Transfer of Human Embryos at Early Cleavage Stages

Trotnow, S.; Al‐Hasani, S.; Kniewald, T.; Becker, Howard C.; Hünlich, T.

doi:10.1007/978-3-642-68800-3_20

Cited by 11 publications

(1 citation statement)

References 14 publications

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“…Two main post‐embryo transfer protocols have been recommended: rest and mobilisation. Jones 2 advocated that patients should remain in the prone position for at least 4 hours; Schmidt 4 recommended that they be placed in complete bed rest for 18 to 24 hours following embryo transfer; full rest for 24 hours has also been advocated by Trotnow et al 5 By comparison, in a historical cohort–control study, Sharif et al 6 suggested that bed rest was of no value and that patients should be permitted to move freely.…”

Section: Introductionmentioning

confidence: 99%

Bed rest versus free mobilisation following embryo transfer: a prospective randomised study

Amarin

Obeidat

2004

BJOG

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Objective To evaluate the efficacy of two clinical methods of post-embryo transfer protocols in patients undergoing in vitro fertilisation. Design Prospective, randomised clinical trial.Setting Hospital-based clinic for reproductive medicine.Sample Women under 40 years of age who were undergoing in vitro fertilisation with GnRH pituitary downregulation and controlled ovarian hyperstimulation. Methods Patients were randomised to rest for either 1 or 24 hours after embryo transfer.Main outcome measure Clinical pregnancy per cycle rate (the percentage of cycles started that demonstrated a live fetus on ultrasound examination performed at six or seven weeks of gestation). Results The clinical pregnancy rates were 21.5% for the 1-hour and 18.2% for the 24-hour post-embryo transfer groups. The implantation rate per embryo was significantly higher in the 1-hour group (14.4%) than in the 24-hour group (9%). Conclusion One-hour and 24-hour rest post-embryo transfer result in comparable rates of clinical pregnancy.However, 24-hour rest results in reduced implantation rate per embryo.

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Section: Introductionmentioning

confidence: 99%

Bed rest versus free mobilisation following embryo transfer: a prospective randomised study

Amarin

Obeidat

2004

BJOG

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Correlation Between Human Sperm Swelling in Hypoosmotic Medium (Hypoosmotic Swelling Test) and In Vitro Fertilization

Ven

Jeyendran

Al‐Hasani

et al. 1986

Journal of Andrology

127

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Human ejaculates (n = 83) were analyzed for standard sperm parameters (concentration, motility, and morphology), as well as for the ability of the spermatozoa to react (swell) in a hypoosmotic medium (Jeyendran et al, 1984). Subsequently, the fertilizing capacity of the spermatozoa was tested by their ability to fertilize human oocytes in vitro. Although the sperm concentration was adjusted for in vitro fertilization, no adjustments were made for sperm motility and morphology. Correlation of the in vitro fertilizing capacity of the spermatozoa with the hypoosmotic swelling test (r = 0.56) was much higher than with standard sperm parameters (r varied from −0.04 to 0.25). Complete overlap was noted with standard semen parameters whether the ejaculate did or did not fertilize oocytes and ranged from very low to very high values in both cases. By contrast, all the semen samples that fertilized oocytes showed a 60% or higher reaction in the hypoosmotic swelling test, whereas the majority of the “infertile” semen samples showed less than 60% swelling. It therefore appears that, under the conditions of our studies, the hypoosmotic swelling test is a more accurate predictor of successful in vitro fertilization outcome than the conventional semen parameters. A combination of all parameters, however, is likely to be most useful. The hypoosmotic swelling test is simple and economical, and it is recommended that this test be further scrutinized for its value as an additional tool in the assessment of the in vivo fertilizing capacity of ejaculated spermatozoa.

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In-vitro-Fertilisierung und Embryotransfer

Trotnow¹

1987

Gynäkologische Endokrinologie

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Transfer of Human Embryos at Early Cleavage Stages

Cited by 11 publications

References 14 publications

Bed rest versus free mobilisation following embryo transfer: a prospective randomised study

Bed rest versus free mobilisation following embryo transfer: a prospective randomised study

Correlation Between Human Sperm Swelling in Hypoosmotic Medium (Hypoosmotic Swelling Test) and In Vitro Fertilization

In-vitro-Fertilisierung und Embryotransfer

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