Comparing the Mode of Action of Intraocular Lutein-Based Dyes With Synthetic Dyes

Sousa-Martins, Diogo; Caseli, Luciano; Figueiredo, Mafalda C.; Cunha, Claudia Sa E; Mota-Filipe, Hélder; Souza-Lima, Acácio A.; Belfort, Rubens; Rodrigues, Eduardo B; Maia, Maurício

doi:10.1167/iovs.14-16187

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…As ILM peeling can be a challenging technique, various vital dyes have been introduced as intraoperative tools to facilitate ILM visualisation for peeling [57]. It has been demonstrated that different dyes not only exhibit different interactions with surrogate ILM membrane models [83] but also result in different histological planes of separation of the peeled ILM from the underlying retina [84] and different immunohistochemical findings of the peeled ILM [85]. To evaluate the potential influence of vital dyes on the biomechanical properties of human ILM, Haritoglou et al [57] collected unstained ILMs peeled from human eyes undergoing vitreoretinal surgery and analysed them with AFM.…”

Section: Internal Limiting Membranementioning

confidence: 99%

Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance

Ferrara

Lugano

Sandinha

et al. 2021

Eye

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Studying the biomechanical properties of biological tissue is crucial to improve our understanding of disease pathogenesis. The biomechanical characteristics of the cornea, sclera and the optic nerve head have been well addressed with an extensive literature and an in-depth understanding of their significance whilst, in comparison, knowledge of the retina and choroid is relatively limited. Knowledge of these tissues is important not only to clarify the underlying pathogenesis of a wide variety of retinal and vitreoretinal diseases, including age-related macular degeneration, hereditary retinal dystrophies and vitreoretinal interface diseases but also to optimise the surgical handling of retinal tissues and, potentially, the design and properties of implantable retinal prostheses and subretinal therapies. Our aim with this article is to comprehensively review existing knowledge of the biomechanical properties of retina, internal limiting membrane (ILM) and the Bruch’s membrane–choroidal complex (BMCC), highlighting the potential implications for clinical and surgical practice. Prior to this we review the testing methodologies that have been used both in vitro, and those starting to be used in vivo to aid understanding of their results and significance.

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Section: Internal Limiting Membranementioning

confidence: 99%

Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance

Ferrara

Lugano

Sandinha

et al. 2021

Eye

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“…Lutein is a lipophilic carotenoid traditionally found in fruits and vegetables that is physiologically present in the macula lutea (33, 34). Recently, lutein has been proposed as a less toxic non-vital dye for retinal tissues compared to other pigments (35, 36).…”

Section: How Can Dye-related Chemotoxicity Be Reduced?mentioning

confidence: 99%

The Safest Approach to Idiopathic Epiretinal Membrane Removal

Coppola

Cicinelli

Rabiolo

et al. 2017

Ophthalmology @ Point of Care

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resulting from the proliferation of cells along the internal limiting membrane (ILM) of the macula (1, 2). The main risk factor for this condition is age. Other risk factors include trauma, ocular inflammation, and previous ocular surgery. The overall incidence in a single eye is ∼1.1% and increases to 6% in individuals aged ≥65 years (3-6). The most common symptoms associated with ERM formation are distorted vision (metamorphopsia), blurred vision, macropsia, and micropsia (7, 8). What is the traditional approach to symptomatic ErM? Traditional 20-and 23-gauge pars plana vitrectomy (PPV) with membrane peeling has been used successfully for many years to treat ERM with a postoperative morphologic and functional improvement (9-11). Nowadays, the introduction of 25-(25G) and 27-gauge (27G) PPV systems have shown superiority over traditional greater-gauge techniques, in terms of shorter surgical times, faster wound healing with less conjunctival scarring, decreased postoperative inflammation, and reduced postoperative astigmatism (12-16). Cataract extraction through phacoemulsification and subsequent intraocular lens (IOL) implantation can be performed simultaneously to PPV in presence of visually significant cataract. What are the major complications of PPV? The complication rate of PPV has been extensively reported in the current literature (17-19). Although surgical peeling represents a mainstay of ERM treatment, the frequency of peri-and postoperative complications has been globally estimated at 0.4%-0.8%. The major events are

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Macular peeling-induced retinal damage: clinical and histopathological evaluation after using different dyes

Romano

Ilardi

Ferrara

et al. 2018

Graefes Arch Clin Exp Ophthalmol

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Comparing the Mode of Action of Intraocular Lutein-Based Dyes With Synthetic Dyes

Cited by 4 publications

References 47 publications

Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance

Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance

The Safest Approach to Idiopathic Epiretinal Membrane Removal

Macular peeling-induced retinal damage: clinical and histopathological evaluation after using different dyes

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