Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis

Kang, Kyung Pyo; Park, Sung Kwang; Kim, Duk Hoon; Sung, Mi Jeong; Jung, Yu Jin; Lee, Ae Sin; Lee, Jung Eun; Ramkumar, Kunka Mohanram; Lee, Sik; Park, Moon Hyang; Roh, Si-Gyun; Kim, Won

doi:10.1093/ndt/gfq528

Cited by 78 publications

(69 citation statements)

References 32 publications

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“…Chemotherapy leads to single and double DNA strand breaks, most often followed by cell death. Recent studies have shown the important role of apoptosis in the pathogenesis of cisplatin testicular (Arjumand et al, 2011;Kang et al, 2011) Thus, together with other herbal extracts, TT reduces apoptosis of cisplatin by decreasing the number of apoptotic cells that can be considered as the antioxidant activity or diuretic effect of TT.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice

et al. 2015

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SUMMARY:Cisplatin is an anti-cancer drug used in chemotherapy. One of the limiting side effects of cisplatin is decreasing genital gland function, azoospermia and oligospermia. Tribulus terrestris (TT) has been used as an aphrodisiac. The present study amid to investigate protective effect of TT hydroalcoholic extract against cisplatin-induced apoptosis on testis in mice. Male adult mice (n=30) were divided into control and 4 experimental groups (n=6). Control group received saline, first experimental group received cisplatin (5.5 mg/kg) and other three experimental group received cisplatin (5.5 mg/kg) and different doses of hydroalcoholic extact of TT (100, 300 and 500 mg/kg/i.p) respectively. Day after the last injection, histopathology and histomorphic analysis and also TUNEL assay on mice testis were performed. Weights of body and testis, seminiferous tubules diameter and apoptotic index were assessed. Data analysis was performed using one-way ANOVA followed by Tukeys' test. The results showed that cisplatin lead to a reduction in the weight of body and testes, and significantly increased apoptotic index compared to the control group (P<0.001), while in treated groups with TT, the weights of body and testis and seminiferous tubules diameter were significantly higher compared with cisplatin group (P<0.001), but apoptotic index did not show significant differences. The study demonstrates that extract of TT could protective effect of on cisplatin-induced apoptosis of testis and seminiferous tubules diameter that may be related to the presence of antioxidant components acting via a multitude of central and peripheral mechanisms

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice

et al. 2015

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“…All mice were individually housed under a constant temperature (24°C) and 12-h light/dark cycle, fed the AIN-76 semipurified diet for a 1-week acclimation period, and subsequently divided randomly into three groups and fed a normal diet (ND, n = 10), high-fat diet (HFD, n = 13, 20% fat and 1% cholesterol), or HFD with 0.005% (weight for weight) luteolin (LU, n = 13; Sigma-Aldrich, St. Louis, MO) for 16 weeks. The dose of luteolin was based on previous in vivo studies (9)(10)(11)(12). All experimental diets were prepared every week and stored at 24°C.…”

