Luteal function after intrauterine infusion of recombinant bovine interferon- I1 into postpartum beef cows expected to have short or normal luteal phases

Garverick, H.A.; Moser, Marianne; Keisler, D. H.; Hamilton, Stacey; Roberts, R. M.; Smith, Michael F.

doi:10.1530/jrf.0.0940319

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…Consistent with this idea, cows destined to have short-lived CL have early secretion of PGF from the uterus (Zollers et al, 1991) and an early increase in circulating metabolite of PGF that begins near the time of the first increases in circulating E2 during the first follicular wave (Southee et al, 1988;Hunter et al, 1989;Cooper et al, 1991;Hunter, 1991;Garverick et al, 1992b). In addition, intrauterine infusion of IFNT, the protein that normally causes maintenance of the CL during pregnancy in ruminants, can prevent short luteal phases (Garverick et al, 1992a). At least part of the action of IFNT is a reduction in uterine secretion of PGF.…”

Section: Period I: Short Luteal Phase and Early CL Regression -Day 5-7mentioning

confidence: 99%

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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In ruminants, there are specific times during the estrous cycle or pregnancy when the corpus luteum (CL) may undergo regression. This review has attempted to summarize the physiological and cellular mechanisms involved in CL regression or maintenance during four distinct periods. The first period is near day 7 when animals that are ovulating after a period of low circulating progesterone (P4), such as first pubertal ovulation or first postpartum ovulation, are at risk of having a premature increase in Prostaglandin F2α (PGF) secreted from the uterus resulting in early CL regression and a short estrous cycle. The second period is when normal luteolysis occurs at day 18-25 of the cycle or when the CL is rescued by interferon-tau secreted by the elongating embryo. The uterine mechanisms that determine the timing of this luteolysis or the prevention of luteolysis have been generally defined. Induction and activation of endometrial E2 receptors result in induction of endometrial oxytocin receptors that can now be activated by normal pulses of oxytocin. Of particular importance is the observation that the primary mechanisms are only activated through local (ipsilateral) and not a systemic route due to transfer of PGF from the uterine vein to the ovarian artery. In addition at the CL level, studies are providing definition to the cellular and molecular mechanisms that are activated in response to uterine PGF pulses or pregnancy. The third period that is discussed occurs in the second month of pregnancy (day 28-60) when undefined mechanisms result in CL maintenance of an ipsilateral CL but regression of a contralateral (opposite side from pregnancy) CL. The final period that is discussed is regression of the CL just prior to parturition. Although, cortisol from the fetus appears to be the primary initiator of luteolysis, PGF seems to be the final signal that causes regression of the CL. Thus, in all four periods, regression of the CL is likely to be caused by the direct actions of PGF that is secreted from the uterus. The uterine mechanisms that result in secretion of PGF seem to be normally inhibited during the early luteal phase, making short luteal phases not a normal event, and are altered during early pregnancy (day 18-25) resulting in prevention of luteolysis. During much of pregnancy, the mechanisms that cause PGF secretion from the uterus in response to oxytocin are intact but luteolysis does not normally occur, perhaps due to lack of efficient utero-ovarian transfer of PGF.

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Section: Period I: Short Luteal Phase and Early CL Regression -Day 5-7mentioning

confidence: 99%

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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“…[24,25]. In sheep, exogenous interferons have been shown to augment conception rates following natural mating [27,28] and to suppress the luteolytic effects of estradiol [29]; and in cattle, exogenous interferons extend the short luteal phase that occurs following the first postpartum ovulation [30].…”

Section: Introductionmentioning

confidence: 99%

Premature Luteal Regression Induced by Equine Chorionic Gonadotropin and Estrogen is Suppressed by Administration of Exogenous Interferon in Red Deer (Cervus Elaphus)1

