Luteolin inhibited hydrogen peroxide-induced vascular smooth muscle cells proliferation and migration by suppressing the Src and Akt signalling pathways

Abstract

These findings strongly suggested that luteolin suppresses H(2) O(2) -directed migration and proliferation in VSMCs partially due to down-regulation of the Akt and Src signalling pathways, which are important participants in the processes of migration and proliferation of VSMCs.

Salidroside Inhibits Endogenous Hydrogen Peroxide Induced Cytotoxicity of Endothelial Cells

“…Caspase, a family of cysteine proteases, is known to form integral parts of the apoptotic pathway 13) . Therefore, we investigated the protein levels and activities of caspase-3.…”

Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls

“…It has been reported that H 2 O 2 can activate Axl to facilitate VSMC migration via an Aktdependent pathway [28,29]. In addition, neointima formation in response to cuff injury was reduced in Axl knockout mice compared with Axl wild-type mice [28].…”

“…It has been previously reported that H 2 O 2 activates Axl (a redoxsensitive receptor tyrosine kinase) and its downstream Akt pathway to induce VSMC migration and proliferation [28,29]. Here, we blocked Akt with either Akt inhibitor IV that targets the ATP-binding site of a kinase upstream of Akt, or Akt inhibitor X that suppresses the kinase reactivity of Akt by inhibiting its phosphorylation.…”

Production of Phytotherapeutics in Brazil: History, Problems and Perspectives

“…3,4 Assim, a fitoterapia é um método racional e alopático, baseado em evidências científicas, empregado no tratamento médico de váriaspatologias. 5 Um levantamento bibliográfico cobrindo apenas os primeiros meses de 2012 e considerando apenas o mecanismo de ação dos princípios ativos envolvidos, mostra a eficácia das plantas medicinais no tratamento da doença de Alzheimer [6][7][8] , de doenças cardíacas [9][10][11][12] , da malária 13,14 , da leishmania 15 , da esquistossomose 16 , do câncer [17][18][19][20][21][22] , do herpes anti-inflamatório [26][27][28] , como antiúlcera 28,29 ,como antinociceptivo 30 , como antidiabético 31,32 e antidiurético 33 .…”