Lung injury study by 15 days inhalation exposure of titanium dioxide nanoparticles in rats

Lee, Kyuhong; Yang, Yong; Kwon, Soonjin; Lee, Jinsu; Choi, Seungjin; Seo, Heung-Shick; Kang, Min-Sung; Lee, Byeongchan; Kim, Soo-Nam; Yang, Hyeo-Sun; Han, Young-Ah; Ryu, Hee-Jin; Heo, Jeong‐Doo; Cho, Kyu-Hyuk; Song, Chuyi; Cho, Kyu-Heok

doi:10.1016/j.toxlet.2009.06.647

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been a limited number of relevant studies done with inhalation and the results have been contradictory. Some studies have reported pulmonary neutrophilia after exposure to TiO 2 nanoparticles whereas others have not [ 15 - 20 ]. Comparison of these ENM is difficult due to different or insufficient methods of particle characterisation.…”

Section: Discussionmentioning

confidence: 99%

Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model

et al. 2010

View full text Add to dashboard Cite

BackgroundNanotechnology and engineered nanomaterials (ENM) are here to stay. Recent evidence suggests that exposure to environmental particulate matter exacerbates symptoms of asthma. In the present study we investigated the modulatory effects of titanium dioxide particle exposure in an experimental allergic asthma.MethodsNonallergic (healthy) and ovalbumin-sensitized (asthmatic) mice were exposed via inhalation to two different sizes of titanium dioxide particles, nanosized (nTiO2) and fine (fTiO2), for 2 hours a day, three days a week, for four weeks at a concentration of 10 mg/m3. Different endpoints were analysed to evaluate the immunological status of the mice.ResultsHealthy mice elicited pulmonary neutrophilia accompanied by significantly increased chemokine CXCL5 expression when exposed to nTiO2. Surprisingly, allergic pulmonary inflammation was dramatically suppressed in asthmatic mice which were exposed to nTiO2 or fTiO2 particles - i.e. the levels of leucocytes, cytokines, chemokines and antibodies characteristic to allergic asthma were substantially decreased.ConclusionsOur results suggest that repeated airway exposure to TiO2 particles modulates the airway inflammation depending on the immunological status of the exposed mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Alveolar macrophages usually contain enzymatic and non-enzymatic antioxidants that scavenge ROS; however, these are insufficient to prevent oxidative stress and pulmonary damages [35,36]. TNPs have been found to cause pulmonary damage and inflammation [37,38]. Acute exposure to TNP rods and dots for 24 h caused pulmonary and cardiac edema, lung and systemic inflammation, and platelet aggregation [39,40].…”

Section: Respiratory Systemmentioning

confidence: 99%