Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle.

Pirazzoli, P; Zappulla, F; Bernardi, Filippo; Villa, Maria Pia; Aleksandrowicz, Dov R.; Scandola, A.; Stancari, P; Cicognani, A; Cacciari, E

doi:10.1136/adc.53.3.235

Cited by 37 publications

(12 citation statements)

References 12 publications

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“…Synthetic LHRH, the hypothalam~c gonadotropinreleasing hormone, administered intranasally, has proved to be useful in treating cryptorchidism ~ (Happ et al, 1975(Happ et al, , 1978Illig et al, 1977;Pirazzoli et al, 1978). * Dedicated to Prof. Dr. H.-R. Wiedemann on the occasion of his 65th birthday ** This work was supported by the Swiss National Science Foundation (Projects nos.…”

Section: Introductionmentioning

confidence: 98%

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

1980

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Synthetic LHRH was given intranasally to 55 prepubertal boys with 67 undescended testes. After a 4-5 week period while receiving a daily dose of 1.2 mg complete testicular descent was seen in 24 testes. Follow-up over 6 to 24 months showed relapse in 4 boys who responded successfully to a second trial with LHRH. In boys with insufficient or no response to an initial trial further treatment with LHRH in 11 cases or HCG in 5 cases also was without effect. Surgical correction after unsuccessful LHRH treatment in 32 boys with 35 undescended testes showed anatomical abnormalities in 28 testes, mostly an open processus vaginalis with or without hernia. Because of its simple and painless administration and the absence of unwanted side effects, intranasal LHRH is well-suited as initial treatment of cryptorchidism, particularly in young children.

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Section: Introductionmentioning

confidence: 98%

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

1980

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“…The success rate of GnRH therapy, which has been carried out since 1975 by the nasal spray method, varies between 30 and 50% [9,11,12]. It emerges from our randomised study [12] that after completion of therapy LH values 30 min after intravenous GnRH are lower in patients without descent than in boys in whom GnRH therapy induced a descent.…”

Section: Discussionmentioning

confidence: 64%

“…In the largest of the more recent studies, the success rate for unilateral cryptorchids was 30% [6], 44% [7] and 47% [8], while the rate for bilat eral cryptorchids was approximately 40% [6][7][8], In 1975. the GnRH nasal spray method of treatment was introduced. The success rate for this therapy ranges between 30 and 50% [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Hormonal Treatment of Cryptorchidism

Hadžiselimović¹,

Girard²,

Herzog³

et al. 1982

Horm Res

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60 cryptorchid boys (39 unilateral and 21 bilateral) aged between 10 months and 14 years were treated by conservative methods. All boys received an initial therapy of 200 µg GnRH nasal spray (decapeptide) in each nostril three times daily for 4 weeks. Those who did not respond favorably to the GnRH treatment immediately received a follow-up therapy with 1,500 IU or boys over 7 years 2,000 IU of HCG per week for a total of 3 weeks. Immediately after completion of this therapy, the success rate was 80% (65/81 testes decended). 6 months afterwards 6 of the 48 testes suffered a relapse. Thus, 73% of the testicles were still descended 6 months after completion of therapy.

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“…Taking into account that epididymis differentiation is the prime mover for testicular descent (14,15), we can hypothesize that high LH stimuli are required to produce a sufficient local testosterone concentration in order to enable differentiation of epididymis and thus descent. It is interesting that Pirazzoli et al (6) showed that the brief bursts of high level LH may be more important for initiating descent than for a prolonged stimulation of low concentrations.…”

Section: Biopsy Findingsmentioning

confidence: 99%

Effect of LH-RH Treatment on Hypothalamo-Pituitary-Gonadal Axis and Leydig Cell infrastructure in Cryptorchid Boys

Hadžiselimović¹,

Girard²,

Höcht³

et al. 1980

Horm Res

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62 cryptorchid boys aged 2–6 years were selected at random either for surgical or for hormonal LH-RH treatment. As all biopsies from boys operated show typical histological and ultrastructural signs of cryptorchidism, it can be concluded that only true cryptorchid patients are included in our study. LH-RH treatment was successful in 16 (55%) of 31 boys. Median 30-min response values to LH-RH test of LH were initially normal in all boys. Those treated successfully remain normal after treatment whereas unsuccessfully treated patients have significantly lower LH 30-min response values at the end of the 4 weeks of LH-RH treatment. FSH response was not statistically different before or after treatment. This might indicate that a normal LH response is necessary for testicular descent. In the 15 boys operated after 4 weeks of unsuccessful LH-RH treatment, testes biopsies show recruitment of the Leydig cell precursors and development of juvenile Leydig cells with an increase in their content of lipoid droplets and smooth endoplasmic reticulum. No adverse effect on the number of spermatogonia could be observed after 4 weeks of LH-RH treatment.

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Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle.

Cited by 37 publications

References 12 publications

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys

Hormonal Treatment of Cryptorchidism

Effect of LH-RH Treatment on Hypothalamo-Pituitary-Gonadal Axis and Leydig Cell infrastructure in Cryptorchid Boys

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