Menière’s Disease: Morphological Findings in Eighth Nerve and Vestibular End Organs

Ylikoski, Jukka; Collan, Yrjö; Palva, Tauno

doi:10.1159/000275431

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…However, this hypothesis was not supported by histological studies, in which observed changes were entirely different from those observed by one of the authors (JY) in the eighth nerve of patients with perilymphatic fistula. Changes in the case presented were also different from changes in the eighth nerve of patients with such otoneurological diseases as Meniere's (Ylikoski et al, 1979), vestibular neuronitis or sudden hearing loss with vertigo (Ylikoski et al, 1981). The patient's history revealed head traumas, and plain X-rays of the skull showed an old fracture line in the right parietal bone.…”

Section: Discussionmentioning

confidence: 68%

Eighth nerve alcoholic neuropathy: A case report with light and electron microscopic findings

1981

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A 55-year-old man with symptoms of hearing loss, balance disturbance, and facial weakness was treated by translabyrinthine eighth cranial nerve trans-section. The patient also had a history and physical signs of chronic alcoholism and peripheral polyneuropathy. Results of laboratory tests revealed concomitant nutritional deficiency. Histopathological examination of the eighth nerve showed extensive degeneration of both myelinated and unmyelinated nerve fibers in both cochlear and vestibular divisions. Light and electron microscopic features of the degenerative process were compatible with previously described pathology of experimentally induced Wallerian-like degeneration. Alcoholic neuropathy as the cause of hearing loss and balance disturbance—and probably facial paresis—is suggested.

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Section: Discussionmentioning

confidence: 68%

Eighth nerve alcoholic neuropathy: A case report with light and electron microscopic findings

1981

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Vestibular Nerve in Meniere's Disease

Ylikoski¹,

Collan²,

Palva³

1980

Archives of Otolaryngology - Head and Neck Surgery

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Elektronenmikroskopische Befunde am Bindegewebe von Nervus und Ganglion vestibuli bei Morbus Menière

Galić¹,

Helms

1982

Arch Otorhinolaryngol

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Vestibular ganglia of 17 patients with Menière's disease, obtained by transtemporal or translabyrinthine neurectomy, were studied by electron microscopy. Three ganglia removed because of other disease and four ganglia of normal ears taken post mortem served as controls. The neuronal fibrous tissue of Menière cases showed without exception pathologic changes of various extent. The amount of collagen was increased, whereby different fiber diameters were observed as well as changes in the periodicity of cross banding. Signs of continuing collagen formation were found: active fibroblasts and an increased number of isolated Schwann cells without axons, showing deerhorn-like ramifications which enveloped collagen bundles. The blood vessels were frequently surrounded by multiple basal membranes and broad bands of homogenous matrix. The pericytes were either necrotic or nonexistent. The endothelial cell cytoplasma was usually not in an active state. Sometimes it seemed to be autolytic. The pinocytotic activity was strikingly diminished. These qualitative changes of the interstitial tissue might point to a local pathologic event in the region of the vestibular nerve and ganglion.

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Menière’s Disease: Morphological Findings in Eighth Nerve and Vestibular End Organs

Cited by 9 publications

References 4 publications

Eighth nerve alcoholic neuropathy: A case report with light and electron microscopic findings

Eighth nerve alcoholic neuropathy: A case report with light and electron microscopic findings

Vestibular Nerve in Meniere's Disease

Elektronenmikroskopische Befunde am Bindegewebe von Nervus und Ganglion vestibuli bei Morbus Menière

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