Lycopene and intralesional betamethasone injections in the management of oral submucous fibrosis

Singh, Dipti; Shashikanth, Mathod C; Misra, Neeta; Agrawal, Sudhanshu

doi:10.4103/0972-1363.145000

Cited by 14 publications

(9 citation statements)

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“…An improvement in MIID of 4.3±0.8mm, after biweekly Injections of 1.5ml Dexamethasone and 1500 I.U Hyaluronidase for 6 weeks; 30 6±2 mm after biweekly Injections of 1.5ml Dexamethasone and 1500 I.U Hyaluronidase for 4 weeks 18 , 9.38mm after 8 weeks treatment of intralesional Hyaluronidase injection 19 , 20 . Finally, 3.9 mm improvement in MIID was seen after 4mg (1ml) Injection Betamethasone twice weekly for 8 weeks 26 . Thus, the maximum improvement was 9.38mm.…”

Section: Resultsmentioning

confidence: 86%

Comparison of Triamcinolone Versus Platelet Rich Plasma Injection for Improving Trismus in Oral Submucous Fibrosis

Hydri¹,

Udaipurwala²,

Sheikh³

et al. 2019

J. Bahria Uni. Med. Dent. Coll.

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Objective: To compare the effect of Triamcinolone versus Platelet Rich Plasma (PRP) injection intraorally for improving trismus in Oral Submucous Fibrosis (OSMF). Study Design and setting: Randomized double-blind comparative study, conducted at ENT department of PNS Shifa Hospital, Karachi from 1st June 2015 to 30th June 2016. Methodology: Eighty patients with trismus due to oral submucous fibrosis were divided randomly into two groups, ‘A’ and ‘B’ of 40 patients each. In Group A, Inj. Triamcinolone 40mg (1 ml) was injected into the sub-mucosal plane in the retro-molar trigone area and into the fibrous bands along the soft palate on multiple sites, weekly for 6 weeks. In group B Inj. PRP 1ml weekly was administered for 6 weeks along the same site. Vernier calipers were used to precisely measure the Maximum Interincisal Distance (MIID) in cms before and after the treatment. Result: There was a male preponderance in the study group with a male to female ratio of 5.1:1. In group ‘A’ mean pretreatment MIID was 2.3±0.7 cms, while in group ‘B’, it was 2.2± 0.5 cms. After completion of 6 weeks treatment the mean MIID improved in group ‘A’ to 3.08 ± 0.8cms, and in group ‘B’ to 3.22± 0.5cms. The mean improvement in MIID in group ‘A’ was 0.783± 0.25cms compared to 1.01± 0.05 cms in group ‘B’ (p < 0.05). Conclusion: Intraoral injection of PRP is more effective than Triamcinolone in improving trismus due to OSMF

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Section: Resultsmentioning

confidence: 86%

Comparison of Triamcinolone Versus Platelet Rich Plasma Injection for Improving Trismus in Oral Submucous Fibrosis

Hydri¹,

Udaipurwala²,

Sheikh³

et al. 2019

J. Bahria Uni. Med. Dent. Coll.

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“…Thus, lycopene is considered to be an effective, safe and reliable drug in OSMF. 28 Karemore and Motwani 24 also showed a significant improvement in the tolerance to spicy foods and burning sensation with lycopene. Lycopene has also been tested in combination with several other gents and has been found to be beneficial in management of OSMF.…”

Section: Discussionmentioning

confidence: 95%

Long‐term effectiveness of lycopene in the management of oral submucous fibrosis (OSMF): A 3‐years follow‐up study

Arakeri

Patil

Maddur

et al. 2020

J Oral Pathology Medicine

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Background Long‐term follow‐ups after receiving lycopene therapy for management of oral submucous fibrosis (OSMF) are scarce. The study aimed to assess the long‐term efficacy of lycopene for management of OSMF symptoms. Methods In this prospective clinical study, 400 clinically diagnosed early OSMF patients were assessed for the efficacy of lycopene in alleviation of burning sensation (BS) and reduced mouth opening (MO) symptoms in comparison to placebo. After 1‐year follow‐up, group A (lycopene group) was divided equally into group A1 and group A2. group A1 patients were retreated with lycopene and the A2 group was followed without retreatment. After 2‐year follow‐up, the Group A2 patients were advised retreatment but not followed as most of the patient did not agree for follow‐up. However, group A1 patients were continued to follow‐up every 6 months for a total three years. Statistical analysis was by independent sample t‐test and P‐value <.05 were considered as significant. Results A statistically significant difference (P < .05) in BS and MO was found between group A and B with lycopene showing better results. At one‐year follow‐up, a statistically significant recurrence in the symptoms was found (P < .05) in the lycopene group (group A). After the second intervention, there was a statistically significant difference in the improvement of symptoms between the group A1 and A2 at 6 months and 1 year (P < .05) with group A1 (retreatment) showing better results. Conclusions Treatment with lycopene led to improvement in the symptoms of OSMF in the present study. The results highlight the importance of retreatment of lycopene for its long‐term effect on alleviation the symptoms of OSMF.

