Lupus erythematosus panniculitis

Alizade, Narges; Rafiei, Rana; Mesbah, Alireza; Sara, Naji Rad

doi:10.7241/ourd.20174.121

Cited by 3 publications

(7 citation statements)

References 8 publications

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“…El LEC crónico se divide a su vez, por orden de frecuencia, en lupus eritematoso discoide (LED) en el 80% de los casos, LE timidus, LE neonatal y LE profundo, reportado solo en el 1%-3% de los casos. 3 La posibilidad de presentar LES sincrónico con LEP se reporta sólo en el 2% al 5% de los pacientes. 3,4 Kaposi describió por primera vez en 1883 la presencia de nódulos en pacientes con LES.…”

Section: Discussionunclassified

“…3 La posibilidad de presentar LES sincrónico con LEP se reporta sólo en el 2% al 5% de los pacientes. 3,4 Kaposi describió por primera vez en 1883 la presencia de nódulos en pacientes con LES. El término LEP fue propuesto posteriormente por Irgang en 1940, al describir el caso de una paciente con placas infiltradas en espalda asociado a una lesión discoide en cara.…”

Section: Discussionunclassified

“…Se considera que es una dermatosis primaria o secundaria a enfermedades autoinmunes como LES, esclerodermia y síndrome de Sjögren hasta en el 50% de los casos. 3,4 El abordaje de los pacientes con probable LEP debe ser extenso, con laboratorios séricos, perfil reumatológico y biopsia incisional profunda del sitio de la lesión.…”

Section: Introductionunclassified

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Lupus Eritematoso Cutáneo Profundo en un hombre adolescente. Informe de Caso

Barrera-Ochoa¹,

Cano-Aguilar²,

Colmenero-Mercado³

et al. 2022

Acta Pediatr Mex

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INTRODUCCIÓN: El lupus eritematoso (LE) es una enfermedad autoinmune poco frecuente en el sexo masculino, que presenta manifestaciones clínicas múltiples relacionadas al pronóstico de la enfermedad. La etiología es desconocida, sin embargo, se relaciona a la exposición de radiación ultravioleta y alteración en la función linfocítica. El lupus eritematoso profundo (LEP) es una variante clínica de LE cutáneo que se presenta entre el 1% al 3% de los pacientes y únicamente el 10% de los casos reportados en la literatura pertenecen al sexo masculino. Hasta el 50% de los pacientes con LEP presentan progresión a lupus eritematoso sistémico (LES) durante su evolución.PRESENTACIÓN DEL CASO: Adolescente 16 años, previamente sano, que presentó una placa eritematosas, induradas y asintomáticas en mejilla izquierda de evolución crónica. Se realizó biopsia incisional con diagnóstico de LEP. El resto del abordaje para descartar lupus eritematoso sistémico resultó negativo. El paciente recibió tratamiento con corticosteroide tópico por 4 semanas en esquema de reducción así como fotoprotección estricta con mejoría del eritema y disminución del área indurada. Actualmente el paciente continúa en seguimiento con atención a signos y síntomas sugerentes de lupus eritematoso sistémico.CONCLUSIÓN: El LEP es una dermatosis multifactorial poco frecuente en el sexo masculino, por lo que la literatura actual podría no ser representativa en este sexo. Es necesario realizar un abordaje amplio al momento del diagnóstico con pruebas de laboratorio séricas y reumatológicas. Es de suma importancia ser capaces de identificar de manera temprana signos y síntomas que sugieran progresión a LES o linfoma.

