“…5,6 Although MTX has a wide dosage administration range, low-dose MTX has side effects, while high-dose MTX even poses life-threatening side effects. [7][8][9][10] In addition, the total body clearance (40-400 mL min −1 ) of MTX is highly variable due to the metabolism differences between individuals. Measuring MTX in patient blood samples is believed to be important for safe medication and personalized medicine.…”
As a folate antagonist, Methotrexate (MTX) has been widely used in clinic with good effect on various tumors and inflammatory diseases. While, the optimum dosage and total body clearance of...
“…5,6 Although MTX has a wide dosage administration range, low-dose MTX has side effects, while high-dose MTX even poses life-threatening side effects. [7][8][9][10] In addition, the total body clearance (40-400 mL min −1 ) of MTX is highly variable due to the metabolism differences between individuals. Measuring MTX in patient blood samples is believed to be important for safe medication and personalized medicine.…”
As a folate antagonist, Methotrexate (MTX) has been widely used in clinic with good effect on various tumors and inflammatory diseases. While, the optimum dosage and total body clearance of...
“…We thank Dr Gohar for his recent letter to Clinical and Experimental Dermatology , and his interest in our case report and discussion . Pulmonary fibrosis arising in association with methotrexate (MTX) therapy was first reported in the 1970s in the context of cancer chemotherapy with very high doses (up to 3.5 g/m 2 ).…”
Presenting their research work at an international conference can be the highlight of an academic career for a researcher, and an invitation to attend a conference as a
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.