Lutein

Abstract

The new dye improved intraoperative identification of the internal limiting membrane and the posterior hyaloid/vitreous base during chromovitrectomy.

Comparing the Mode of Action of Intraocular Lutein-Based Dyes With Synthetic Dyes

“…24,28 Moreover, the safety of this dye was also tested in patients that underwent pars plana vitrectomy without clinical side effects, showing, therefore, that this lutein-based dye has a safe profile to intraocular use. 25 This fact indicates that the fluidization of the membrane observed by this dye as indicated by the isotherms and vibrational spectra is not related to a possible toxicity. The disorganization of the membrane may be an important factor for the stain of the dye.…”

“…These results are consistent with the security of use these lutein-based dyes during vitreoretinal surgeries that has been already shown in preclinical and clinical studies. 25,28 The study of Phacodyne and TB interaction with anterior capsule and ERM revealed that both dyes interact with this model without altering the molecular structure of the analyzed model. Previous reports had already shown the safety and efficacy of Phacodyne during cataract surgery.…”

“…[19][20][21] In our previous publications, we have described the use of novel intraocular dyes in which Lutein is the primary component in cataract and vitreoretinal surgeries. [22][23][24][25][26][27][28] These L/Z-based dyes have shown efficacy in staining target membranes such as AC, ILM, and the vitreous, as well as an excellent safety profile. [22][23][24][25][26][27][28] The nature of the interaction of L/Z-based dyes with their target membranes is herein investigated using Langmuir monolayer models simulating the ILM, vitreous, AC, and epiretinal membrane (ERM).…”

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“…Также в литературе встречаются данные комбинированного использования контрастирующих веществ для окраски интравитреальных структур. Сочетание 0,025% БС и 1% раствора лютеина/зеаксантина -Retidyne™ Plus проявляет высокую способность к контрастированию [6,35]. Лютеин -С 40 Н 54 (ОН) 2 и его изомер зеаксантин -С 40 Н 56 О 2 являются липофильными растительными пигментами, которые придают растениям яркую окраску от желтого до оранжево-красного цвета.…”

“…Данные пигменты содержат гидроксильные группы и обладают полярностью, в связи с чем они накапливаются внутри липопротеиновых мембран. Наличие системы сопряженных двойных связей обусловливает два основных свойства лютеина: поглоще-ние сине-фиолетовой части спектра и нейтрализация окислителей и свободных радикалов [35].…”