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Section: Discussionunclassified

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Lupus Eritematoso Cutáneo Profundo en un hombre adolescente. Informe de Caso

Barrera-Ochoa¹,

Cano-Aguilar²,

Colmenero-Mercado³

et al. 2022

Acta Pediatr Mex

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“…Plasma cells, lymphoid follicles, and eosinophils may also be present [ 4 ]. Presence of mucin deposition along with epidermal changes such as degeneration indicates coexistence of DLE and LP, which is seen in as many as 70% cases [ 5 ]. There were no epidermal changes in our case, hence, our diagnosis remains isolated for LP.…”

Section: Discussionmentioning

confidence: 99%

“…SLE accompanying LP is reported in as few as 2%-5% cases; 15% are able to progress to SLE and 50% have evidence of SLE. Hence, LP can be taken as an initial presenting manifestation of SLE [ 5 ]. Zhao et al have reported only 10 cases of SLE that initially presented with LP from the internet-based medical literature search [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Lupus Profundus: A Case Report from Pakistan

Siddiqui

Bhatti

Ashfaq

2018

Cureus

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Lupus erythematosus (LE) is termed as an autoimmune chronic condition which involves a spectrum of symptoms. It is a part of the connective tissue diseases. Its cutaneous form is termed as cutaneous lupus erythematosus (CLE). Prevalence of CLE is about 70 cases per 100,000 persons. The least common variety of CLE is lupus profundus (LP)—only 5% of cases. Lupus profundus, although rare, must be kept in the differential diagnoses of ulcerated lesions. It may present as a localized entity or in association with systemic lupus erythematosus (SLE) or it may lead to SLE later in life. Early diagnosis based on histopathology and aggressive treatment is essential to prevent significant physical morbidity and progression to systemic involvement. We report a case of biopsy-proven lupus profundus in a 40-year-old female who presented with high-grade fever and multiple ulcerated lesions. The lesions were appreciated on the left thigh, right gluteus, and left arm. They had an erythematous base and edematous necrotizing centers with purulent discharge. She had a history of oral ulcers, joint pain, photosensitivity, dyspnea, peptic ulcer disease, and signs of depression. Her autoimmune assays were unremarkable. We treated her with antibiotics, oral hydroxychloroquine, and oral corticosteroid. Potassium permanganate wash and methylprednisolone aceponate were applied locally on the lesions. Ulcerated LP is a rare cause of ulcerated/indurated, painful subcutaneous plaques. It may present as a localized entity or in association with SLE or it may lead to SLE later in life.

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Lupus Erythematosus Profundus with Multiple Overlying Cutaneous Ulcerations: A Rare Case

Sutedja,

Widjaya,

Dharmadji

et al. 2023

CCID

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Lupus erythematosus profundus (LEP) is a rare subset of chronic cutaneous lupus erythematosus (CCLE), with a reported incidence of 1–3% in all LE cases. The most common cutaneous clinical presentation includes indurated plaques or subcutaneous nodules with an overlying normal skin. The clinical findings range from skin redness to features of CCLE, such as scaling, follicular plugging, and atrophy. Ulceration is rare and occurs in 28% of all LEP cases. We present a case report of LEP with multiple cutaneous ulcers on the right cheek and scalp accompanied by cicatricial alopecia. No other systemic manifestations were noted. Histopathological examination revealed periadipocyte, perivascular, and perivascular infiltration of lymphocytes, eosinophils, and plasma cells, supporting the diagnosis of LEP. The topical treatments given to the patient were sunscreen, 2% mupirocin cream, and wound dressing with dialkyl carbamoyl chloride (DACC). The patient was also treated systemically with oral corticosteroids and hydroxychloroquine. Clinical improvements were observed in the 3rd month of follow-up, and ulcer healing resulted in atrophic scars and fading erythematous macules. LEP is seldom associated with systemic or discoid lupus erythematosus. This occurs twice as frequently as a distinct entity does. Diagnosis accuracy plays an important role in determining the appropriate wound care, topical, and systemic treatments for LEP patients with multiple overlying cutaneous ulcerations.

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Lupus erythematosus panniculitis

Cited by 3 publications

References 8 publications

Lupus Eritematoso Cutáneo Profundo en un hombre adolescente. Informe de Caso

Lupus Eritematoso Cutáneo Profundo en un hombre adolescente. Informe de Caso

Lupus Profundus: A Case Report from Pakistan

Lupus Erythematosus Profundus with Multiple Overlying Cutaneous Ulcerations: A Rare Case

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