Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report

Pavlík, I.; Jahn, P.; Morávková, Monika; Mátlová, L.; Treml, F.; Čížek, Alois; Nesnalová, E; Dvorska-Bartosova, L.; Halouzka, R.

doi:10.17221/1987-vetmed

Cited by 22 publications

(40 citation statements)

References 23 publications

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“…Until the middle of 2010, the most commonly identified member of the MAC in horses was M. a. avium (Aupperle et al, 2008;Pavlik et al, 2008;Ryhner et al, 2009), whereas M. a. hominissuis was the most common isolate from tuberculous lesions in pigs (Pavlik et al, 2005;Shitaye et al, 2006). Recently, M. a. hominissuis infection in this two sibling Fjord horses was described in the Czech Republic (Kriz et al, 2010a).…”

Section: Discussionmentioning

confidence: 99%

“…As reviewed by Pavlik et al (2004), after the successful control of bovine tuberculosis in cattle and other animal species in Central European countries, Mycobacterium avium complex (MAC) members have been the most commonly found causal agents of mycobacterial infection in horses. As it stands, mycobacterial infections caused by MAC are occasionally diagnosed in horses in Europe (Aupperle et al, 2008;Pavlik et al, 2008;Ryhner et al, 2009;Kriz et al, 2010a). However, infections of horses caused by M. bovis are still reported from countries in which bovine tuberculosis in cattle has not yet been eradicated (Keck et al, 2010).…”

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confidence: 99%

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Mycobacterium avium subsp. hominissuis infection in two sibling Fjord horses diagnosed using quantitative real time PCR: a case report

Blahutkova¹,

Fictum²,

Škorič³

et al. 2011

Vet. Med. - Czech

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This report describes new possibilities for intravital and post mortem diagnosis of avian mycobacteriosis in horses using the quantitative real time PCR (qPCR) method. Using this method, Mycobacterium avium subsp. hominissuis was diagnosed in two sibling Fjord horses. In the first horse, M. a. hominissuis was detected by qPCR in numbers of 2.89 × 10 5 and 1.47 × 10 4 cells per 1 g of intestinal content and mesenteric lymph nodes, respectively; in the second horse, faeces and mesenteric lymph node samples showed numbers of 6.31 × 10 5 and 3.36 × 10 6 cells per 1 g of tissue, respectively. Another aim of this study was to comprehensively describe clinical and pathological findings in both animals.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Mycobacterium avium subsp. hominissuis infection in two sibling Fjord horses diagnosed using quantitative real time PCR: a case report

Blahutkova¹,

Fictum²,

Škorič³

et al. 2011

Vet. Med. - Czech

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“…avium and hominissuis (Pavlik et al . ) ( Fig ). In contrast to cattle, only experimental infections of M. avium ssp .…”

Section: Introductionmentioning

confidence: 93%

“…Mycobacterial infections are rare in horses (Pavlik et al . ), probably because the horse appears to possess a strong innate resistance to mycobacterial infections (Mair ; Pavlik et al . ).…”

Section: Introductionmentioning

confidence: 99%

Disseminated alimentary mycobacteriosis in the horse: a retrospective study of nine cases

Mönki

Hewetson

Hahn

et al. 2015

Equine Veterinary Education

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Summary This paper summarises the clinical findings of 9 cases of disseminated alimentary mycobacteriosis in horses presented at a Finnish referral equine hospital 2009–2014. Four of 9 horses were Standardbreds and 8/9 horses were male. The median age was 2 years, ranging from 6 months to 15 years. The duration of clinical signs before admission ranged from 2 weeks to 6 months. All horses demonstrated deterioration of the clinical signs after a protracted period of the disease and were finally subjected to euthanasia after poor response to multiple medical therapies. The most common complaints on admission were weight loss and diarrhoea (9/9), pyrexia (7/9), ventral oedema (7/9), lethargy (7/9) and inappetance (6/9). The most common clinicopathological abnormalities were hypoalbuminaemia and hyperfibrinogenaemia, which were present in all horses. Rectal biopsy specimens were examined from 5/9 horses and specimens were stained with Ziehl‐Nielsen (ZN). At rectal biopsy, mild multifocal neutrophilic or mild granulomatous proctitis was recognised in all 5 horses, but the ZN stain for mycobacteria was positive in only one biopsy. A liver biopsy was taken from one horse in which hepatomegaly was observed clinically and revealed marked granulomatous hepatitis with the presence of mycobacteria. The rectal biopsy from this horse was ZN negative. At post mortem examination, chronic, multifocal to coalescing granulomatous typhlocolitis and lymphadenitis were found in all horses with the small intestine less frequently involved. At histopathological examination of post mortem samples, a ZN stain was performed and intracellular acid‐fast bacilli were identified in macrophages and multinucleated giant cells in the large intestine, liver and lymph nodes in 9/9 horses and in the small intestine in 5/9 horses. Mycobacterium avium ssp. hominissuis was isolated in 5/9 horses from post mortem samples.

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“…Nevertheless, none of them were tested for infection (Kul et al, 2005). M. a. avium can also infect different species of mammals including humans Thorel et al, 2001;Ocepek et al, 2003;Cho et al, 2006;Shitaye et al, 2006;Moravkova et al, 2007;Pavlik et al, 2008).…”

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confidence: 99%

Mycobacterium avium subsp. avium in domestic pigeons (Columba livia f. domestica) diagnosed by direct conventional multiplex PCR: a case report

Kříž¹,

Slaná²,

Mrlík³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:We report three pigeons euthanized in a small household breeding facility, where there was suspicion of an avian tuberculosis outbreak. For rapid identification of Mycobacterium avium subsp. avium direct conventional multiplex PCR was used. Nodular lesions were found on the livers of all three birds, the intestine of one bird and the kidney and ovaries of another. The liver samples and a further 18 tissue samples were examined. Acid-fast rods were detected in all the tissue samples after Ziehl-Neelsen staining. Isolation and diagnosis of M. a. avium (serotype 1 containing IS901) from 17 tissue samples was confirmed using conventional multiplex PCR.

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Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report

Cited by 22 publications

References 23 publications

Mycobacterium avium subsp. hominissuis infection in two sibling Fjord horses diagnosed using quantitative real time PCR: a case report

Mycobacterium avium subsp. hominissuis infection in two sibling Fjord horses diagnosed using quantitative real time PCR: a case report

Disseminated alimentary mycobacteriosis in the horse: a retrospective study of nine cases

Mycobacterium avium subsp. avium in domestic pigeons (Columba livia f. domestica) diagnosed by direct conventional multiplex PCR: a case report

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