Lupeol inhibits the proliferation and migration of MDA-MB-231 breast cancer cells <i>via</i> a novel crosstalk mechanism between autophagy and the EMT

Zhang, Xin; Gao, Zhan-Wang; Chen, Kehan; Zhuo, Qing-Yuan; Chen, Meixian; Wang, Jiansong; Lai, Xiaoping; Wang, Lingli

doi:10.1039/d2fo00483f

Cited by 13 publications

(2 citation statements)

References 31 publications

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“… 66 At ethical endpoints, the mice were sacrificed and the tumors were harvested. Similar regimens were followed for combinatorial studies, with Lupeol (20 mg/kg/2 days) (intraperitoneal) 67 and/or 5FU (10 mg/kg/2 days) 68 (intraperitoneal), as well as mouse HGF. In addition, initial cytotoxicity studies with the above-mentioned treatment regimens were conducted in non-tumor-bearing BALB/c mice.…”

Section: Methodsmentioning

confidence: 99%

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer

Mitra,

Saha,

Das

et al. 2023

iScience

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Section: Methodsmentioning

confidence: 99%

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer

Mitra,

Saha,

Das

et al. 2023

iScience

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“…Signi cantly, our prior investigation also revealed the capacity of lupeol to stimulate autophagy, thereby ultimately mitigating the progression of triple negative breast cancer, its proliferation, and metastasis. Considering the signi cant interconnection observed between autophagy, exosomes, and tumor development, it is plausible to suggest that lupeol may exert a pivotal in uence on the process of exosome secretion and autophagy [19] . Consequently, this phenomenon could potentially be harnessed as a viable therapeutic approach for the treatment of hepatic cancer.…”

Section: Introductionmentioning

confidence: 99%

A Novel Role for Lupeol in Hepatocellular Carcinoma Treatment via Promoting Autophagy to Suppress Exosome Secretion

CHEN,

ZHANG,

LIU

et al. 2024

Preprint

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Malignant hepatocellular carcinomas (HCC) are among the most lethal malignancies globally, posing a significant challenge for treatment due to the scarcity of viable therapeutic interventions. This study aims to explore the potential anti-tumor properties of lupeol, a naturally occurring triterpenoid found in diverse vegetables, fruits, and herbs. Initially, it was discovered that lupeol demonstrates significant in vitro anti-proliferative and anti-metastatic properties. Furthermore, the presence of lupeol resulted in a decrease in exosome levels, while the restoration of exosome levels subsequently led to the resµMption of cell proliferation and migration capabilities. In addition, the investigation of intrinsic mechanisms demonstrated that lupeol may inhibit exosome levels by inducing autophagy, while investigation of intrinsic mechanisms has demonstrated that lupeol may inhibit exosome levels by inducing autophagy. The current investigation elucidated the anti- HCC mechanism of lupeol, thereby proposing its potential as an alternative therapeutic approach or dietary supplement for HCC. Additionally, this study offers novel perspectives on the importance of autophagy and exosome involvement in HCC progression.

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Unveiling the anticancer, antimicrobial, antioxidative properties, and UPLC-ESI-QTOF-MS/ GC–MS metabolite profile of the lipophilic extract of siam weed (Chromolaena odorata)

Zhu

et al. 2023

Arabian Journal of Chemistry

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Lupeol inhibits the proliferation and migration of MDA-MB-231 breast cancer cells via a novel crosstalk mechanism between autophagy and the EMT

Abstract: Lupeol could inhibit TNBC cells by inducing autophagy, and additionally suppressing the tumor migration and invasion.

Cited by 13 publications

References 31 publications

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer

A Novel Role for Lupeol in Hepatocellular Carcinoma Treatment via Promoting Autophagy to Suppress Exosome Secretion

Unveiling the anticancer, antimicrobial, antioxidative properties, and UPLC-ESI-QTOF-MS/ GC–MS metabolite profile of the lipophilic extract of siam weed (Chromolaena odorata)

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