Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model

Li, Hongtao; Huang, Caihong; Zhu, Jinzhou; Gao, Kehai; Fang, Jun; Li, Huazhuang

doi:10.12659/msm.908699

Cited by 54 publications

(32 citation statements)

References 17 publications

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“…BS supplementation could improve growth performance by enhancing nutrient absorption pathways via regulating ionic transport in the intestine of Senegalese sole, Solea senegalensis [28]. Additionally, LTN has antioxidant activity and can modulate the antioxidant balance in fish [69,70], which was confirmed in the current findings (Figure 1). However, the effect of BS and LTN as individual supplementation was not clearly obtained in rabbitfish but co-supplementation elucidated a significant improvement in growth performance and feed utilization.…”

Section: Discussionsupporting

confidence: 84%

“…In the same sense, LTN supplementation significantly increased plasma T-AOC and decreased malondialdehyde levels [69]. LTN reduced serum oxidative stress markers (TBARS and ROS) and improved glutathione levels, CAT, SOD, GSH-Px, and GST activities in plasma of ovariectomized rats [70]. Additionally, LTN supplementation improved the non-enzymatic antioxidants (total sulfhydryl and non-protein sulfhydryl groups) and reduced TBARS levels in the LTN supplemented groups [80][81][82].…”

Section: Discussionmentioning

confidence: 99%

“…Lutein could also modulate antioxidant gene expression (HO−1, NQO1) and inflammatory response genes (Nrf2 and decreases NF-kB genes) [70]. The antioxidant properties of LTN could be attributed to the presence of two hydroxyl groups in each molecule [83].…”

Section: Discussionmentioning

confidence: 99%

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Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Mansour

El-feky

El-Beltagi

et al. 2020

Animals

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A 60-day feeding trial was conducted to assess the effects of dietary supplementation with bile salts (BS), lutein (LTN), and their combination on growth, survival, carotenoid content, and antioxidant status of rabbitfish (Siganus rivulatus) larvae. Fish were fed four isonitrogenous (34.39% protein) and isoenergetic (20.57 kJ/g) diets supplemented with BS (0.15 g kg−1), LTN (0.1 g kg−1), BS+LTN (0.15 and 0.1 g kg−1, respectively), and a non-supplemented control diet. The results revealed that fish fed BS+LTN had the highest significant specific growth rate (4.37% day−1), feed efficiency (46.55%), and survival (97.78%). Lutein supplementation improved whole-body protein content, meanwhile, fish fed a BS-supplemented diet had a higher lipid content. The carotenoid deposition was significantly increased with LTN and BS+LTN in skin, muscle, and whole body compared to the control and BS treatment. All dietary supplementation of BS and LTN showed significant improvement in total antioxidant capacity, catalase, and glutathione peroxidase activities. Additionally, LTN alone or BS+LTN significantly reduced malondialdehyde levels by 5.30 and 29.91%, respectively compared to the control. BS supplementation modulated aminopeptidases activities, triglycerides, cholesterol, and increased the activity of pancreatic lipase. Therefore, it could be inferred that dietary supplementation with LTN in combination with BS could improve the growth performance, carotenoid deposition, antioxidant status, lipid digestion, and metabolism of S. rivulatus.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Mansour

El-feky

El-Beltagi

et al. 2020

Animals

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“…This study demonstrates that depletion of complex I decreases mitochondrial ATP production, increases mitochondria ROS accumulation, and increases lipid peroxidation leading to synapse dysfunction, whereas treatment with lutein reverses these effects to rescue cholinergic synapse activity [167]. Lutein increases Nrf2 and decreases NF-κB subunit p65, thus, lutein may regulate transcription of genes that control antioxidant activity and inflammation [168][169][170][171][172].…”

Section: Luteinmentioning

confidence: 84%

Anti-Apoptotic Effects of Carotenoids in Neurodegeneration

et al. 2020

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Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral ischemia, Parkinson’s, and Alzheimer’s disease. Apoptosis begins with activation of pro-death proteins Bax and Bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracellular organelles, and ultimately cell death. Approaches that block apoptotic pathways may prevent or delay neurodegenerative processes. Carotenoids are a group of pigments found in fruits, vegetables, and seaweeds that possess antioxidant properties. Over the last several decades, an increasing number of studies have demonstrated a protective role of carotenoids in neurodegenerative disease. In this review, we describe functions of commonly consumed carotenoids including lycopene, β-carotene, lutein, astaxanthin, and fucoxanthin and their roles in neurodegenerative disease models. We also discuss the underlying cellular mechanisms of carotenoid-mediated neuroprotection, including their antioxidant properties, role as signaling molecules, and as gene regulators that alleviate apoptosis-associated brain cell death.

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“…The impact of ovariectomy on the bone antioxidant system has been demonstrated [30][31][32]. Therefore, we next explored the therapeutic potential of febuxostat in OVX-induced osteoporosis models.…”

Section: Febuxostat Reduces Osteoclastic Activity and Bone Loss In Ovmentioning

confidence: 99%

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat

Ashtar

Tenshin

Teramachi

et al. 2020

Cancers

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Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of uric acid but also the formation of reactive oxygen species (ROS). ROS has been demonstrated to mediate RANKL-mediated osteoclastogenesis. In the present study, we therefore explored the role of cancer-treatment-induced ROS in RANKL-mediated osteoclastogenesis and the suppressive effects of febuxostat on ROS generation and osteoclastogenesis. RANKL dose-dependently induced ROS production in RAW264.7 preosteoclastic cells; however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. Interestingly, doxorubicin (Dox) further enhanced RANKL-induced osteoclastogenesis through upregulation of ROS production, which was mostly abolished by addition of febuxostat. Febuxostat also inhibited osteoclastogenesis enhanced in cocultures of bone marrow cells with MM cells. Importantly, febuxostat rather suppressed MM cell viability and did not compromise Dox's anti-MM activity. In addition, febuxostat was able to alleviate pathological osteoclastic activity and bone loss in ovariectomized mice. Collectively, these results suggest that excessive ROS production by aberrant RANKL overexpression and/or anticancer Cancers 2020, 12, 929 2 of 16 treatment disadvantageously impacts bone, and that febuxostat can prevent the ROS-mediated osteoclastic bone damage.

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Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model

Cited by 54 publications

References 17 publications

Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Anti-Apoptotic Effects of Carotenoids in Neurodegeneration

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat

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