Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence

Cheng, Ho Ming; Koutsidis, Georgios; Lodge, John K.; Ashor, Ammar W.; Siervo, Mario; Lara, José

doi:10.1080/10408398.2017.1362630

Cited by 128 publications

(70 citation statements)

References 63 publications

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“…Lycopene has several cardiovascular beneficial effects, such as an antioxidative, antiinflammatory, anti-atherogenic, cardioprotective, and antiplatelet effect, improving endothelial function (nitric oxide bioavailability and blood flow), the metabolic profile (by impairing cholesterol synthesis) and blood pressure control (Figure 2 ) (Klipstein-Grobusch et al, 2000 ; Heber and Lu, 2002 ; Ahuja et al, 2006 ; Basu and Imrhan, 2007 ; Verghese et al, 2008 ; Kim et al, 2010 ; Kong et al, 2010 ; Riccioni et al, 2010 ; Ried and Fakler, 2011 ; Böhm, 2012 ; Wolak and Paran, 2013 ; Gajendragadkar et al, 2014 ; Naz et al, 2014 ; Müller et al, 2016 ; Cheng et al, 2017 ; Milani et al, 2017 ).…”

Section: Cardiovascular Protective Mechanismsmentioning

confidence: 99%

“…This can be explained by the insight that increased fecal excretion impairs the enterohepatic circuit of bile acids, thus increasing the conversion of cholesterol to bile acids (Verghese et al, 2008 ). The lipid lowering properties of lycopene involve also an increased activity of LDL receptors in macrophages (Li et al, 2015 ; Cheng et al, 2017 ).…”

Section: Cardiovascular Protective Mechanismsmentioning

confidence: 99%

“…A negative correlation between serum lycopene concentration and cardiovascular mortality was also found in a follow-up study with a large Japanese cohort (Ito et al, 2006 ). Many studies about the relationship between lycopene and cardiovascular risk have been conducted and, although, some of the results are inconsistent, overall dietary lycopene intake and high-serum concentration of lycopene, significantly reduced the risk of major cardiovascular events (Cheng et al, 2017 ; Song et al, 2017 ). Not all outcomes were positive, as exemplified in the Physicians Health Study, including 499 patients with cardiovascular disorders, not revealing any association of higher plasma lycopene and CVD (Müller et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Lycopene and Vascular Health

et al. 2018

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Lycopene is a lipophilic, unsaturated carotenoid, found in red-colored fruits and vegetables, including tomatoes, watermelon, papaya, red grapefruits, and guava. The present work provides an up to date overview of mechanisms linking lycopene in the human diet and vascular changes, considering epidemiological data, clinical studies, and experimental data. Lycopene may improve vascular function and contributes to the primary and secondary prevention of cardiovascular disorders. The main activity profile of lycopene includes antiatherosclerotic, antioxidant, anti-inflammatory, antihypertensive, antiplatelet, anti-apoptotic, and protective endothelial effects, the ability to improve the metabolic profile, and reduce arterial stiffness. In this context, lycopene has been shown in numerous studies to exert a favorable effect in patients with subclinical atherosclerosis, metabolic syndrome, hypertension, peripheral vascular disease, stroke and several other cardiovascular disorders, although the obtained results are sometimes inconsistent, which warrants further studies focusing on its bioactivity.

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Section: Cardiovascular Protective Mechanismsmentioning

confidence: 99%

Section: Cardiovascular Protective Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lycopene and Vascular Health

et al. 2018

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“…Lycopene is a major dietary carotenoid protecting cells against oxidative damage to lipids, proteins, and DNA [1,2].…”

Section: Introductionmentioning

confidence: 99%

Lycopene in tomatoes and tomato products

et al. 2020

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AbstractThis article focused on the content of lycopene in fresh and dried tomatoes and tomato pomace, as well as in tomato paste at different harvest times (harvest 1 – August and harvest 2 – September). The lycopene content of tomatoes and tomato products was evaluated by using high-performance liquid chromatography (HPLC). The results showed that the highest content of lycopene was estimated in the tomato paste independent of the time of harvest (211.73 mg/100 g dm in August and 184.29 mg/100 g dm in September) and the lowest content in fresh pomace (20.45 and 16.11 mg/100 g dm in August and September, respectively). Good sources of lycopene are tomato by-products, in particularly dried tomato pomace (25.11 mg/100 g dm – harvest 1 and 19.30 mg/100 g dm – harvest 2). This study showed that tomato waste can be considered as a promising source of lycopene for the production of functional foods.

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“…In a recent systematic review and meta-analysis, it was reported that the highest consumption category with the highest serum concentration of lycopene had significantly lower risk of stroke (26%), mortality (37%), and CVDs (14%), but limited or no association of lycopene with atherosclerosis, congestive heart failure or atrial fibrillation. Lycopene was not significantly associated with myocardial infarction [128]. Hereafter, more reliable clinical trials, consisting of welldesigned clinical trials, are clearly necessary using larger and longer studies to better delineate the therapeutic role of Lycopene in human.…”

Section: Clinical Studiesmentioning

confidence: 99%

Protective effect of lycopene against chemical and natural toxins: A review

et al. 2018

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People are exposed to a number of environmental, occupational, and therapeutic toxic agents which may be natural or man made. These hazardous substances may manifest as direct side effects on the function of organs or indirectly induced alteration of gene expression, cancer‐associated metabolic pathways, and/or alter homeostasis. Lycopene, as a one of the most potent antioxidant, is found in fruits and vegetables. High‐intake of lycopene has been shown to be effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides. Recently, there is growing attention in understanding the mechanisms of the phytochemicals and carotenoids as antioxidative, antiapoptotic, radical scavenging, and chelating agents and their roles in the modulation of inflammatory pathways. This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants. © 2018 BioFactors, 45(1):5–23, 2019

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Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence

Abstract: This comprehensive meta-analysis suggests that high-intakes or high-serum concentration of lycopene are associated with significant reductions in the risk of stroke (26%), mortality (37%) and CVDs (14%).

Cited by 128 publications

References 63 publications

Lycopene and Vascular Health

Lycopene and Vascular Health

Lycopene in tomatoes and tomato products

Protective effect of lycopene against chemical and natural toxins: A review

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