Luxenchalcone, a new bichalcone and other constituents from Luxemburgia octandra

Anti-inflammatory activities of flavonoids from Luxemburgia octandra flowers

“…Ochnaceae is a large tropical family including 40 genera and 600 species with the greatest concentration in tropical South America [3]. In the course of our phytochemical and pharmacological investigations of Brazilian plants, we have studied species of both Ouratea and Luxemburgia genera, in which the presence of biflavonoids was observed [4][5][6][7], along with their antitumor activities [8][9][10].In the present study we investigated the anti-inflammatory activity of the flavonoids 2cc,3cc-dihydro-ochnaflavone (1), 7-O-methylorientin (2), orientin (3), orientin 2cc-O-glucoside (4), and catechin (5) using the mouse model of ear edema.The structures of the flavonoids 2cc,3cc-dihydro-ochnaflavone (1), 7-O-methylorientin (2), orientin (3), orientin 2cc-O-glucoside (4), and catechin (5) were identified by EI-MS, 1 H NMR, 13 C NMR, and comparison of those with literature data [11,12].Flavonoids 1-5 were tested in vivo for their ability to reduce the inflammatory response in the TPA-induced ear edema in mice (1.0 mg/ear). Compounds 2 and 3 showed activity in the ear topical test, inducing an edema inhibition over 50%, which was comparable to that of indomethacin at a dose of 0.5 mg/ear (Table 1).…”

“…Ochnaceae is a large tropical family including 40 genera and 600 species with the greatest concentration in tropical South America [3]. In the course of our phytochemical and pharmacological investigations of Brazilian plants, we have studied species of both Ouratea and Luxemburgia genera, in which the presence of biflavonoids was observed [4][5][6][7], along with their antitumor activities [8][9][10].…”

A new derivative of dihydroochnaflavone isolated from Luxemburgia species (Ochnaceae) and the complete ¹H and 13C NMR chemical shifts assignments

“…Fourier transform NMR spectra were recorded on a Varian INOVA-500 model spectrometer operating at 500 MHz for 1 H and 125 MHz for 13 C. The NOE-difference experiment was recorded on a Bruker AC200 spectrometer operating at 200 MHz for 1 H. Samples were analyzed in 5 mm tubes, using CDCl 3 as solvent containing tetramethylsilane as internal standard. The natural biflavone (1) was isolated from the leaves of Luxemburgia nobilis and from L. octandra as described in the literature (Carvalho et al, 2002;Carvalho et al, 2004). Preparation of 5,5"-diacetyl-7,4',7"-trimethyl-2",3"-dihydroochnaflavone (1b)…”

“…The acetyl and the methyl derivatives were not cytotoxic to the analyzed tumour cells lines (Daniel et al, 2007;Oliveira et al, 2005). Species of Ochna, Ouratea and Luxemburgia (Ochnaceae) are great source of these natural biflavonoids (Likhitwitayawuid et al, 2001;Carvalho et al, 2002Carvalho et al, , 2004Carbonezi et al, 2007). Besides the structural determination, we have analyzed the spectral data of the natural biflavonoids and their new derivatives (Carvalho et al, 2006a,b;Carvalho et al, 2003, Carvalho andDaniel, 2005).…”

Others flavonoids from Ouratea hexasperma (Ochnaceae)

“…In previous reports we described the phytochemical study of species from the Ochnaceae including Luxemburgia [2][3][4] and Ouratea 5-8 genera. We have also isolated biisoflavonoids 9 and a flavone dimer from Ouratea hexasperma collected in Amazon cerrado.…”