Luteal phase support for assisted reproduction cycles

Abstract

This review showed a significant effect in favour of progesterone for luteal phase support, favouring synthetic progesterone over micronized progesterone. Overall, the addition of other substances such as estrogen or hCG did not seem to improve outcomes. We also found no evidence favouring a specific route or duration of administration of progesterone. We found that hCG, or hCG plus progesterone, was associated with a higher risk of OHSS. The use of hCG should therefore be avoided. There were significant results showing a benefit from addition of GnRH agonist to progesterone for the outcomes of live birth, clinical pregnancy and ongoing pregnancy. For now, progesterone seems to be the best option as luteal phase support, with better pregnancy results when synthetic progesterone is used.

Estrogen supplementation in art (a review)

“…Гормональный профиль лютеиновой фазы цикла стимуляции суперовуляции препаратами гонадотро-пинов отличается от такового в лютеиновую фазу естественного цикла более высокой концентрацией прогестерона и эстрадиола, укорочением периода плато и выраженным снижением на 7-10-й день после введения триггера овуляции [14]. Считается, что стимуляция яичников приводит к образованию множества лютеиновых кист, неспособных обеспе-чить адекватную продукцию прогестерона.…”

“…По данным 7 исследований, частота наступления кли-нической беременности не различалась при допол-нительном назначении препаратов эстрадиола. Од-нако анализ подгрупп с разным способом введения препаратов выявил повышение частоты наступления клинической беременности в подгруппе женщин, принимавших прогестерон + трансдермальный эстрадиол по сравнению с женщинами, принимав-шими только прогестерон (OR 0,50, 95% CI 0,31-0,82) [14].…”

Has ART Finally Got a Patient-Friendly Progesterone?

“…Luteal phase support improves implantation rate and thus pregnancy rates, but the ideal method is still unclear. A large recent Cochrane review showed a significant effect in favor of progesterone for luteal phase support, favoring synthetic progesterone over micronized progesterone [1]. Overall, the addition of other substances such as estrogen or hCG did not seem to improve outcomes.…”

“…They found that hCG, or hCG plus progesterone, was associated with a higher risk of ovarian hyperstimulation syndrome (OHSS). The use of hCG should therefore be avoided [1]. There were significant results showing beneficial effects from the addition of GnRH agonist to progesterone in terms of the outcomes of live birth, clinical pregnancy, and ongoing pregnancy.…”

“…There were significant results showing beneficial effects from the addition of GnRH agonist to progesterone in terms of the outcomes of live birth, clinical pregnancy, and ongoing pregnancy. For now, progesterone seems to be the best option as luteal phase support, with better pregnancy results when synthetic progesterone is used [1].…”