Lycopene modulates growth and survival associated genes in prostate cancer

Rafi, Mohamed; Kanakasabai, Saravanan; Reyes, Marynell D.; Bright, John J.

doi:10.1016/j.jnutbio.2013.03.001

Cited by 48 publications

(32 citation statements)

References 42 publications

(50 reference statements)

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“…The anticarcinogenic activities of Lycopene are considered to be exerted via other multiple mechanisms including protection of vital cellular biomolecules such as DNA and lipoproteins, intercellular gap junction communication, inhibition of proliferation of cancerous cells at the G0-G1 cell cycle phase and modulation of hormonal and immune systems (76)(77)(78). Lycopene has also been reported to inhibit prostate cancer cell proliferation via activation of the peroxisome proliferator-activated receptor gamma (PPARγ)liver X receptor alpha (LXRα)-ATP-binding cassette transporter 1 (ABCA1) pathway (PPARγ-LXRα-ABCA1 pathway) and modulation of the expression of genes related to growth and apoptosis such as cyclin-dependent kinase 7 (CDK7), epidermal growth factor receptor (EGFR), insulinlike growth factor-1 receptor (IGF-1R) and BCL2 (79,80).…”

Section: Lycopenementioning

confidence: 99%

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

2019

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Background/Aim: Prostate cancer is one of the most common cancers in men which remains a global public health issue. Treatment of prostate cancer is becoming increasingly intensive and aggressive, with a corresponding increase in resistance, toxicity and side effects. This has revived an interest in nontoxic and cost-effective preventive strategies including dietary compounds due to the multiple effects they have been shown to have in various oncogenic signalling pathways, with relatively few significant adverse effects. Materials and Methods: To identify such dietary components and micronutrients and define their prostate cancer-specific actions, we systematically reviewed the current literature for the pertinent mechanisms of action and effects on the modulation of prostate carcinogenesis, along with relevant updates from epidemiological and clinical studies. Results: Evidence from various recent experimental, clinical and epidemiological studies indicates that select dietary micronutrients (i.e., lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine) and zinc play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer. Conclusion: A formulation that comprises these micronutrients using the optimal, safest form and dosing should be investigated in future prostate cancer chemoprevention studies and as part of standard prostate cancer therapy.

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Section: Lycopenementioning

confidence: 99%

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

2019

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“…In addition, the protonated molecule of lycopene at m/z 537 is the most abundant ion in the positive ion APCI mass spectrum during high performance liquid chromatography—mass spectrometry (HPLC‐MS) (van Breemen and others ). In recent years, lycopene has attracted considerable attention due to its multiple potential protective effects against various chronic diseases, particularly some types of cancer (Rafi and others ; Ke and others ), cardiovascular diseases (Sesso and others ; Abete and others ; Gajendragadkar and others ) and myocardial infarction (Bansal and others ). In terms of geometrical configuration, the most abundant isomers of lycopene (Scheme ) are (all‐ E )‐lycopene and its (mono‐ Z )‐isomers, such as (5 Z )‐, (9 Z )‐, (13 Z )‐, and (15 Z )‐lycopene.…”

Section: Introductionmentioning

confidence: 99%

Lycopene: Heterogeneous Catalytic E/Z Isomerization and In Vitro Bioaccessibility Assessment Using a Diffusion Model

Sun

Yang

et al. 2016

Journal of Food Science

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Highly efficient heterogeneous catalytic E/Z isomerization of lycopene was achieved using an iodine-doped titanium dioxide (I-TiO ) catalyst prepared by sol-gel method. The effects of reaction temperature and reaction time were investigated in detail. The maximum total Z-ratio of lycopene exceeded 78% after 2 h of refluxing at 75 °C in ethyl acetate. Moreover, lycopene samples with a series of total Z-ratios were prepared and the bioaccessibility of these samples was estimated using a diffusion model, the results showed that the bioaccessibility of lycopene markedly increased conforming to a linear regression model with increasing of the total Z-ratio of lycopene from 3.6% to 78.5%. Furthermore, the specific role of the microstructure and melting point of 3.6% and 78.5% total Z-ratio of lycopene was also investigated to understand the probable mechanism for the enhanced bioaccessbility of (Z)-lycopenes.

