Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats

Greish, Sahar M; Kader, Ghada Abdel; Abdelaziz, Eman Z.; Eltamany, Dalia A.; Sallam, Hanaa S.; Abogresha, Noha M.

doi:10.1016/j.sjbs.2021.02.034

Cited by 16 publications

(8 citation statements)

References 37 publications

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“…In this context, the natural or synthesized molecules with the potential to inhibit or reduce the production or interaction of AGEs and RAGEs have a great significance in current biomedical research. According to research reports, lycopene can reduce the production of AGE and RAGE, which aids in vessel protection [ 6 , 137 , 169 ]. The use of lycopene can promote the function of endothelial cells, as indicated by preclinical studies.…”

Section: Lycopene In Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension.

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Section: Lycopene In Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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“…In a comparative study, Moringa and lycopene improved oxidative stress, and male fertility markers in HFD-fed animals, yet lycopene showed higher antiantioxidant effects. This concluded that lycopene had superior effect compared to moringa in improving the male fertility parameters with possible higher attenuation of oxidative stress (Greish et al 2021).…”

Section: Discussionmentioning

confidence: 94%

“…This concluded that lycopene had superior effect compared to moringa in improving the male fertility parameters with possible higher attenuation of oxidative stress (Greish et al. 2021). This improvement may be due to anti‐inflammatory activities and free radical scavenging, as well as regenerating endogenous antioxidant defence system mechanisms (Hussein et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Moringa oleifera ethanolic extract ameliorates the testicular dysfunction resulted from HFD‐induced obesity rat model

et al. 2021

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In this study, we estimated the protective role of Moringa oleifera leaf ethanolic extract (MOLE) against obesity‐associated testicular dysfunction. Fifty male albino rats were randomly assigned to five groups (n = 10): Group I (basal diet), group II (basal diet plus MOLE orally), group III (high‐fat diet—HFD), group IV (HFD plus oral MOLE) and group V (HFD for 8 weeks followed by a basal diet plus oral MOLE for 6 weeks). The study duration extended for 14 weeks. Serum collected to investigate testosterone, FSH and LH levels. Testicular tissues were used to determine levels of SOD, glutathione, catalase and malondialdehyde. Semen was collected to estimate its quality (morphology, motility and concentration). Morphological changes in the testis were investigated by histopathological and immunohistochemical techniques. Compared with both control treatment and MOLE treatment, serum testosterone, FSH, LH, testicular enzymatic catalase, SOD, GSH, survivin immunoreactivity, sperm quality and testicular weight were all significantly decreased in rats treated with HFD, while there were significant increases in testicular malondialdehyde and caspase‐3 immunoreactivity. MOLE improved all harmful effects of HFD. Improvements were more pronounced in the protected (G 4) than the treated (G 5) group. MOLE could be a potential solution for obesity‐associated fertility problem.

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“…In a human study, tomato soup consumption at 400 g/day significantly increased seminal plasma levels of lycopene, though the effects on plasma antioxidant levels failed to reach significance [ 352 ]. As potent antioxidants, the role of carotenoids in fertility has been extensively investigated [ 345 , 348 , 353 , 354 , 355 ]. Williams et al examined the effect of lactolycopene, a combination of lycopene with whey protein, which protects lycopene from digestion, on sperm quality in a randomised placebo-controlled trial [ 354 ].…”

Section: Health Effectsmentioning

confidence: 99%

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Collins

Bowyer

Tsouza

et al. 2022

Biology

100

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This review outlines the health benefits associated with the regular consumption of tomatoes and tomato products. The first section provides a detailed account of the horticultural techniques that can impact the quality of the fruit and its nutritional properties, including water availability, light intensity, temperature, and growing media. The next section provides information on the components of tomato that are likely to contribute to its health effects. The review then details some of the health benefits associated with tomato consumption, including anticancer properties, cardiovascular and neurodegenerative diseases and skin health. This review also discusses the impact tomatoes can have on the gut microbiome and associated health benefits, including reducing the risk of inflammatory bowel diseases. Other health benefits of eating tomatoes are also discussed in relation to effects on diabetes, the immune response, exercise recovery, and fertility. Finally, this review also addresses the negative effects that can occur as a result of overconsumption of tomato products and lycopene supplements.

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Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats

Abstract: Highlights Obesity contributes to male infertility. Can lycopene or moringa improve male infertility? Tested in a rodent model of diet-induced obesity. Lycopene was superior to Moringa in improving male fertility parameters.

Cited by 16 publications

References 37 publications

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Moringa oleifera ethanolic extract ameliorates the testicular dysfunction resulted from HFD‐induced obesity rat model

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

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