Lupus nephritis and non-Hodgkin lymphoma simultaneously diagnosed in a patient on methimazole

Lionaki, Sophia; Vlachopanos, Georgios; Georgalis, Argyrios; Ziakas, Panayiotis D.; Gakiopoulou, Hariklia; Petra, Cristian; Boletis, John

doi:10.1177/0961203312467668

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Frequencies of visits for neoplasm were also elevated in patients during the pre-SLE period. Patients with SLE had elevated risk for developing cancer late in the diseases course [32] and a concordance development of the SLE and cancer has also been reported [33]. Moreover, the ICD-9-CM codes for neoplasm (140–239) contain not only malignant tumors but also benign tumors.…”

Section: Discussionmentioning

confidence: 89%

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

et al. 2014

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ObjectiveTo investigate the records of ambulatory medical care from patients predating the diagnosis of systemic lupus erythematosus (SLE) using nationwide, population-based claims data.MethodsThe frequencies and costs of ambulatory medical care utilization in 337 newly-diagnosed SLE cases between 2004 and 2010, identified from Taiwan's National Health Insurance Research Database, were compared with 1,348 controls who were frequency matched for sex, age, and the catastrophic illness certificate application year of the cases.ResultsPatients with SLE had a median frequency of ambulatory medical care utilization compared with controls one year prior to the index date (22 vs. 2, P<0.001). The differences were significant throughout all eight annual periods. Similarly, the inflation-adjusted costs of ambulatory medical care utilization in patients with SLE increased annually over the study period, from a median of US$18 eight years prior to the index date to US$680 one year prior to the index date. Diseases of the respiratory system (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes 460–519), digestive system (ICD-9-CM codes 520–579), musculoskeletal system and connective tissue (ICD-9-CM codes 710–739, excluding 710.0), and skin and subcutaneous tissue (ICD-9-CM codes 680–709) were the top four common causes of visits in the 0.5 to 2 year period preceding the index date and percentages of SLE patients suffered from these disorders increased progressively over the study period. Only 56.4% of the patients with SLE had consulted a rheumatologist and most of the serology tests were done within one year predating the index date.ConclusionsIncreased frequencies and costs of ambulatory care utilization among Taiwanese patients with SLE occurred several years predating their definitive SLE diagnosis. When multisystemic disorders are presented in young female patients, the possibility of SLE should be considered and screened with tools such as the antinuclear antibody test.

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Section: Discussionmentioning

confidence: 89%

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

et al. 2014

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“…The of crescentic induction of glomerulopathy associated with ANCA (Anti-Neutrophil Cytoplasmic Antibody), especially by anti-myeloperoxidase antibodies (MPO-ANCA) [22], has been proposed as one of the possible pathogenic mechanisms of kidney injury due to methimazole use [23]. Furthermore, there is a case of a patient who developed lupus nephritis due to systemic lupus erythematosus presumably induced by methimazole use [24]. The exact mechanism that mediates the injury of methimazole in MCD are unknown; one possibility is a direct damage in the podocyte and in the base membrane [21].…”

Section: Discussionmentioning

confidence: 99%

Minimal change disease associated with Graves’ disease and methimazole use

Rodríguez-Gutiérrez

Cabezas

2022

Rev. Colomb. Nefrol.

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Introduction. Graves' disease causes kidney injury through multiple mechanisms, including the treatment for this condition. Nephrotic syndrome due to minimal change disease (MCD) is an unusual form of such kidney injury; the association between methimazole use and MCD is also rare. Case presentation. 36-year-old woman with a history of Graves' disease in use of methimazole for several months, who presented with edematous syndrome due to nephrotic syndrome associated with a KDIGO stage 3 acute kidney injury. Thionamide-induced hypothyroidism and the need of thyroid hormone replacement therapy was evidenced at the time of consultation. Based on a renal biopsy, the patient was diagnosed with MCD. Her condition worsened as she experienced oliguria and hypervolemia, and renal replacement therapy with hemodialysis was temporarily required. Methimazole administration was suspended, and treatment consisting of prednisolone administration and levothyroxine supplementation was started, achieving hemodialysis suspension, gradual improvement of proteinuria until remission and full and maintained recovery of renal clearance. Radioiodine therapy was implemented as definitive treatment for Graves' disease, obtaining a successful outcome. Conclusions. Graves' disease and methimazole use are possible causes of minimal change disease. Systemic corticosteroid therapy is a possible management. However, further basic, clinical and epidemiological research on this subject is required.

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“…Systematic lupus erythematosus (SLE) is an autoimmune disease characterized by multisystem organ involvement, heterogeneity of clinical features, and a variety of degrees of severity, of which lupus nephritis is constituted with one of the most common causes of morbidity and mortality. However, previous studies showed that SLE could be secondary to infections, hematological malignancies, solid tumors, drugs, and so on (2), with renal involvement (3)(4)(5)(6)(7).…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature indicated that lupus-like syndrome could be caused by infections, hematological malignancies, solid tumors, and so forth ( 2 ). However, renal involvement presented as lupus nephritis is rare ( 3 – 7 ). In this research, we describe a rare case of mixed proliferative and membranous lupus nephritis, secondary to mantle cell lymphoma, and partially recovered after chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Case Report: A Rare Case of Lupus Nephritis Associated With Mantle Cell Lymphoma

Bao

Tan

et al. 2021

Front. Med.

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In this research, we described a very rare case of secondary lupus nephritis associated with B-cell lymphoma. An 84-year-old man was hospitalized at our institute for lower extremity edema persisting for over 2 months. He was diagnosed with systemic lupus erythematosus based on clinical and laboratory criteria, which showed impaired renal function and nephrotic syndrome with predominant hematuria. Renal biopsy showed IV+V lupus nephritis with highly infiltrated lymphoid cells in the kidney. Secondary lupus nephritis was suspected based on the possible pathogenesis of glomerular injury due to mantle cell lymphoma. Low-dose dexamethasone, rituximab, and lenalidomide were immediately started on the patient, and his renal function was improved after the first cycle of chemotherapy.

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Lupus nephritis and non-Hodgkin lymphoma simultaneously diagnosed in a patient on methimazole

Cited by 10 publications

References 22 publications

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

Minimal change disease associated with Graves’ disease and methimazole use

Case Report: A Rare Case of Lupus Nephritis Associated With Mantle Cell Lymphoma

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