Lung stem cells

Kotton, Darrell N.; Fine, Alan

doi:10.1007/s00441-007-0479-2

Cited by 79 publications

(70 citation statements)

References 236 publications

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“…However, lungs contain progenitor cells and stem cells that are critical to lung tissue regeneration and repair [26,27]. Further studies are needed to determine how lung stem cells and other lung cell types respond to refill fluid and if chronic exposure to inhaled refill fluid affects lung health.…”

Section: Discussionmentioning

confidence: 99%

Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models

Bahl¹,

Lin²,

Xu³

et al. 2012

Reproductive Toxicology

340

365

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a b s t r a c tElectronic cigarettes (EC) and refill fluids are distributed with little information on their pre-and postnatal health effects. This study compares the cytotoxicity of EC refill fluids using embryonic and adult cells and examines the chemical characteristics of refill fluids using HPLC. Refill solutions were tested on human embryonic stem cells (hESC), mouse neural stem cells (mNSC), and human pulmonary fibroblasts (hPF) using the MTT assay, and NOAELs and IC 50 s were determined from dose-response curves. Spectral analysis was performed when products of the same flavor had different MTT outcomes. hESC and mNSC were generally more sensitive to refill solutions than hPF. All products from one company were cytotoxic to hESC and mNSC, but non-cytotoxic to hPF. Cytotoxicity was not due to nicotine, but was correlated with the number and concentration of chemicals used to flavor fluids. Additional studies are needed to fully assess the prenatal effect of refill fluids.

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Section: Discussionmentioning

confidence: 99%

Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models

Bahl¹,

Lin²,

Xu³

et al. 2012

Reproductive Toxicology

340

365

View full text Add to dashboard Cite

show abstract

“…The recent progress in research shows the evidence that the stem cells may exhibit their trans-differentiation in organs including lung. The well established archetype of lung adult stem cells explored the knowledge about transient amplification of cell progeny [2]. Especially the lung is consisting of persistent tissue incorporated with infrequently proliferating epithelial, interstitial and endothelial cell populations [2].…”

Section: Introductionmentioning

confidence: 99%

“…The well established archetype of lung adult stem cells explored the knowledge about transient amplification of cell progeny [2]. Especially the lung is consisting of persistent tissue incorporated with infrequently proliferating epithelial, interstitial and endothelial cell populations [2]. There is a scarcity of classical stem cell hierarchy for these kinds of essential tissues [2].…”

Section: Introductionmentioning

confidence: 99%

“…Especially the lung is consisting of persistent tissue incorporated with infrequently proliferating epithelial, interstitial and endothelial cell populations [2]. There is a scarcity of classical stem cell hierarchy for these kinds of essential tissues [2]. It is known that some differentiated mature epithelial cells and denovo epithelial progenitors may also exhibit their role in repair mechanism [2].…”

Section: Introductionmentioning

confidence: 99%

“…There is a scarcity of classical stem cell hierarchy for these kinds of essential tissues [2]. It is known that some differentiated mature epithelial cells and denovo epithelial progenitors may also exhibit their role in repair mechanism [2]. The therapeutic target is the biggest problem to cure acute lung injury (ALI) at the molecular level, in this regards the researchers finding some important evidence to bring down the normal mechanism by treating with the stem cell therapeutics.…”

Section: Introductionmentioning

confidence: 99%

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Stem Cells and Lung Injury

2017

JSRT

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The patho-physiological pattern of acute lung injury is a complex phenomenon. The recent progress in research shows the evidence that the stem cells may exhibit their trans-differentiation in organs including lung. This development in stem cell biology related to acute lung injury has opened a lot of challenges and appreciation related to the development of therapeutic strategies for this disease. It is found that mesenchymal stem cell helps in strengthening the immune response to lessen the effect of this disease. Stem cells present within the organ found to play important role in regenerating the cells. Hence these cells have innumerable strength in curbing this disease. However very little is known about the actual molecular mechanism played by the stem cells and studies are need to be addressed before the knowing the therapeutic potential of stem cells for ALI.

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Controlling Differentiation of Stem Cells for Developing Personalized Organ‐on‐Chip Platforms

Geraili

Jafari

Hassani

et al. 2017

Adv Healthcare Materials

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Organ‐on‐chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self‐renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue‐ and organ‐on‐chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart, liver, lung, tumor, and vascular), with an emphasis on the critical role of stem cells in the synthesis of complex tissues. This study further recaps the design, fabrication, high‐throughput performance, and improved functionality of stem‐cell‐based OOCs, technical challenges, obstacles against implementing their potential applications, and future perspectives related to different experimental platforms.

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Lung stem cells

Cited by 79 publications

References 236 publications

Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models

Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models

Stem Cells and Lung Injury

Controlling Differentiation of Stem Cells for Developing Personalized Organ‐on‐Chip Platforms

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