Case Report: A Rare Case of Lupus Nephritis Associated With Mantle Cell Lymphoma

Abstract

In this research, we described a very rare case of secondary lupus nephritis associated with B-cell lymphoma. An 84-year-old man was hospitalized at our institute for lower extremity edema persisting for over 2 months. He was diagnosed with systemic lupus erythematosus based on clinical and laboratory criteria, which showed impaired renal function and nephrotic syndrome with predominant hematuria. Renal biopsy showed IV+V lupus nephritis with highly infiltrated lymphoid cells in the kidney. Secondary lupus nephritis was suspected based on the possible pathogenesis of glomerular injury due to mantle cell lymphoma. Low-dose dexamethasone, rituximab, and lenalidomide were immediately started on the patient, and his renal function was improved after the first cycle of chemotherapy.

Diagnosis and treatment of secondary nephrotic syndrome with rash as the first symptom: a case report

“…MCL can not only complicate NS but also coexist with a series of other renal diseases, such as membranoproliferative glomerulonephritis (MPGN), acute kidney injury (AKI), and lupus nephritis (LN) [ 12 , 13 ]. Therefore, it is also necessary to screen for MCL or other hematologic disorders when making the corresponding renal disease diagnosis, and the mechanisms regarding the complications of these renal diseases remain to be explored.…”