a This population was reported by PREPIC2. All participants also received anticoagulation. b We downgraded certainty by one step due to some imprecision and risk of bias concerns (low numbers of events and open-label study design). c Major bleeding was defined as bleeding that contributed to death; occurred at a critical site (e.g. intracranial, intraspinal, epidural, or lung haemorrhage); led to transfusion of 2 or more units of red cells, platelets, or fresh frozen plasma; or was associated with a decrease in the haemoglobin level of more than 2 grams per decilitre within any 24 hour period a er injury (Schulman 2005).
Summary of findings 2. Retrievable vena caval filters with anticoagulation compared to anticoagulation for prevention of PE following multiple traumatic injuriesDoes the use of vena caval filters prevent PE in people who have sustained multiple trauma? Patient or population: participants who sustained multiple traumatic injuries a Settings: hospital Intervention: retrievable VCF (with anticoagulation and IPC) b Comparison: no VCF (with anticoagulation and IPC) Anticipated absolute effects* (95% CI) Outcomes Risk with no VCF, with an-Risk with VCF, with anticoag-Relative risk (95% CI) No of Participants (RCTs) Certainty of the evidence (GRADE) Comments Cochrane Library Trusted evidence. Informed decisions. Better health.