Lycopene Alleviates DSS-Induced Colitis and Behavioral Disorders via Mediating Microbes-Gut–Brain Axis Balance

Zhao, Beita; Wu, Jianbin; Li, Jinghao; Bai, Yiming; Luo, Yong B.; Ji, Bing; Xia, Bing; Liu, Zhigang; Tan, Xiao Di; Lv, Jinyin; Liu, Xuebo

doi:10.1021/acs.jafc.0c00196

Cited by 90 publications

(78 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The integrity of the epithelial cells layer is essential for gut barrier function. Recently, LYC has appeared to be an essential functional nutrient for intestinal integrity [ 39 , 40 ]. In the present research, TEER in the jejunum was significantly reduced, while DAO content in the serum markedly increased after DON exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, previously, LYC protected intestinal injury induced by sulfamethoxazole [ 35 ]. Another study demonstrated that LYC treatment prevented dextran sulfate sodium-induced gut barrier damages and inflammatory responses in male rats [ 40 ]. In the current research, the increased number of MUC2+ cells in the villi and LYZ+ cells in the crypt further indicate that the LYC can protect barrier function in the small intestinal mucosa.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

et al. 2021

View full text Add to dashboard Cite

Deoxynivalenol (DON) is a threatening mycotoxin primarily present in the agricultural environment, especially in food commodities and animal forages, and exerts significant global health hazards. Lycopene (LYC) is a potent antioxidant carotenoid mainly present in tomatoes and other fruits with enormous health benefits. The present study was designed to ascertain whether LYC could protect DON-induced intestinal epithelium oxidative injury by regulating Keap1/Nrf2 signaling in the intestine of mice. A total of forty-eight mice were randomly distributed into four groups (n = 12), Control (CON), 10 mg/kg BW LYC, 3 mg/kg BW DON, and 3 mg/kg DON + 10 mg/kg LYC BW (DON + LYC). The experimental groups were treated by intragastric administration for 11 days. Our results showed that LYC significantly increased average daily feed intake (ADFI), average daily gain (ADG), and repaired intestinal injury and barrier dysfunction, as evident by increased trans-epithelial electrical resistance (TEER) and decreased diamine oxidase (DAO) activity, as well as up-regulated tight junction proteins (occludin, claudin-1) under DON exposure. Furthermore, LYC treatment stabilized the functions of intestinal epithelial cells (Lgr5, PCNA, MUC2, LYZ, and Villin) under DON exposure. Additionally, LYC alleviated DON-induced oxidative stress by reducing ROS and MDA accumulation and enhancing the activity of antioxidant enzymes (CAT, T-SOD, T-AOC, and GSH-Px), which was linked with the activation of Nrf2 signaling and degradation of Keap1 expression. Conclusively, our findings demonstrated that LYC protects intestinal epithelium from oxidative injury by modulating the Keap1/Nrf2 signaling pathway under DON exposure. These novel findings could lead to future research into the therapeutic use of LYC to protect the DON-induced harmful effects in humans and/or animals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Lycopene is a lipophilic carotenoid pigment that can diffuse into brain and has been used for the treatment of tumors and type 2 diabetes. It has shown significant antioxidant and antiapoptotic effects (Gencoglu et al, 2017;Zhao et al, 2020). Lycopene also prevents lipid peroxidation and accumulates hydrogen peroxide and superoxide in neurodegeneration studies (Park et al, 2020;Zhang et al, 2017;Zhu et al, 2020).…”

mentioning

confidence: 99%

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Erten

2021

J Food Biochem

View full text Add to dashboard Cite

show abstract

“…Different colitis models represent the human behavioral phenotype. Zhao et al (2020) found that the depression and anxiety-like behavior in dextran sulfate sodium-induced colitis model could be improved by lycopene through increasing the relative abundance of Bi dobacterium and Lactobacillus. Similarly, Jang et al (2018) inoculated Lactobacillus johnsonii to 2,4,6-trinitrobenzenesulfonic acid-induced colitis model, which improved memory impairment by restoring the disturbed gut microbiota composition.…”

Section: Introductionmentioning

confidence: 98%

Probiotic Alleviate Fluoride-Induced Memory Impairment by Reconstructing Gut Microbiota in Mice

Xin

Wang

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundFluoride which is widespread in our environment and food due to geological origin and industrial pollution has been identified as developmental neurotoxicants. Gut-brain axis provide new sight to the brain-derived injury. We hypothesized that fluoride-induced memory impairment was associated with gut dysbiosis, which could be prevented by improving the gut microbiota. MethodsMice were given fluoridated drinking water (sodium fluoride, 100 mg/L) for 70 days and administered with PBS or a probiotic strain, Lactobacillus johnsonii BS15 for 28 days prior to and throughout a 70 day exposure to sodium fluoride. ResultsResults showed that fluoride reduces the exploration ratio in Novel object recognition (NOR) test and the spontaneous exploration during the T-maze test in mice following an hour water avoidance stress (WAS), which were significantly improved by the probiotic. 16S rRNA sequencing showed a significant seperation in ileal microbiota between the fluoride-treated mice and control mice. Lactobacillus was the mainly targeting bacteria and significantly reduced in fluoride-treated mice. BS15 reconstructed the fluoride-post microbiota and increased the relative abundance of Lactobacillus. D-lactate contant and diamine oxidase (DAO) activity, two biomarkers of the gut permeability were reduced in the serum of probiotic-inocluated mice. ZO-1, an intestinal tight junction protein, which was reduced by fluoride in mRNA and protein levels were increased by the probiotic treatment. Moreover, in the hippocampus which is essential to learning and memory, the probiotic increased the down-regulated mRNA levels of myelinassociated glycoprotein (MAG) level, Bcl-xl and decreaed up-regulated mRNA levels of Bad in fluoride-treated mice. The probiotic applied in this study also increased down-regulated mRNA and protein levels of brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB), and balanced the inflammatory cytokines in mRNA and protein levels in hippocampus of fluoride-treated mice. ConclusionsThese results suggested that there may be some correlations between the fluoride-induced memory dysfunction and alteration of gut microbiota, and reconstruction of gut microbiota is a potential method to prevent the memory dysfunction.

show abstract

Lycopene Alleviates DSS-Induced Colitis and Behavioral Disorders via Mediating Microbes-Gut–Brain Axis Balance

Cited by 90 publications

References 43 publications

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Probiotic Alleviate Fluoride-Induced Memory Impairment by Reconstructing Gut Microbiota in Mice

Contact Info

Product

Resources

About