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“…However, lycopene at 25 µM augmented the anti proliferative effects of PPARγ agonists (15d-PGJ 2 , ciglitazone, and pioglitazone), modulated PPARγ-induced apoptosis, and inhibited the expression of growth and survival-associated genes in PC3 cells. 10 Effects of lutein on the proliferation of PC3 cells were similar to those of lycopene. Lutein induced a mild decrease in proliferation, improved PPARγ agonistinduced cell-cycle arrest and apoptosis, and altered the expression of growth and apoptosis-associated biomarker genes.…”

Section: Pparγ Activation In Carotenoidinhibited Cancer-cell Prolifermentioning

confidence: 80%

Role of PPARγ in the nutritional and pharmacological actions of carotenoids

Wang¹,

Shi²,

Gu³

et al. 2016

RRBC

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Peroxisome proliferator-activated receptor gamma (PPARγ) has been shown to play an important role in the biological effects of carotenoids. The PPARγ-signaling pathway is involved in the anticancer effects of carotenoids. Activation of PPARγ partly contributes to the growth-inhibitory effects of carotenoids (β-carotene, astaxanthin, bixin, capsanthin, lutein, and lycopene) on breast cancer MCF7 cells, leukemia K562 cells, prostate cancer (LNCaP, DU145, and PC3 cells), and esophageal squamous cancer EC109 cells. PPARγ is the master regulator of adipocyte differentiation and adipogenesis. Downregulated PPARγ and PPARγ-target genes have been associated with the suppressive effects of β-carotene and lycopene on 3T3L1 and C3H10T1/2 adipocyte differentiation and adipogenesis. β-Carotene is cleaved centrally into retinaldehyde by BCO1, the encoding gene being a PPARγ-target gene. Retinaldehyde can be oxidized to retinoic acid and also be reduced to retinol. β-Carotene can also be cleaved asymmetrically into β-apocarotenals and β-apocarotenones by BCO2. The inhibitory effects of β-carotene on the development of adiposity and lipid storage are dependent substantially on BCO1-mediated production of retinoids. The effects of β-carotene on body adiposity were absent in BCO1-knockout mice. Retinoid metabolism is connected with the activity of PPARγ in the control of body-fat reserves. Retinoic acid, retinaldehyde, retinol, and β-apocarotenals exert suppressive effects on preadipocyte differentiation and adipogenesis via downregulation of PPARγ expression in cell culture. The molecular mechanisms underlying retinoic acid effects on adipose-tissue biology and the development of adiposity remain poorly understood. Adiposity can be affected by retinoids through long-lasting effects at critical developmental stages. Retinol saturase increases PPARγ-transcriptional activity and adipocyte differentiation. Other carotenoids that have been reported to suppress adipocyte differentiation and lipid accumulation in the main via modulation of PPARγ and PPARγ-target genes include astaxanthin, bixin, norbixin, β-cryptoxanthin, fucoxanthin and its metabolites, lycopene, apo-10'-lycopenoic acid, siphonaxanthin, and neoxanthin, except paprika pigments. Lutein, lycopene, and paprika carotenoids reduce proinflammatory cytokine levels by an induction of PPARγ in immune tissues and cells. Lycopene, apo-10'-lycopenoic acid, and astaxanthin might prevent atherosclerosis through modifying cholesterol metabolism via increasing PPARγ expression in macrophages.

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Lycopene modulates growth and survival associated genes in prostate cancer

Cited by 48 publications

References 42 publications

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Lycopene: Heterogeneous Catalytic E/Z Isomerization and In Vitro Bioaccessibility Assessment Using a Diffusion Model

Role of PPARγ in the nutritional and pharmacological actions of carotenoids

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Lycopene modulates growth and survival associated genes in prostate cancer

Cited by 48 publications

References 42 publications

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Lycopene: Heterogeneous Catalytic E/Z Isomerization and In Vitro Bioaccessibility Assessment Using a Diffusion Model

Role of PPAR&gamma; in the nutritional and pharmacological actions of carotenoids

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Role of PPARγ in the nutritional and pharmacological actions of carotenoids