Luteal phase support with progesterone in intrauterine insemination: a prospective randomized study

Nieto, María Inmaculada Romero; Gonzalez, Juan Lorente; Arjona-Berral, José Eduardo; Muñoz-Villanueva, María del Carmen; Castelo-Branco, Camil

doi:10.3109/09513590.2013.859242

Cited by 22 publications

(5 citation statements)

References 18 publications

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“…However, no general agreement exists regarding the efficacy of this approach. In a recent prospective randomized trial 398 infertile patients were submitted to 893 cycles of ovulation induction with gonadotropins and IUI. After IUI, the patients in the supported group received vaginal micronized progesterone capsules 200 mg/day, and those in the control group did not receive any luteal phase support.…”

Section: The Role Of Progesterone As Luteal Phase Support After Ovulamentioning

confidence: 99%

Clinical use of progesterone in infertility and assisted reproduction

Ciampaglia

Cognigni

2015

Acta Obstet Gynecol Scand

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Intramuscular or vaginal progesterone administration is critical to support the luteal phase following in-vitro fertilization and is widely employed in intrauterine insemination cycles as well. Furthermore, this hormone is usually administered in many disorders of the first trimester of pregnancy, including threatened abortion and recurrent miscarriage, but the evidence supporting its clinical efficiency is inconsistent.

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Section: The Role Of Progesterone As Luteal Phase Support After Ovulamentioning

confidence: 99%

Clinical use of progesterone in infertility and assisted reproduction

Ciampaglia

Cognigni

2015

Acta Obstet Gynecol Scand

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“…On the contrary, our findings are not in favor of luteal phase support as clinical pregnancy rates were comparable between two groups. Nieto et al reported that in infertile patients treated with mildly ovarian stimulation with recombinant gonadotropins and IUI, luteal phase support with vaginal progesterone is not associated with a higher live birth rate or clinical pregnancy rate compared with patients who did not receive any luteal phase support [ 22 ]. Similar to these findings, a recent large multicenter randomised controlled study demonstrated that in patients treated with IUI after ovarian stimulation with gonadotropins, the clinical pregnancy rate was not statistically significantly higher after luteal phase support with a vaginal progesterone gel [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Does Luteal Phase Support Effect Pregnancy Rates in Intrauterine Insemination Cycles? A Prospective Randomised Controlled Study in a Tertiary Center

Keskin

Aytaç

2020

Obstetrics and Gynecology International

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Intrauterine insemination (IUI) is a common treatment for couples with subfertility. Clomiphene citrate, gonadotropins, and letrozole are used for ovulation induction in IUI cycles. It has been well documented that luteal support with exogenous progesterone after in vitro fertilization is associated with higher pregnancy and live birth rates. Yet, luteal phase support in IUI cycles has become a debatable issue. The aim of this prospective controlled study was to assess the effect of luteal phase vaginal progesterone supplementation on β-hCG positivity and clinical pregnancy rates in women undergoing IUI. This prospective controlled randomised study was conducted at a tertiary infertility center. 87 patients with unexplained infertility or male subfertility who were treated with IUI using gonadotropins were enrolled. Patients in the study group (n = 44) received luteal phase vaginal progesterone supplementation. Patients in the control group (n = 43) did not receive any luteal phase support. There was no statistical difference between two groups in terms of β-hCG positivity and clinical pregnancy rates. Our findings do not show any beneficial effect of luteal phase support in IUI cycles stimulated with gonadotropins. Although luteal phase support in IUI cycles stimulated with gonadotropins is widely adopted, there is a lack of robust evidence.

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“…During the luteal phase LH is in low level and it is possible these amounts are not necessary for stimulation of endometrium [5]. LH secretion in infertility treatment cycle may be was in low level 10 days after the treatment with GNRH agonist and unsatisfactory to luteal stage support [6].…”

Section: Discussionmentioning

confidence: 99%

Does Progesterone Suppository to Luteal Phase Support Have Any Effect on Pregnancy Rates in the Intrauterine Insemination Cycles?

Yasaei

Eftekhar

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: Rate of infertility in overall is around 15-10%. Intra-Uterine Insemination (IUI) is one procedure for infertility treatment. Luteal phase support defect is a main factor in fail of pregnancy. Goal of this study was to evaluate the effect of luteal phase support with progesterone suppository in patients who undergoing IUI cycles. Materials & Methods:100 infertile couples who were undergoing IUI treatment included in this study. Ovulation induction was done for all patients. When IUI was done, patients were distributed into two groups. The study group (n=50) received progesterone suppository and control group (n=50) doesn't received any medicine. Then biochemical pregnancy rate, clinical pregnancy rate and abortion rate compared between two study groups.Results: There were no differences in basic characteristics between two groups. Biochemical and clinical pregnancy were parallel in the study and control groups. There were no statistically significant increases in abortion rate between the study groups (P=0.49). Conclusion:Luteal phase support by progesterone suppository does not improve the pregnancy rate of stimulated IUI cycles.

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Luteal phase support with progesterone in intrauterine insemination: a prospective randomized study

Abstract: In infertile patients treated with mildly ovarian stimulation with recombinant gonadotropins and IUI, luteal phase support with vaginal progesterone is not associated with higher livebirth rate or clinical pregnancy rate compared with patients who did not receive any luteal phase support.

Cited by 22 publications

References 18 publications

Clinical use of progesterone in infertility and assisted reproduction

Clinical use of progesterone in infertility and assisted reproduction

Does Luteal Phase Support Effect Pregnancy Rates in Intrauterine Insemination Cycles? A Prospective Randomised Controlled Study in a Tertiary Center

Does Progesterone Suppository to Luteal Phase Support Have Any Effect on Pregnancy Rates in the Intrauterine Insemination Cycles?

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