Lungenbeteiligung bei hämatologischen Systemerkrankungen

Abstract

Pulmonary diseases can occur across the entire disease spectrum of malignant hematologic systemic diseases. Although infectious processes of the lungs are common in these immunosuppressed patient collectives, noninfectious causes account for up to half of the pulmonary manifestations found in hematologic malignancies. Besides the frequent infections including opportunistic pathogens, a broad differential diagnosis including drug-induced lung injury by cytostatic substances, cytokines, and innovative immunotherapeutic agents, rarer transfusion of blood products and intrathoracic manifestations of the hematologic malignancy itself, have to be kept in mind. Finally, vascular complications can also lead to pulmonary reactions. Early and consistent diagnostics and treatment of the bronchopulmonary, intrathoracic and vascular complications within the framwework of hematologic systemic diseases can be essential for the patient's prognosis.

1

“…Based on the dynamic management and analysis of medical documents, the prevalence of clinically significant pulmonary complications was confirmed. Their frequency was 82.5 % that is higher than in other studies [7,10]. Most of these complications manifested in the acute phase of chemotherapy protocol, which corresponds to literature data [10,12,13].…”

“…According to previous studies, pulmonary complications are common in pediatric hematological malignancies [7]. Lung involvement in children with acute leukemia is typical during the acute phase of chemotherapy [5,6].…”

Repeated pulmonary nodules as the primary symptom of familial hemophagocytic lymphohistiocytosis in adults: a case report and review

“… 1 However, few clinical cases associated with hemophagocytic lymphohistiocytosis (HLH) have been reported. 3 As a type of HLH, familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive inherited hematological disorder. 4 Patients with FHL show extra-hematological involvement that commonly involves the nervous and hepatobiliary system, and rarely involves the respiratory system (except for co-infections).…”