Lycopene Inhibits DNA Damage and Liver Necrosis in Rats Treated with Ferric Nitrilotriacetate

Matos, Humberto Reis; Capelozzi, Vera Luíza; Gomes, Orisson Ponce; Mascio, Paolo Di; Medeiros, Marisa H. G.

doi:10.1006/abbi.2001.2611

Cited by 93 publications

(49 citation statements)

References 30 publications

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“…Similar results have also been reported in hamsters (Bhuvaneswari et al 2001). CAT activity and MDA level were not affected by lycopene in hens, as revealed by the present results (Serpeloni et al 2010;Gao et al 2013), but some papers have also reported that CAT activity was affected by carotenoids in rodents (He et al 1997;Palozza et al 2010;Sangeetha and Baskaran 2010), and MDA level was decreased by carotenoids supplementation (Dixon et al 1994;Matos et al 2001;Palombo et al 2007;Gao et al 2013), which could be attributed to time, environment, animal species, dosage, and type of carotenoids used and the oxidant stress challenge. Moreover, on day 35, lycopene significantly increased SOD, T-AOC, and GSH/GSSG in liver.…”

Section: Discussionsupporting

confidence: 64%

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Sun¹,

Ma²,

Zhang³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:Lycopene is a carotenoid present in vegetables and ripe fruit and has been proved to be the most potent antioxidant among various common carotenoids. This study assessed the effects of lycopene on performance production, tissue lycopene content, antioxidant capacity, and biochemical parameters in 720 Xing-hua breeding hens. Rice-soybean diets were supplemented with different lycopene levels: 0, 20, 40, and 80 mg/kg. Lycopene supplementation significantly increased fertilization rates in hens. Serum and egg lycopene contents and the Roche Yolk Colour Fan score increased with lycopene supplementation through day 7. In the liver, lycopene supplementation significantly increased superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and reduced glutathione to oxidized glutathione ratio (GSH/GSSG). Additionally, lycopene supplementation increased serum SOD, serum T-AOC, serum glutathione peroxidase, and serum GSH/GSSG. Lycopene addition significantly decreased total cholesterol and increased high density lipoprotein cholesterol and triiodothyroxine. It also improved fertilization rates, antioxidant capacity, and metabolism in breeding hens.

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Section: Discussionsupporting

confidence: 64%

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Sun¹,

Ma²,

Zhang³

et al. 2014

CZECH J ANIM SCI

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“…In previous studies, we have shown that lycopene can protect cultured mammalian cells against damage to biomolecules induced by Fe-NTA/ascorbate treatment (24). Furthermore, we showed a significant protective effect of lycopene against DNA oxidation, membrane damage and histopathologic changes observed in the liver of Fe-NTA-treated rats (25).…”

Section: Introductionmentioning

confidence: 58%

<a name="home"></a>Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate

Matos

Marques

Gomes

et al. 2006

Braz J Med Biol Res

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It has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a function of time after ip injection of carotenoids (10 mg kg -1 day -1 ß-carotene or lycopene) in rats. The highest total plasma concentration was reached 3 and 6 h after ip injection of lycopene or ß-carotene, respectively. After 5 days of carotenoid treatment, lycopene and ß-carotene were present in the 0.10-0.51 nmol/g wet tissue range in the prostate. Using a sensitive method to detected 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) by HPLC/EC, the level of 8-oxodGuo in rat prostate DNA was significantly higher (6.3 ± 0.6 residues/10 6 dGuo) 3 h after Fe-NTA injection compared with control rats (1.7 ± 0.3 residues/10 6 dGuo). Rats supplemented with lycopene or ß-carotene for 5 days prior to Fe-NTA treatment showed a reduction of about 70% in 8-oxodGuo levels to almost control levels. Compared with control rats, the prostate of Fe-NTA-treated animals showed a 78% increase in malondialdehyde accumulation. Lycopene or ß-carotene pre-treatment almost completely prevented lipid damage. Epidemiological studies have suggested a lower risk of prostate cancer in men reporting a higher consumption of tomato products. However, before associating this effect with tomato sauce constituents, more information is required. The results described here may contribute to the understanding of the protective effects of carotenoids against iron-induced oxidative stress.

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“…Increased levels of plasma MDA may be attributed to overproduction of reactive oxygen species or a deficiency of antioxidant defence 14 . There are studies showing that MDA levels increase in hepatic injury caused by oxidative stress 15 . The high level of MDA in the MTXC group liver tissue indicates that methotrexate gives rise to oxidative stress in hepatic tissue.…”

Section: Discussionmentioning

confidence: 99%

The effect of mirtazapine on methotrexate-induced toxicity in rat liver

Özoğul¹,

Kısaoğlu²,

Turan³

et al. 2013

ScienceAsia

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Methotrexate is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. This study conducts a biochemical and histopathological investigation into whether mirtazapine has a protective effect on methotrexate-induced hepatotoxicity in rats. Distilled water was given to a healthy group intraperitoneally. Methotrexate alone was injected in the control group, again intraperitoneally. Mirtazapine and, 1 h later, methotrexate were given to the rats in the final group. This procedure was repeated over 7 days. In the control group rats receiving methotrexate, blood AST, ALT, and LDH levels were 227 ± 3 µmol/l, 85 ± 2 µmol/l, and 357 ± 13 µmol/l, respectively. In the rats receiving mirtazapine and methotrexate, these values were 152 ± 3 µmol/l, 25 ± 1 µmol/l, and 141 ± 15 µmol/l. In the healthy rat group, AST, ALT, and LDH levels were 136 µmol/l, 20 µmol/l, and 133 µmol/l, respectively. Histopathologically, apoptotic bodies with condensed cytoplasm, peripheral, and pyknotic nuclei in the hepatocytes, focal necrosis and intense inflammation in the interstitial areas were present in the control group. In the methotrexate and mirtazapine group, there were no apoptotic bodies or inflammation, only isolated necrosis in the hepatocytes. In conclusion, mirtazapine protected the liver against methotrexate toxicity.

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Lycopene Inhibits DNA Damage and Liver Necrosis in Rats Treated with Ferric Nitrilotriacetate

Cited by 93 publications

References 30 publications

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

<a name="home"></a>Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate

The effect of mirtazapine on methotrexate-induced toxicity in rat liver

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