhi formula. Network pharmacological analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the Quzhi formula protected against NASH by regulating ER stress and inflammatory responses, which was enhanced by further molecular docking analysis. In addition, mechanism exploration showed that Quzhi formula mainly reduced ER stress by downregulating Bip/ eIF2α signaling. Conclusions: The Quzhi formula protected against NASH by inhibiting lipid accumulation, ER stress, and inflammatory responses, which supports the potential use of Quzhi formula as an alternative treatment for NASH.

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Lycopene modulates lipid metabolism in rats and their offspring under a high-fat diet

Abstract: The purpose of this study was to investigate the effects of lycopene supplementation on the lipid metabolism of rats and their offsprings. The experiment was conducted on 60 female rats...

Cited by 11 publications

References 61 publications

Lycopene Alleviates the Adverse Effects of Feeding High-Lipid Diets to Hybrid Grouper (♀Epinephelus fuscoguttatus ×♂E. lanceolatus)

Lycopene Alleviates the Adverse Effects of Feeding High-Lipid Diets to Hybrid Grouper (♀Epinephelus fuscoguttatus ×♂E. lanceolatus)

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling

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