Luteolytic effects of prostaglandin F2α on day 8 to 19 corpora lutea in the bitch

Romagnoli, Silvia; Camillo, Francesco; Novellini, S; Johnston, S. D.; Cela, M.

doi:10.1016/0093-691x(95)00376-j

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…In the first part of luteal phase, peripheral blood progesterone concentrations were high and similar to those found by Romagnoli et al [48] in bitches 8 to 19 days after the onset of cytological diestrus. The gradual decline of progesterone observed in dogs treated with aglepristone parallels that of controls, suggesting that this antiprogestagen triggers an anticipated, but physiological-like, luteolytic process.…”

Section: Discussionsupporting

confidence: 89%

Aglepristone (RU534) administration to non-pregnant bitches in the mid-luteal phase induces early luteal regression

et al. 2010

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Section: Discussionsupporting

confidence: 89%

Aglepristone (RU534) administration to non-pregnant bitches in the mid-luteal phase induces early luteal regression

et al. 2010

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Regulation of Corpus Luteum Function in the Domestic Dog (Canis familiaris) and Comparative Aspects of Luteal Function in the Domestic Cat (Felis catus)

Kowalewski

2016

The Life Cycle of the Corpus Luteum

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Effectiveness of a modified administration protocol for the medical treatment of canine pyometra

et al. 2014

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Pyometra is one of the most common diseases in intact bitches. The aim of this study was to evaluate the effectiveness of a modified aglepristone protocol for the medical treatment of pyometra in the bitch. Of these, 73 bitches affected by pyometra of different breeds and age (2-14 years old) were enrolled. They were randomly assigned to a control group (CTG - 26 bitches) treated with classical protocol (aglepristone at 0, 1 and 6 days - day 0 = day of the diagnosis) and a modified treated group (MTG - 47 bitches) treated with a different administration protocol (aglepristone at 0, 2, 5 and 8 days). The classical protocol with the anti-progestagen aglepristone was effective in 88.5 % (23/26) of CTG bitches while the modified protocol was effective in all (47/47) of MTG bitches. One of the 23 CTG bitches received a further administration on day 14, which resolved the pyometra, while in the three cases of CTG bitches, in which the treatment was ineffective, an ovariohysterectomy was carried out. The modified protocol showed a success rate of 100 %, compared with the classical protocol proposed in the literature, and no recurrence of the disease was recorded in the 24 months follow up. After treatment, the oestrus onset was earlier than expected (interoestrus of 128 ± 32 days). In this study, the modified treatment protocol showed high efficacy and lack of recurrence within 24 months, suggesting a complete recovery of reproductive function in the bitch, with a normal fertility.

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Luteolytic effects of prostaglandin F2α on day 8 to 19 corpora lutea in the bitch

Cited by 11 publications

References 4 publications

Aglepristone (RU534) administration to non-pregnant bitches in the mid-luteal phase induces early luteal regression

Aglepristone (RU534) administration to non-pregnant bitches in the mid-luteal phase induces early luteal regression

Regulation of Corpus Luteum Function in the Domestic Dog (Canis familiaris) and Comparative Aspects of Luteal Function in the Domestic Cat (Felis catus)

Effectiveness of a modified administration protocol for the medical treatment of canine pyometra

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