Luteal phase following oocyte aspiration, in vitro fertilization, and embryo transfer in clomid/HCG-stimulated cycles

Abstract

Using basal body temperature and repeated radioimmunological plasma progesterone estimations we monitored the luteal phase in seven patients after the administration of Clomid/hCG, oocyte recovery, in vitro fertilization and embryo transfer. In six of these women, the transferred embryos did not implant, and they bled 13--16 days after oocyte recovery. Neither the basal body temperature charts nor the plasma progesterone levels provided any indication of a luteal phase defect, being indistinguishable from those obtained in a control group of healthy women during the natural cycle. In the seventh woman, transfer of an eight-cell stage embryo resulted in implantation and a pregnancy which, to date (37th week) is developing normally.

Decidual cell FKBP51–progesterone receptor binding mediates maternal stress–induced preterm birth

“…Up to 80% of PTBs occur spontaneously (5), whereas ∼20% are indicated by deteriorating maternal or fetal conditions (5). While ascending genital tract infections, abruptions, and multiple gestations account for more than half of PTBs (6), maternal stress associated with depression and posttraumatic stress disorder, and fetal stress related to abnormal placentation are strongly implicated in many idiopathic PTBs (iPTBs) (7)(8)(9). However, the underlying molecular mechanism(s) responsible for stress-associated PTB remain unclear.…”