Bainbridge

Deakin

Jabbour

1998

Biology of Reproduction

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Superovulation of red deer hinds with eCG causes premature luteal regression by inducing follicular hypersecretion of estrogen that activates the luteolytic mechanism. Six groups of hinds (n = 8 per group) were treated with progesterone-impregnated intravaginal controlled internal drug-releasing (CIDR) devices for 14 days to synchronize estrus (CIDR device withdrawal = Day 0). Group 1 served as controls; group 2 received an i.m. injection of 1200 IU eCG at -72 h; group 3 received similar eCG treatment as well as i.m. injections of 0.25 mg estradiol benzoate (EDB) at 72, 84, 96, and 108 h; group 4 received twice-daily i.m. injections of 4 mg recombinant bovine interferon-alpha(I)1 (IFN) from Days 2 to 7; group 5 received IFN and eCG as above; group 6 received IFN, eCG, and EDB. Ovarian response was determined by laparoscopy on Days 14 and 15. Progesterone profiles were determined from thrice-weekly plasma samples from Days -14 to 28. Both the incidence of visible signs of luteal regression and the variation in the time of termination of the luteal phase (plasma progesterone < 1 ng/ml) were greater in eCG+EDB-treated hinds than in control, IFN-, IFN+eCG-, and IFN+eCG+EDB-treated hinds (p < 0.05). The ovulation rate in the eCG+EDB-treated hinds was less than that in the eCG-, IFN+eCG-, and IFN+eCG+EDB-treated hinds (p < 0.05). These results suggest that treatment with interferon, the putative embryonic pregnancy recognition signal, suppresses premature luteal regression induced by hypersecretion of estrogen following treatment with eCG.

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“…The more readily available recombinant interferons have been shown to suppress endometrial PGF2a production in vitro in sheep (Salamonsen et al 1988) and cattle (Barros et al 1990). Furthermore, a recent study in post-partum cows showed that intra¬ uterine infusion of recombinant bovine interferon-rxi 1, starting 4-5 days prior to the time of expected premat¬ ure luteolysis, significantly extended luteal lifespan (Garverick et al 1992). In view of the data presented in the current study it is tempting to speculate that the mechanism involves suppression of endometrial oxytocin receptor concentrations.…”

Section: Autoradiographymentioning

confidence: 48%

“…In view of the data presented in the current study it is tempting to speculate that the mechanism involves suppression of endometrial oxytocin receptor concentrations. However, in this and previous studies in this laboratory where ovula¬ tion has been induced in early post-partum ewes, pre¬ mature luteolysis is characterized by very transient progesterone secretion around day 4 of the cycle com¬ pared with the short luteal phase of post-partum cows which varies from 8 to 11 days (Zollers et al 1991 A; Garverick et al 1992). Whether conceptus interferons could similarly rescue the corpus luteum destined to regress prematurely in post-partum ewes is perhaps unlikely but remains to be established.…”

Section: Autoradiographymentioning

confidence: 64%

Oxytocin receptor concentrations, inositol phosphate turnover and prostaglandin release by endometrium from ewes induced to ovulate during the early post-partum period

Wallace¹,

Thompson²,

Aitken³

et al. 1993

Journal of Endocrinology

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Induction of ovulation early post partum in sheep is associated with a high incidence (30-40%) of premature luteolysis. The present study was designed to characterize oxytocin receptor levels, oxytocin-stimulated inositol phosphate (IP) turnover (second messenger) and oxytocin-stimulated prostaglandin F2 alpha (PGF2 alpha) release in the endometrium of post-partum ewes induced to ovulate 21 days after parturition and expected to exhibit a range of corpus luteal functions subsequently. Ovulation was induced on day 21 post partum using a controlled internal drug release device and pregnant mare serum gonadotrophin, and uterine tissues were collected on days 5, 10 or 15 of the cycle (n = 4/day). A further 12 ewes whose interval from previous parturition exceeded 150 days were similarly treated and acted as controls. Measurement of daily peripheral progesterone concentrations revealed that while all control ewes exhibited normal luteal function, abnormal luteal function was evident in two, two and one post-partum ewes studied on days 5, 10 and 15 of the cycle respectively. Oxytocin receptor binding was detected (by receptor-binding assay and in-vitro autoradiography) in the endometrium and myometrium of post-partum ewes at all three stages of the oestrous cycle but only at day 15 in control ewes. To determine IP turnover, 100 mg caruncular endometrium was incubated in duplicate for 2.5 h with 10 microCi [3H]inositol and treated with 0 or 2 mumol oxytocin/l for 30 min, then [3H]inositol mono-, bis- and trisphosphates were quantified.(ABSTRACT TRUNCATED AT 250 WORDS)

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Luteal function after intrauterine infusion of recombinant bovine interferon- I1 into postpartum beef cows expected to have short or normal luteal phases

Cited by 16 publications

References 25 publications

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Premature Luteal Regression Induced by Equine Chorionic Gonadotropin and Estrogen is Suppressed by Administration of Exogenous Interferon in Red Deer (Cervus Elaphus)1

Oxytocin receptor concentrations, inositol phosphate turnover and prostaglandin release by endometrium from ewes induced to ovulate during the early post-partum period

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