Lungenfunktionsuntersuchungen nach einseitiger Lungenhomotransplantation an emphysematösen Hunden

Abstract

Experimental emphysema was induced by multiple intratracheal instillation of Papain in a dose of 2 mg/kg body weight in 4 bastard dogs. Development of emphysema was objectivated by pulmonary function tests. Increase of static lung compliance, decrease of lung elastance, and increase of air-way resistance were observed. In addition arterial pO2 decreased while pCO2 remained constant. Following single lung homotransplantation there was an increase of respiratory rate and minute ventilation, the transpulmonary pressure rose in the first postoperative days, static lung compliance was diminished. Four weeks after transplantation typical functional changes of emphysema could be demonstrated concerning the slope and appearance of the compliance loops. Arterial pO2 however remained within the normal range. This functional behaviour does not support the concept of a ventialtion perfusion imbalance after lung transplantation in emphysema patients. Respiratory insufficiency therefore is probably caused by an alveolar type of rejection.

Allotransplantation of the lung in dogs with experimental lung damage

“…1), with an increase of hysteresis of the lung measured from pressure volume diagrams, an increase in functional residual capacity (FRC), and a slight increase (in some animals, a marked increase) in airway resistance when forced ventilation was performed by a respirator. We have previously described these changes in detail [5][6][7].…”

“…To achieve this, we produced experimental emphysema in dogs by intratracheal instillation of the proteolytic enzyme papain. We have described the technique and the methods of studying pulmonary function previously [5][6][7]. We observed the development of emphysema by pulmonary function tests which were done at weekly intervals.…”

“…However, to date, the results of lung transplantation in patients with emphysema have been poor, with the exception of one 53-year-old man with massive emphysema who survived 6 months. Some authors [1, Presented at the XXVIIth Congress of the Socirt6 Internationale de Chirurgie, Kyoto, Japan, September [3][4][5][6][7][8]1977.…”

Bronchospirometrische Ergebnisse nach einseitiger Lungenhomotransplantation an Hunden mit experimentell erzeugtem Lungenemphysem

“…Die Gründe für diese ungünstigen Ergebnisse sind vielfältig. Sie reichen von einfachen mechanischen bis zu immunologischen Mechanismen (4). Ein großes Problem ist nach Meinung einiger Autoren eine postoperativ auftretende Ventilations-Perfusionsstörung, die zu einer globalen respiratorischen Insuffizienz führt.…”