Section: Animalsmentioning

confidence: 99%

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

et al. 2014

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The flavonoid luteolin has various pharmacological activities. However, few studies exist on the in vivo mechanism underlying the actions of luteolin in hepatic steatosis and obesity. The aim of the current study was to elucidate the action of luteolin on obesity and its comorbidity by analyzing its transcriptional and metabolic responses, in particular the luteolin-mediated cross-talk between liver and adipose tissue in diet-induced obese mice. C57BL/6J mice were fed a normal, high-fat, and high-fat + 0.005% (weight for weight) luteolin diet for 16 weeks. In high fatfed mice, luteolin improved hepatic steatosis by suppressing hepatic lipogenesis and lipid absorption. In adipose tissue, luteolin increased PPARg protein expression to attenuate hepatic lipotoxicity, which may be linked to the improvement in circulating fatty acid (FA) levels by enhancing FA uptake genes and lipogenic genes and proteins in adipose tissue. Interestingly, luteolin also upregulated the expression of genes controlling lipolysis and the tricarboxylic acid (TCA) cycle prior to lipid droplet formation, thereby reducing adiposity. Moreover, luteolin improved hepatic insulin sensitivity by suppressing SREBP1 expression that modulates Irs2 expression through its negative feedback and gluconeogenesis. Luteolin ameliorates the deleterious effects of diet-induced obesity and its comorbidity via the interplay between liver and adipose tissue.Obesity is characterized by excessive fat accumulation and is associated with metabolic complications such as adiposity, dyslipidemia, insulin resistance, and steatohepatitis. The liver is one of the major organs responsible for metabolizing fats from the diet. Dysregulation of lipid metabolism in the liver induces abnormal accumulation of lipids and the subsequent formation of lipid droplets (LDs), known as hepatic steatosis. Hepatic steatosis is common in obese individuals and is strongly linked to insulin resistance (1,2). Adipose tissue is also a critical component of metabolic control and is an endocrine organ that secretes a number of adipokines known to mediate lipid metabolism, inflammation, and insulin sensitivity (3). Although the complex relationship between adiposity and hepatic steatosis has not been completely elucidated, dysregulation of lipid metabolism in the liver and adipose tissue may be involved in the pathogenesis of adiposity as well as its associated metabolic complications. One hypothesis for the explanation of a link between visceral adiposity and hepatic steatosis and insulin resistance is the "portal hypothesis," which proposes that a high rate of lipolysis of the visceral adipose tissue can lead to an increased delivery of free fatty acids (FFAs) to the liver via the portal vein, and that chronic exposure of the liver to elevated FFAs can promote hepatic steatosis and hepatic insulin resistance (4,5). However, it is still unclear how visceral adiposity is associated with hepatic steatosis and insulin resistance, in particular at the level of transcriptional changes that occur in ...

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“…Natural phenolics, such as hesperidin, rutin, silymarin, and genistein, have been shown to ameliorate cisplatin-mediated nephrotoxicity (Kang et al, 2011;Sahu, Kuncha, Sindhura, & Sistla, 2013). Moreover, quercetin prevented the nephrotoxic activity of cisplatin without affecting its anti-tumour activity (Sanchez-Gonzalez, Lopez-Hernandez, Perez-Barriocanal, Morales, & Lopez-Novoa, 2011).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

Yamabe

Park

Lee

et al. 2015

Journal of Functional Foods

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A B S T R A C TThe protective effects of an extract from bitter melon (Momordica charantia, Cucurbitaceae) against oxidative stress was previously reported and found that protocatechuic acid (PCA) was one of the major phenolic constituents in the extract. The renoprotective effect of PCA from bitter melon was investigated in the present study. In the LLC-PK1 cellular model, the decline in cells viabilities induced by oxidative stress, such as that induced by sodium nitroprusside, pyrogallol, and SIN-1, was significantly and dose-dependently inhibited by PCA.In the in vivo model, the cisplatin-treated rats showed increased plasma levels of creatinine, decreased creatinine clearance, and increased urine protein levels. However, these parameters related to renal dysfunction were markedly attenuated by PCA treatment. Administration of PCA resulted in remarkable improvement in the histological appearance and reduction in tubular cell damage in the cisplatin-treated rat kidneys. Moreover, the elevated levels of pro-caspase-3 induced by cisplatin in rat kidneys were down-regulated by PCA co-treatment. These results suggest that PCA has protective activity against anticancer drug-induced oxidative nephrotoxicity.

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Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis

Abstract: These results indicate that cisplatin induces acute kidney injury by regulation of p53-dependent renal tubular apoptosis and that luteolin ameliorates the cisplatin-mediated nephrotoxicity through down-regulation of p53-dependent apoptotic pathway in the kidney.

Cited by 78 publications

References 32 publications

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

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Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis

Abstract: These results indicate that cisplatin induces acute kidney injury by regulation of p53-dependent renal tubular apoptosis and that luteolin ameliorates the cisplatin-mediated nephrotoxicity through down-regulation of p53-dependent apoptotic pathway in the kidney.

Cited by 78 publications

References 32 publications

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against Cisplatin­Induced Apoptosis on Testis in Mice

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against Cisplatin­Induced Apoptosis on Testis in Mice

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

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Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice

Protective Effect of Tribulus terrestris Hydroalcoholic Extract Against CisplatinInduced Apoptosis on Testis in Mice