LXXXIII Further Observations on the Pathology of Menière's Disease

A Case Report of Ménière’s Disease, Emphasizing the Extent of Endolymphatic Hydrops

“…In reviewing the literature up to 1969 we found only 43 case reports, including those of H allpike (4 cases), R ollin (5 cases), L indsay (7 cases), A ltmann (8 cases), F owler (3 cases), and Scuuknecht (14 cases) [1,2]. Our case demonstrates, probably, the most severe hydrops seen and/or reported until now.…”

Menière’s Disease: Morphological Findings in Eighth Nerve and Vestibular End Organs

“…As the sensory cell population has been found to be largely well preserved (Schuknecht et al, 1962;Lindsay, 1968), the explanation of the functional lesions has been sought in biochemical and mechanical alterations leading to minute morphologi- cal changes in the sensory epithelium (Schuknecht, 1963). Pietrantoni and lurato (1960), and later also other authors, have reported such changes: loss of sensory hairs, lipofuscin inclusions in the upper parts of the cells, cuticular laminated structures, vesiculation of the sensory cell cytoplasm and occurrence of striated bodies in the subepithelial region.…”

Structure of Reissner's Membrane in the Cat Cochlea -A Light Microscopic Study

“…In the explanation of episodic attacks of Meniere's disease, Lawrence and McCabe (1959) and Schuknecht and Seifi (1962) presented the hypothesis that Reissner's membrane and the wall of the saccule were subjected to repeated rupture by over-distension of the endolymphatic system and the rupture was followed promptly by healing. The biochemical or bioelectrical alterations in the endolymph after the rupture were assumed to cause acute disturbances in sensory function, such as acute attacks of vertigo and loss of hearing.…”