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“…The general characteristics of the included studies are listed in Supplementary Table S4 [ 6 , 14 , 18 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. A total of 2063 patients are involved in the trials with most of the trials conducted in India, 1 trial conducted in Pakistan [ 50 ] and 2 trials conducted in China [ 6 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…The clinical parameters assessed mentioned in the included randomized controlled trials consist of mouth opening, burning sensation, ulceration reduction, relief of fibrous bands, tongue protrusion, cheek flexibility, pain, speech, and swallowing difficulty. Out of 32 studies that measured mouth opening, 18 studies used vernier calipers [ 18 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 46 , 50 , 51 , 52 , 53 , 55 , 58 , 59 , 61 , 63 ], 3 studies used geometric scale/divider [ 14 , 39 , 60 ], 2 studies used sliding calipers [ 6 , 47 ], 3 studies used a metal scale/divider [ 37 , 56 , 62 ] and 7 studies did not mention any particular scale or divider [ 35 , 44 , 45 , 48 , 49 , 54 , 57 ]. Out of the 32 studies, 15 studies evaluated the burning sensation.…”

Section: Resultsmentioning

confidence: 99%

Comparative Efficacy of Interventions for the Management of Oral Submucous Fibrosis: A Systematic Review and Network Meta-Analysis

Gopinath

Hui

Veettil

et al. 2022

JPM

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Introduction: Oral submucous fibrosis (OSMF) is a chronic premalignant condition and is characterized by fibroblastic change of lamina propria and stiffness of oral mucosa. Though there are several treatment options available, the best agent is not yet identified. This study assessed the comparative efficacy and safety of medical interventions in the management of OSMF. Methods: A systematic review was performed to identify randomized controlled trials (RCTs) that compared the efficacy of interventions for OSMF with each other, or placebo. A network meta-analysis was performed, and the interventions were ranked according to their efficacy based on the surface under the cumulative ranking. (PROSPERO Registration no: CRD42021255094). Results: Thirty-two RCTs comprising 2063 patients were eligible for quantitative analysis. In terms of therapeutic efficacy in the improvement of mouth opening Oxitard, a herbal formulation was ranked as the most efficacious agent, [MD, 10.29 (95%CI 6.34–14.25)] followed by combination therapy of Lycopene with corticosteroids and hyaluronidase [MD, 7.07 (95%CI 1.82–12.31)]. For improvement of burning sensation aloe vera was ranked first [MD, 6.14 (95%CI 4.58–7.70)] followed by corticosteroids with antioxidants [MD, 6.13 (95%CI 4.12–8.14)] and corticosteroids in combination with hyaluronidase with antioxidants [MD, 5.95 (95%CI 3.79–8.11)]. In terms of safety, most of the drugs were reported to cause mild adverse effects only. Significant inconsistencies could be identified in the analysis for both the outcomes assessed and were further explored. Conclusions: Our study highlighted the potential efficacy of several agents over placebo in the improvement of mouth opening and burning sensation in OSMF patients. However, the RCTs lacked methodological soundness. Well-designed studies with a larger number of participants with a rigorous randomization process and stringent methodology are recommended to strengthen the results obtained, which may help to construct a clinical guideline for OSMF management.

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Lycopene and intralesional betamethasone injections in the management of oral submucous fibrosis

Cited by 14 publications

References 0 publications

Comparison of Triamcinolone Versus Platelet Rich Plasma Injection for Improving Trismus in Oral Submucous Fibrosis

Comparison of Triamcinolone Versus Platelet Rich Plasma Injection for Improving Trismus in Oral Submucous Fibrosis

Long‐term effectiveness of lycopene in the management of oral submucous fibrosis (OSMF): A 3‐years follow‐up study

Comparative Efficacy of Interventions for the Management of Oral Submucous Fibrosis: A Systematic Review and Network Meta-Analysis

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