Lupus Vasculitis: An Overview

Leone, Patrizia; Prete, Marcella; Malerba, Eleonora; Bray, Antonella; Susca, Nicola; Ingravallo, Giuseppe; Racanelli, Vito

doi:10.3390/biomedicines9111626

Cited by 40 publications

(59 citation statements)

References 144 publications

(185 reference statements)

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“…Patients with systemic lupus erythematosus (SLE) were intentionally excluded in this study since they are more likely to develop both inflammatory and thrombotic (due to antiphospholipid syndrome) vasculopathies 35 . Therefore, evaluation of SLE vasculopathy is needed in further studies.…”

Section: Discussionmentioning

confidence: 99%

Angiographic characteristics of vasculopathy in patients with idiopathic inflammatory myopathies and systemic sclerosis

Yeo

Park

Lee

et al. 2022

Sci Rep

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To describe the peripheral angiographic features of vasculopathy in idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc) in comparison to polyarteritis nodosa (PAN). Angiograms of 47 extremities (24 upper and 23 lower) of 11 patients with IIM (n = 5) and SSc (n = 6), and 12 patients with PAN who presented with critical limb ischemia were retrospectively analyzed with regards to the presence of stenosis, occlusion, aneurysms and delayed distal flow, and degree of neovascularization. Diffuse narrowing was more frequent (66.1 vs. 38.0%, p = 0.001), whereas multifocal stenosis (6.5% vs. 26.8%, p = 0.002), abrupt occlusion (11.3% vs. 29.6%, p = 0.010) and aneurysm formation (1.6% vs. 11.3%, p = 0.037) were less frequent in IIM/SSc than PAN. In distal arteries, tapered occlusion (95.5% vs. 76.0%, p = ns) and delayed flow (77.3% vs. 48.0%, p = 0.039) were more common in IIM/SSc than PAN. After 1 year, auto- or surgical amputation tended to be more frequent in IIM/SSc than PAN (36.4% vs. 16.7%, p = ns). In conclusion, diffuse narrowing, tapered occlusion and delayed distal flow on conventional angiograms tend to be more frequent in IIM/SSc than PAN. Further studies are needed to verify these findings in a larger prospective cohort.

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Section: Discussionmentioning

confidence: 99%

Angiographic characteristics of vasculopathy in patients with idiopathic inflammatory myopathies and systemic sclerosis

Yeo

Park

Lee

et al. 2022

Sci Rep

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“…LV normally appears during active disease and can be associated with APS. 26,27 The skin is affected in 90% of the cases. Less frequent is the involvement of the nervous system gastrointestinal tract, lungs, kidney, and heart.…”

Section: Discussionmentioning

confidence: 99%

Sudden Death in a Young Male Patient: When Lupus and Cardiovascular Disease Intersect

Silva¹,

Aragao²,

Bonisson³

et al. 2022

MRAJ

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Herein we present the case of a 27-year-old male patient who was recently diagnosed with Systemic Lupus Erythematosus (SLE) associated with nephritis with atypical findings on kidney biopsy and premature cardiovascular disease despite scarce traditional risk factors and negative laboratory findings for antiphospholipid syndrome. A literature review on the epidemiology and pathogenesis of coronary disease in SLE was conducted. The patient was admitted for pulse therapy after refractory disease on outpatient care but evolved with ventricular fibrillation secondary to acute thrombosis in the proximal segment of the anterior left descending artery, with no evidence of atherosclerotic disease. Laboratory findings were also negative for antiphospholipid syndrome both upon diagnosis and after the coronary event. He underwent manual thrombus aspiration and angioplasty with a drug-eluting stent, successfully weaning off mechanical ventilation and vasopressors at the intensive care unit and showing no neurological deficits or left ventricular function impairment. Kidney biopsy later resulted positive for immunoglobulin A nephropathy. The patient was discharged asymptomatic on guideline-directed therapy for coronary disease, warfarin associated with clopidogrel, anti-hypertensive drugs and a combination of immunosuppressants, remaining well on three-month follow-up. SLE is a chronic inflammatory disease that has increasingly been recognized as a major cardiovascular risk factor due to a variety of mechanisms involving accelerated atherosclerosis and thrombosis. As patients survive the first years of disease onset from infection and disease-specific complications, cardiovascular outcomes become a great concern. However, early events such as in this case are possible, especially in the context of flaring disease. We emphasize the importance of an interdisciplinary approach to such patients for better outcomes.

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“…As a complication of SLE, choroidopathy usually presents with single or multiple areas of serous detachment of the retinal pigment epithelium and neurosensory retina or retinal pigment epitheliopathy. The emerging choroidal effusion leading to anterior displacement of the lens–iris diaphragm may cause secondary angle-closure glaucoma with subsequent intraocular hypertension [ 51 ]. In 2019, an article was published that confirmed that the choroid in SLE patients appears to be thinner, particularly in the subset of patients with nephritis and taking anticoagulants, suggesting more advanced systemic vascular disease.…”

Section: Ophthalmic Manifestations Of Slementioning

confidence: 99%

Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature

Luboń

Kotyla

et al. 2022

IJMS

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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. Up to one-third of patients suffering from SLE have various ocular manifestations. The ocular findings may represent the initial manifestation of the systemic disease and may lead to severe ocular complications, and even loss of vision. Ocular manifestations are often associated with degree of systemic inflammation, but also can precede the occurrence of systemic symptoms. Early diagnosis and adequate management of patients with SLE are crucial and require cooperation between various specialists. Proper preparation of ophthalmologists can help to differentiate between complication of SLE and other ocular disorders. New therapies for SLE are promising for potential benefits, however, ocular side effects are still unknown.

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Lupus Vasculitis: An Overview

Cited by 40 publications

References 144 publications

Angiographic characteristics of vasculopathy in patients with idiopathic inflammatory myopathies and systemic sclerosis

Angiographic characteristics of vasculopathy in patients with idiopathic inflammatory myopathies and systemic sclerosis

Sudden Death in a Young Male Patient: When Lupus and Cardiovascular Disease Intersect

Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature

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